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Ultrasonic Vocalizations and Stress ...

Stafford, Nathaniel P.

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Ultrasonic Vocalizations and Stress Resilience: Behavioral and Neurobiological Correlates.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Ultrasonic Vocalizations and Stress Resilience: Behavioral and Neurobiological Correlates./
Author:	Stafford, Nathaniel P.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	128 p.
Notes:	Source: Dissertations Abstracts International, Volume: 79-12, Section: B.
Contained By:	Dissertations Abstracts International79-12B.
Subject:	Neurosciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10814325
ISBN:	9780438035423

Ultrasonic Vocalizations and Stress Resilience: Behavioral and Neurobiological Correlates.
Stafford, Nathaniel P.

Ultrasonic Vocalizations and Stress Resilience: Behavioral and Neurobiological Correlates. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 128 p.

Source: Dissertations Abstracts International, Volume: 79-12, Section: B.

Thesis (Ph.D.)--University of New Hampshire, 2018.

This item must not be sold to any third party vendors.

When we are exposed to a traumatic or stressful life event, some individuals may develop symptoms of anxiety or depression while others may appear unaffected. In humans and nonhuman organisms, the ability to cope plays a large role in how an organism responds to a stressor, and this coping may be influenced by innate mechanisms. We have identified the use of ultrasonic vocalizations during intermittent swim stress (ISS) to forecast innate behavioral differences in stress reactivity. Vocalizing rats are resilient as they exhibit less cognitive impairment, motivational changes, and fewer anxiety-like behaviors typically observed post-ISS. Resilience should be associated with an active, stress buffering coping strategy during ISS, whereas non-vocalizing should exhibit more passive behaviors. These active or passive behaviors are driven by a corticolimbic serotonergic circuit originating in the dorsal raphe nucleus. Active coping is associated with reduced dorsal raphe serotonin activity, which leads to reduced post-stress impairment. We hypothesized vocalizing rats would engage in active coping responses, display fewer anxiety-like behaviors, and exhibit decreased serotonergic activation in the dorsal raphe nucleus compared with non-vocalizing rats. We found vocalizing rats exhibited reduced post-stress social anxiety, but engaged in passive coping during stress. Vocalizing rats further exhibited increased serotonergic activity in stress-responsive subregions of the dorsal raphe nucleus compared to non-vocalizing and unstressed controls. These data are the first to verify the coping strategy and associated serotonergic activity of vocalizing rats as a novel model of stress resilience.

ISBN: 9780438035423Subjects--Topical Terms:

588700
Neurosciences.

Ultrasonic Vocalizations and Stress Resilience: Behavioral and Neurobiological Correlates.
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100 1 $a Stafford, Nathaniel P. $3 3436578
245 1 0 $a Ultrasonic Vocalizations and Stress Resilience: Behavioral and Neurobiological Correlates.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2018
300 $a 128 p.
500 $a Source: Dissertations Abstracts International, Volume: 79-12, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Drugan, Robert C.
502 $a Thesis (Ph.D.)--University of New Hampshire, 2018.
506 $a This item must not be sold to any third party vendors.
520 $a When we are exposed to a traumatic or stressful life event, some individuals may develop symptoms of anxiety or depression while others may appear unaffected. In humans and nonhuman organisms, the ability to cope plays a large role in how an organism responds to a stressor, and this coping may be influenced by innate mechanisms. We have identified the use of ultrasonic vocalizations during intermittent swim stress (ISS) to forecast innate behavioral differences in stress reactivity. Vocalizing rats are resilient as they exhibit less cognitive impairment, motivational changes, and fewer anxiety-like behaviors typically observed post-ISS. Resilience should be associated with an active, stress buffering coping strategy during ISS, whereas non-vocalizing should exhibit more passive behaviors. These active or passive behaviors are driven by a corticolimbic serotonergic circuit originating in the dorsal raphe nucleus. Active coping is associated with reduced dorsal raphe serotonin activity, which leads to reduced post-stress impairment. We hypothesized vocalizing rats would engage in active coping responses, display fewer anxiety-like behaviors, and exhibit decreased serotonergic activation in the dorsal raphe nucleus compared with non-vocalizing rats. We found vocalizing rats exhibited reduced post-stress social anxiety, but engaged in passive coping during stress. Vocalizing rats further exhibited increased serotonergic activity in stress-responsive subregions of the dorsal raphe nucleus compared to non-vocalizing and unstressed controls. These data are the first to verify the coping strategy and associated serotonergic activity of vocalizing rats as a novel model of stress resilience.
590 $a School code: 0141.
650 4 $a Neurosciences. $3 588700
650 4 $a Psychobiology. $3 555678
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710 2 $a University of New Hampshire. $b Psychology. $3 2103486
773 0 $t Dissertations Abstracts International $g 79-12B.
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791 $a Ph.D.
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793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10814325