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Hardware Development for Multi-Scale...

Cox, Benjamin L.

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Hardware Development for Multi-Scale Medical Imaging.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Hardware Development for Multi-Scale Medical Imaging./
Author:	Cox, Benjamin L.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	197 p.
Notes:	Source: Dissertations Abstracts International, Volume: 79-11, Section: B.
Contained By:	Dissertations Abstracts International79-11B.
Subject:	Design. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10821938
ISBN:	9780355947731

Hardware Development for Multi-Scale Medical Imaging.
Cox, Benjamin L.

Hardware Development for Multi-Scale Medical Imaging. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 197 p.

Source: Dissertations Abstracts International, Volume: 79-11, Section: B.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2018.

This item must not be sold to any third party vendors.

Medical imaging has provided countless new ways for researchers and clinicians to investigate their patients and research subjects. However, challenges and inefficiencies remain in the way these modalities are run and work with each other. The goal of this work is to leverage advanced fabrication techniques to develop hardware tools that address these challenges by both allowing for multiscale imaging across modalities and making standard imaging procedures more efficient and safer to conduct. Specifically, challenges in multiscale imaging are addressed in vitro through the development of a bioreactor for combined magnetic resonance spectroscopy and fluorescence lifetime imaging microscopy. Challenges in multiscale imaging are addressed in vivo through the development of mammary imaging windows and a pilot study testing them with a murine model of breast cancer. Finally, inefficiencies in standard imaging and calibration procedures are addressed through the development and testing of four novel imaging phantoms, including a preclinical MRI phantom, a preclinical PET calibration phantom, a clinical PET calibration phantom and a preclinical PET phantom for partial volume corrections. Novel hardware is only as good as its accessibility to end users and other developers. Therefore, a secondary goal of this work is to make accessible as many tools as possible for the easy recreation of any piece of hardware presented. Detailed part drawings of each custom part, files necessary for fabrication of components and descriptions and procedures of their use are all included. Finally, many of these tools have been published, creating an open record of their development and encouraging their future use and iteration.

ISBN: 9780355947731Subjects--Topical Terms:

518875
Design.

Hardware Development for Multi-Scale Medical Imaging.
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520 $a Medical imaging has provided countless new ways for researchers and clinicians to investigate their patients and research subjects. However, challenges and inefficiencies remain in the way these modalities are run and work with each other. The goal of this work is to leverage advanced fabrication techniques to develop hardware tools that address these challenges by both allowing for multiscale imaging across modalities and making standard imaging procedures more efficient and safer to conduct. Specifically, challenges in multiscale imaging are addressed in vitro through the development of a bioreactor for combined magnetic resonance spectroscopy and fluorescence lifetime imaging microscopy. Challenges in multiscale imaging are addressed in vivo through the development of mammary imaging windows and a pilot study testing them with a murine model of breast cancer. Finally, inefficiencies in standard imaging and calibration procedures are addressed through the development and testing of four novel imaging phantoms, including a preclinical MRI phantom, a preclinical PET calibration phantom, a clinical PET calibration phantom and a preclinical PET phantom for partial volume corrections. Novel hardware is only as good as its accessibility to end users and other developers. Therefore, a secondary goal of this work is to make accessible as many tools as possible for the easy recreation of any piece of hardware presented. Detailed part drawings of each custom part, files necessary for fabrication of components and descriptions and procedures of their use are all included. Finally, many of these tools have been published, creating an open record of their development and encouraging their future use and iteration.
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