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Assessing the Role of PTEN in Cholin...

Rapps, Joshua.

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Assessing the Role of PTEN in Cholinergic Neurons in Glucose and Energy Homeostasis.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Assessing the Role of PTEN in Cholinergic Neurons in Glucose and Energy Homeostasis./
Author:	Rapps, Joshua.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	109 p.
Notes:	Source: Masters Abstracts International, Volume: 80-05.
Contained By:	Masters Abstracts International80-05.
Subject:	Neurosciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10933891
ISBN:	9780438671317

Assessing the Role of PTEN in Cholinergic Neurons in Glucose and Energy Homeostasis.
Rapps, Joshua.

Assessing the Role of PTEN in Cholinergic Neurons in Glucose and Energy Homeostasis. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 109 p.

Source: Masters Abstracts International, Volume: 80-05.

Thesis (M.Sc.)--University of Toronto (Canada), 2018.

This item must not be sold to any third party vendors.

Insulin resistance and insulin deficiency are key determinants of type 2 diabetes. Insulin resistance is manifested by attenuation of insulin signaling. A major insulin signaling pathway is mediated by phosphatidyl inositol kinase (PI3K), which is negatively regulated by phosphatase and tensin homologue (PTEN). Neuronal PI3K-mediated insulin action plays a critical role in the regulation of systemic insulin resistance. The dorsal ventral complex (DVC) is the control centre of vagal activity and utilizes acetylcholine, a neurotransmitter, which is synthesized by the enzyme choline acetyl transferase (ChAT). To assess the role of PTEN in cholinergic neurons, we generated mice deficient of PTEN in these neurons using the cre-loxP system. These mice were protected against high fat diet-induced weight gain and glucose intolerance. They also had less inflammatory adipose tissue. Overall, PTEN deletion in the cholinergic neurons provides protection against diet-induced obesity and diabetes.

ISBN: 9780438671317Subjects--Topical Terms:

588700
Neurosciences.

Assessing the Role of PTEN in Cholinergic Neurons in Glucose and Energy Homeostasis.
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245 1 0 $a Assessing the Role of PTEN in Cholinergic Neurons in Glucose and Energy Homeostasis.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2018
300 $a 109 p.
500 $a Source: Masters Abstracts International, Volume: 80-05.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Woo, Minna.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2018.
506 $a This item must not be sold to any third party vendors.
520 $a Insulin resistance and insulin deficiency are key determinants of type 2 diabetes. Insulin resistance is manifested by attenuation of insulin signaling. A major insulin signaling pathway is mediated by phosphatidyl inositol kinase (PI3K), which is negatively regulated by phosphatase and tensin homologue (PTEN). Neuronal PI3K-mediated insulin action plays a critical role in the regulation of systemic insulin resistance. The dorsal ventral complex (DVC) is the control centre of vagal activity and utilizes acetylcholine, a neurotransmitter, which is synthesized by the enzyme choline acetyl transferase (ChAT). To assess the role of PTEN in cholinergic neurons, we generated mice deficient of PTEN in these neurons using the cre-loxP system. These mice were protected against high fat diet-induced weight gain and glucose intolerance. They also had less inflammatory adipose tissue. Overall, PTEN deletion in the cholinergic neurons provides protection against diet-induced obesity and diabetes.
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