東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Nanoparticles: Nanoscale Systems for...

Wadkins, David Allen.

FindBook

Google Book

Amazon

博客來

Nanoparticles: Nanoscale Systems for Medical Applications.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Nanoparticles: Nanoscale Systems for Medical Applications./
作者:	Wadkins, David Allen.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2017,
面頁冊數:	102 p.
附註:	Source: Masters Abstracts International, Volume: 79-09.
Contained By:	Masters Abstracts International79-09.
標題:	Pharmacology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10640459
ISBN:	9780355659740

Nanoparticles: Nanoscale Systems for Medical Applications.
Wadkins, David Allen.

Nanoparticles: Nanoscale Systems for Medical Applications. - Ann Arbor : ProQuest Dissertations & Theses, 2017 - 102 p.

Source: Masters Abstracts International, Volume: 79-09.

Thesis (M.S.)--The University of Iowa, 2017.

This item must not be added to any third party search indexes.

The goal of this project was to develop a series of nano platforms for single cell analysis and drug delivery. Nanoparticles are a promising option to improve our medical therapies by controlling biodistribution and pharmacokinetics of therapeutics. Nanosystems also offer significant opportunity to improve current imaging modalities. The systems developed during this thesis work can be foundations for developing advanced therapies for obesity and improving our fundamental understandings of single cell behavior. The first of the two systems we attempt to create was a drug delivery system that could selectively target adipose tissue to deliver uncoupling agents and drive browning of adipose tissue and associated weight loss. Protonophores have a history of significant toxic side effects in cardiac and neuronal tissues a recently discovered protonophore, but BAM-15, has been shown to have reduced cytotoxicity. We hypothesized that the altered biodistribution of BAM-15 encapsulated in a nanoparticle could provide systemic weight loss with minimized side effects. The second system developed utilized quantum dots to create a fluorescent barcode that could be repeatedly identified using quantitative fluorescent emission readings. This platform would allow for the tracking of individual cells, allowing repeat interrogation across time and space in complex multicellular environments. Ultimately this work demonstrates the process and complexity involved in developing nanoparticulate systems meant to interact with incredibly complex intracellular environments.

ISBN: 9780355659740Subjects--Topical Terms:

634543
Pharmacology.

Nanoparticles: Nanoscale Systems for Medical Applications.
LDR:02727nmm a2200361 4500 001 2207528
005 20190920131246.5
008 201008s2017 ||||||||||||||||| ||eng d
020 $a 9780355659740
035 $a (MiAaPQ)AAI10640459
035 $a (MiAaPQ)uiowa:15414
035 $a AAI10640459
040 $a MiAaPQ $c MiAaPQ
100 1 $a Wadkins, David Allen. $3 3434515
245 1 0 $a Nanoparticles: Nanoscale Systems for Medical Applications.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2017
300 $a 102 p.
500 $a Source: Masters Abstracts International, Volume: 79-09.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Ankrum, James A.
502 $a Thesis (M.S.)--The University of Iowa, 2017.
506 $a This item must not be added to any third party search indexes.
506 $a This item must not be sold to any third party vendors.
520 $a The goal of this project was to develop a series of nano platforms for single cell analysis and drug delivery. Nanoparticles are a promising option to improve our medical therapies by controlling biodistribution and pharmacokinetics of therapeutics. Nanosystems also offer significant opportunity to improve current imaging modalities. The systems developed during this thesis work can be foundations for developing advanced therapies for obesity and improving our fundamental understandings of single cell behavior. The first of the two systems we attempt to create was a drug delivery system that could selectively target adipose tissue to deliver uncoupling agents and drive browning of adipose tissue and associated weight loss. Protonophores have a history of significant toxic side effects in cardiac and neuronal tissues a recently discovered protonophore, but BAM-15, has been shown to have reduced cytotoxicity. We hypothesized that the altered biodistribution of BAM-15 encapsulated in a nanoparticle could provide systemic weight loss with minimized side effects. The second system developed utilized quantum dots to create a fluorescent barcode that could be repeatedly identified using quantitative fluorescent emission readings. This platform would allow for the tracking of individual cells, allowing repeat interrogation across time and space in complex multicellular environments. Ultimately this work demonstrates the process and complexity involved in developing nanoparticulate systems meant to interact with incredibly complex intracellular environments.
590 $a School code: 0096.
650 4 $a Pharmacology. $3 634543
650 4 $a Biomedical engineering. $3 535387
650 4 $a Medical imaging. $3 3172799
650 4 $a Nanotechnology. $3 526235
690 $a 0419
690 $a 0541
690 $a 0574
690 $a 0652
710 2 $a The University of Iowa. $b Biomedical Engineering. $3 1679996
773 0 $t Masters Abstracts International $g 79-09.
790 $a 0096
791 $a M.S.
792 $a 2017
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10640459