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Decreased Face Primary Motor Cortex ...

Awamleh, Laith.

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Decreased Face Primary Motor Cortex (Face-M1) Excitability Induced by Noxious Stimulation of the Molar Tooth Pulp is Dependent on the Functional Integrity of Face-M1 Astrocytes.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Decreased Face Primary Motor Cortex (Face-M1) Excitability Induced by Noxious Stimulation of the Molar Tooth Pulp is Dependent on the Functional Integrity of Face-M1 Astrocytes./
Author:	Awamleh, Laith.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2014,
Description:	108 p.
Notes:	Source: Masters Abstracts International, Volume: 76-07.
Contained By:	Masters Abstracts International76-07.
Subject:	Dentistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1572030
ISBN:	9781321454116

Decreased Face Primary Motor Cortex (Face-M1) Excitability Induced by Noxious Stimulation of the Molar Tooth Pulp is Dependent on the Functional Integrity of Face-M1 Astrocytes.
Awamleh, Laith.

Decreased Face Primary Motor Cortex (Face-M1) Excitability Induced by Noxious Stimulation of the Molar Tooth Pulp is Dependent on the Functional Integrity of Face-M1 Astrocytes. - Ann Arbor : ProQuest Dissertations & Theses, 2014 - 108 p.

Source: Masters Abstracts International, Volume: 76-07.

Thesis (M.Sc.)--University of Toronto (Canada), 2014.

This item must not be sold to any third party vendors.

Acute inflammatory dental pain is a prevalent orofacial pain condition that is often associated with altered orofacial sensorimotor functions. The underlying motor cortex mechanisms are unclear. The aims were to examine whether application of the inflammatory irritant mustard oil (MO) to the rat maxillary molar tooth pulp affects face-M1 excitability manifested as a change in intracortical microstimulation threshold intensity for evoking jaw-opening muscle electromyographic activity, and if subsequent application of the astrocytic inhibitor methionine sulfoximine (MSO) to the face-M1 can modulate the MO-induced effects. Compared with control, pulpal MO application induced significantly decreased face-M1 excitability. Subsequent MSO application to the face-M1 attenuated the MO-induced effects. These novel findings suggest that acute noxious stimulation of the dental pulp is associated with decreased face-M1 excitability that is, at least in part, dependent on the functional integrity of face-M1 astrocytes and may be related to mechanisms underlying limited jaw movements in acute pain conditions.

ISBN: 9781321454116Subjects--Topical Terms:

828971
Dentistry.

Decreased Face Primary Motor Cortex (Face-M1) Excitability Induced by Noxious Stimulation of the Molar Tooth Pulp is Dependent on the Functional Integrity of Face-M1 Astrocytes.
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100 1 $a Awamleh, Laith. $3 3434297
245 1 0 $a Decreased Face Primary Motor Cortex (Face-M1) Excitability Induced by Noxious Stimulation of the Molar Tooth Pulp is Dependent on the Functional Integrity of Face-M1 Astrocytes.
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500 $a Publisher info.: Dissertation/Thesis.
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502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2014.
506 $a This item must not be sold to any third party vendors.
520 $a Acute inflammatory dental pain is a prevalent orofacial pain condition that is often associated with altered orofacial sensorimotor functions. The underlying motor cortex mechanisms are unclear. The aims were to examine whether application of the inflammatory irritant mustard oil (MO) to the rat maxillary molar tooth pulp affects face-M1 excitability manifested as a change in intracortical microstimulation threshold intensity for evoking jaw-opening muscle electromyographic activity, and if subsequent application of the astrocytic inhibitor methionine sulfoximine (MSO) to the face-M1 can modulate the MO-induced effects. Compared with control, pulpal MO application induced significantly decreased face-M1 excitability. Subsequent MSO application to the face-M1 attenuated the MO-induced effects. These novel findings suggest that acute noxious stimulation of the dental pulp is associated with decreased face-M1 excitability that is, at least in part, dependent on the functional integrity of face-M1 astrocytes and may be related to mechanisms underlying limited jaw movements in acute pain conditions.
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