東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Cancer Nano-Theranostics with High C...

Ray, Sayoni.

Linked to FindBook

Google Book

Amazon

博客來

Cancer Nano-Theranostics with High Contrast MRI.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Cancer Nano-Theranostics with High Contrast MRI./
Author:	Ray, Sayoni.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
Description:	214 p.
Notes:	Source: Dissertations Abstracts International, Volume: 80-10, Section: B.
Contained By:	Dissertations Abstracts International80-10B.
Subject:	Chemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13810037
ISBN:	9781392017890

Cancer Nano-Theranostics with High Contrast MRI.
Ray, Sayoni.

Cancer Nano-Theranostics with High Contrast MRI. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 214 p.

Source: Dissertations Abstracts International, Volume: 80-10, Section: B.

Thesis (Ph.D.)--University of California, Los Angeles, 2019.

This item must not be sold to any third party vendors.

One of the holy grails in cancer therapy is to simultaneously image and deliver drugs to the tumor site. The first part of the thesis has developed new ideas in cancer theranostics and the second part is about the development of a novel contrast agent for risk-free imaging of the tumor. In the first project of the thesis, I have discussed the development of a liposome-based cargo delivery strategy that can simultaneously monitor alternating magnetic field-induced drug release by observing the change in MRI relaxation parameter R1, and the location and condition of liposomal site (such as tumor) from MRI parameter R2. However, the loading of a contrast agent in liposomes generally results in poor contrast and suffers from various artifacts in in vivo experiments, compared to the use of free contrast agent. Thus, the second project of my work in this part demonstrates the effective filtering of artifacts and contrast enhancement to obtain high quality sensitive imaging of the tumor site in a mouse model using paramagnetic liposomes, a novel pulsing sequence in active-feedback MRI, and robust data analysis. The second part of my work is about using a self-replicating viral-RNA molecule derived from Nodamura, an insect virus, to express and amplify ferritin, leading to increased iron content of the cells in the form of ferrihydrite that acts as a novel contrast agent. In summary, my thesis is about the development of cancer theranostics and a novel contrast agent. In the last part of the thesis, I have reviewed the current development of rapidly growing state of the art magnetic resonance cancer theranostics for commonly used polymer-based nanovehicles.

ISBN: 9781392017890Subjects--Topical Terms:

516420
Chemistry.

Cancer Nano-Theranostics with High Contrast MRI.
LDR:02774nmm a2200337 4500 001 2209441
005 20191104073437.5
008 201008s2019 ||||||||||||||||| ||eng d
020 $a 9781392017890
035 $a (MiAaPQ)AAI13810037
035 $a (MiAaPQ)ucla:17579
035 $a AAI13810037
040 $a MiAaPQ $c MiAaPQ
100 1 $a Ray, Sayoni. $3 3436534
245 1 0 $a Cancer Nano-Theranostics with High Contrast MRI.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2019
300 $a 214 p.
500 $a Source: Dissertations Abstracts International, Volume: 80-10, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Gelbart, William M.;Knobler, Charles M.
502 $a Thesis (Ph.D.)--University of California, Los Angeles, 2019.
506 $a This item must not be sold to any third party vendors.
520 $a One of the holy grails in cancer therapy is to simultaneously image and deliver drugs to the tumor site. The first part of the thesis has developed new ideas in cancer theranostics and the second part is about the development of a novel contrast agent for risk-free imaging of the tumor. In the first project of the thesis, I have discussed the development of a liposome-based cargo delivery strategy that can simultaneously monitor alternating magnetic field-induced drug release by observing the change in MRI relaxation parameter R1, and the location and condition of liposomal site (such as tumor) from MRI parameter R2. However, the loading of a contrast agent in liposomes generally results in poor contrast and suffers from various artifacts in in vivo experiments, compared to the use of free contrast agent. Thus, the second project of my work in this part demonstrates the effective filtering of artifacts and contrast enhancement to obtain high quality sensitive imaging of the tumor site in a mouse model using paramagnetic liposomes, a novel pulsing sequence in active-feedback MRI, and robust data analysis. The second part of my work is about using a self-replicating viral-RNA molecule derived from Nodamura, an insect virus, to express and amplify ferritin, leading to increased iron content of the cells in the form of ferrihydrite that acts as a novel contrast agent. In summary, my thesis is about the development of cancer theranostics and a novel contrast agent. In the last part of the thesis, I have reviewed the current development of rapidly growing state of the art magnetic resonance cancer theranostics for commonly used polymer-based nanovehicles.
590 $a School code: 0031.
650 4 $a Chemistry. $3 516420
650 4 $a Nanotechnology. $3 526235
650 4 $a Biophysics. $3 518360
690 $a 0485
690 $a 0652
690 $a 0786
710 2 $a University of California, Los Angeles. $b Chemistry. $3 2104984
773 0 $t Dissertations Abstracts International $g 80-10B.
790 $a 0031
791 $a Ph.D.
792 $a 2019
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13810037