東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Developing Photoacoustic Tomography ...

Wong, Terence Tsz Wai.

FindBook

Google Book

Amazon

博客來

Developing Photoacoustic Tomography Devices for Translational Medicine and Basic Science Research.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Developing Photoacoustic Tomography Devices for Translational Medicine and Basic Science Research./
作者:	Wong, Terence Tsz Wai.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:	100 p.
附註:	Source: Dissertations Abstracts International, Volume: 79-11, Section: B.
Contained By:	Dissertations Abstracts International79-11B.
標題:	Biomedical engineering. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10790892
ISBN:	9780355854794

Developing Photoacoustic Tomography Devices for Translational Medicine and Basic Science Research.
Wong, Terence Tsz Wai.

Developing Photoacoustic Tomography Devices for Translational Medicine and Basic Science Research. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 100 p.

Source: Dissertations Abstracts International, Volume: 79-11, Section: B.

Thesis (Ph.D.)--Washington University in St. Louis, 2018.

This item must not be sold to any third party vendors.

Photoacoustic (PA) tomography (PAT) provides volumetric images of biological tissue with scalable spatial resolutions and imaging depths, while preserving the same imaging contrast-optical absorption. Taking the advantage of its 100% sensitivity to optical absorption, PAT has been widely applied in structural, functional, and molecular imaging, with both endogenous and exogenous contrasts, at superior depths than pure optical methods. Intuitively, hemoglobin has been the most commonly studied biomolecule in PAT due to its strong absorption in the visible wavelength regime. One of the main focuses of this dissertation is to investigate an underexplored wavelength regime-ultraviolet (UV), which allows us to image cell nuclei without labels and generate histology-like images naturally from unprocessed biological tissue. These preparation-free and easy-to-interpret characteristics open up new possibilities for PAT to become readily applicable to other important biomedical problems (e.g., surgical margin analysis, Chapter 2) or basic science studies (e.g., whole-organ imaging, Chapter 3). For instance, we developed and optimized a PA microscopy system with UV laser illumination (UV-PAM) to achieve fast, label-free, multilayered, and histology-like imaging of human breast cancer in Chapter 2. These imaging abilities are essential to intraoperative surgical margin analysis, which enables promptly directed re-excision and reduces the number of repeat surgeries. We have incorporated the Gruneisen relaxation (GR) effect with UV-PAM to improve the performance of our UV-PAM system (e.g., the axial resolution), thus providing more accurate three-dimensional (3D) information (Chapter 4). The nonlinear PA signals caused by the GR effect enable optical sectioning capability, revealing important 3D cell nuclear distributions and internal structures for cancer diagnosis. In the final focus of this dissertation, we have implemented a low-cost PA computed tomography (PACT) system with a single xenon flash lamp as the illumination source (Chapter 5). Lasers have been commonly used as illumination light sources in PACT. However, lasers are usually expensive and bulky, limiting their applicability in many clinical usages. Therefore, the use of a single xenon flash lamp as an alternative light source was explored. We found that PACT images acquired with flash lamp illumination were comparable to those acquired with laser illumination. This low-cost and portable PACT system opens up new potentials, such as low-cost skin melanoma imaging in undeveloped countries.

ISBN: 9780355854794Subjects--Topical Terms:

535387
Biomedical engineering.

Developing Photoacoustic Tomography Devices for Translational Medicine and Basic Science Research.
LDR:03713nmm a2200337 4500 001 2207560
005 20190920131251.5
008 201008s2018 ||||||||||||||||| ||eng d
020 $a 9780355854794
035 $a (MiAaPQ)AAI10790892
035 $a (MiAaPQ)wustl:12475
035 $a AAI10790892
040 $a MiAaPQ $c MiAaPQ
100 1 $a Wong, Terence Tsz Wai. $3 3434545
245 1 0 $a Developing Photoacoustic Tomography Devices for Translational Medicine and Basic Science Research.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2018
300 $a 100 p.
500 $a Source: Dissertations Abstracts International, Volume: 79-11, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Wang, Lihong V.
502 $a Thesis (Ph.D.)--Washington University in St. Louis, 2018.
506 $a This item must not be sold to any third party vendors.
520 $a Photoacoustic (PA) tomography (PAT) provides volumetric images of biological tissue with scalable spatial resolutions and imaging depths, while preserving the same imaging contrast-optical absorption. Taking the advantage of its 100% sensitivity to optical absorption, PAT has been widely applied in structural, functional, and molecular imaging, with both endogenous and exogenous contrasts, at superior depths than pure optical methods. Intuitively, hemoglobin has been the most commonly studied biomolecule in PAT due to its strong absorption in the visible wavelength regime. One of the main focuses of this dissertation is to investigate an underexplored wavelength regime-ultraviolet (UV), which allows us to image cell nuclei without labels and generate histology-like images naturally from unprocessed biological tissue. These preparation-free and easy-to-interpret characteristics open up new possibilities for PAT to become readily applicable to other important biomedical problems (e.g., surgical margin analysis, Chapter 2) or basic science studies (e.g., whole-organ imaging, Chapter 3). For instance, we developed and optimized a PA microscopy system with UV laser illumination (UV-PAM) to achieve fast, label-free, multilayered, and histology-like imaging of human breast cancer in Chapter 2. These imaging abilities are essential to intraoperative surgical margin analysis, which enables promptly directed re-excision and reduces the number of repeat surgeries. We have incorporated the Gruneisen relaxation (GR) effect with UV-PAM to improve the performance of our UV-PAM system (e.g., the axial resolution), thus providing more accurate three-dimensional (3D) information (Chapter 4). The nonlinear PA signals caused by the GR effect enable optical sectioning capability, revealing important 3D cell nuclear distributions and internal structures for cancer diagnosis. In the final focus of this dissertation, we have implemented a low-cost PA computed tomography (PACT) system with a single xenon flash lamp as the illumination source (Chapter 5). Lasers have been commonly used as illumination light sources in PACT. However, lasers are usually expensive and bulky, limiting their applicability in many clinical usages. Therefore, the use of a single xenon flash lamp as an alternative light source was explored. We found that PACT images acquired with flash lamp illumination were comparable to those acquired with laser illumination. This low-cost and portable PACT system opens up new potentials, such as low-cost skin melanoma imaging in undeveloped countries.
590 $a School code: 0252.
650 4 $a Biomedical engineering. $3 535387
650 4 $a Medical imaging. $3 3172799
650 4 $a Optics. $3 517925
690 $a 0541
690 $a 0574
690 $a 0752
710 2 $a Washington University in St. Louis. $b Biomedical Engineering. $3 1669544
773 0 $t Dissertations Abstracts International $g 79-11B.
790 $a 0252
791 $a Ph.D.
792 $a 2018
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10790892