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Drug Delivery Systems and Combinatio...

Kydd, Janel Lauren.

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Drug Delivery Systems and Combination Therapy for Oncomedicine.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Drug Delivery Systems and Combination Therapy for Oncomedicine./
Author:	Kydd, Janel Lauren.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
Description:	192 p.
Notes:	Source: Dissertations Abstracts International, Volume: 80-12, Section: B.
Contained By:	Dissertations Abstracts International80-12B.
Subject:	Bioengineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13883587
ISBN:	9781392265482

Drug Delivery Systems and Combination Therapy for Oncomedicine.
Kydd, Janel Lauren.

Drug Delivery Systems and Combination Therapy for Oncomedicine. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 192 p.

Source: Dissertations Abstracts International, Volume: 80-12, Section: B.

Thesis (Ph.D.)--University of Massachusetts Lowell, 2019.

This item must not be sold to any third party vendors.

Cancer treatment offers one of the biggest challenges to the healthcare in the United States and across the world. Even if the primary tumor gets cured, the complexity of this diseases often causes relapse affecting the standard of living of the patients. The relapse is often the difficult to treat using the same treatment. This is attributed to the resistance offered by tumor towards a single agent. Using combination treatment/ therapies can overcome this this drug resistance. In this dissertation, a combination treatment was used incorporating photodynamic therapy and chemotherapy. The limitations of these therapies include poor drug solubility and bioavailability resulting in reduced therapeutic efficiency. The objective of this research was to improve the bioavailability of the drugs used in chemotherapy and PDT by integrating nanotechnology to deliver the payload selectively to the tumor cells. The drug delivery systems (DDS) used in both above-mentioned therapies were polyethylene glycol coated (PEGylated) polymer-based (poly lactic-co-glycolic acid (PLGA)) nanoparticles.This study aims at determining the optimal delivery route of a chemotherapeutic (anti-angiogenic) drug Cedarinib and a photosensitizer, Verteporfin. The study was design to compare the encapsulated form of these agents when administered separately in two different nanoparticles or when both the drugs are administered together in single nanosystem. The results showed that the co-administration of these drugs using separate nanoparticles for each drug showed greater therapeutic efficiency in vitro.

ISBN: 9781392265482Subjects--Topical Terms:

657580
Bioengineering.

Drug Delivery Systems and Combination Therapy for Oncomedicine.
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500 $a Source: Dissertations Abstracts International, Volume: 80-12, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
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