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An Optical Stimulation Cuff for Use ...

Hogan, Laura Kathryn.

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An Optical Stimulation Cuff for Use in Rodent Peripheral Nerves toward Control of an Advanced Prosthesis.

Record Type:	Electronic resources : Monograph/item
Title/Author:	An Optical Stimulation Cuff for Use in Rodent Peripheral Nerves toward Control of an Advanced Prosthesis./
Author:	Hogan, Laura Kathryn.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	81 p.
Notes:	Source: Masters Abstracts International, Volume: 80-07.
Contained By:	Masters Abstracts International80-07.
Subject:	Bioengineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13420039
ISBN:	9780438768826

An Optical Stimulation Cuff for Use in Rodent Peripheral Nerves toward Control of an Advanced Prosthesis.
Hogan, Laura Kathryn.

An Optical Stimulation Cuff for Use in Rodent Peripheral Nerves toward Control of an Advanced Prosthesis. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 81 p.

Source: Masters Abstracts International, Volume: 80-07.

Thesis (M.Eng.)--University of Colorado at Denver, 2018.

This item must not be sold to any third party vendors.

The purpose of this research was to create an LED-based stimulation cuff that could be implanted around a mouse sciatic nerve. Currently available prosthetic devices lack sensory feedback, which is necessary for embodiment of the limb; this causes a high rejection rate, especially among upper-limb unilateral distal prosthesis users. Sensory feedback has been shown in several studies to increase ownership and usefulness of the limb. Electrical stimulation has largely been used in humans, with some success. However, electrical nerve stimulation implants have several drawbacks, chief among them non-specificity. Thus, the field of optogenetics is useful for this application, since it allows for subsets of axons to be targeted and preferentially activated using light and light-sensitive proteins. In this study, an implantable nerve cuff was designed and iterated. The final design, including three LEDs, was implanted around transgenic mouse sciatic nerves, and stimulation was applied. Compound action potentials were recorded and compared to recordings from electrical stimulation. These experiments found that this cuff could be a viable alternative to electrical stimulation, especially should it be improved, due to optogenetics' advantage of selective stimulation. However, further experiments and validation must be performed.

ISBN: 9780438768826Subjects--Topical Terms:

657580
Bioengineering.

An Optical Stimulation Cuff for Use in Rodent Peripheral Nerves toward Control of an Advanced Prosthesis.
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245 1 3 $a An Optical Stimulation Cuff for Use in Rodent Peripheral Nerves toward Control of an Advanced Prosthesis.
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502 $a Thesis (M.Eng.)--University of Colorado at Denver, 2018.
506 $a This item must not be sold to any third party vendors.
520 $a The purpose of this research was to create an LED-based stimulation cuff that could be implanted around a mouse sciatic nerve. Currently available prosthetic devices lack sensory feedback, which is necessary for embodiment of the limb; this causes a high rejection rate, especially among upper-limb unilateral distal prosthesis users. Sensory feedback has been shown in several studies to increase ownership and usefulness of the limb. Electrical stimulation has largely been used in humans, with some success. However, electrical nerve stimulation implants have several drawbacks, chief among them non-specificity. Thus, the field of optogenetics is useful for this application, since it allows for subsets of axons to be targeted and preferentially activated using light and light-sensitive proteins. In this study, an implantable nerve cuff was designed and iterated. The final design, including three LEDs, was implanted around transgenic mouse sciatic nerves, and stimulation was applied. Compound action potentials were recorded and compared to recordings from electrical stimulation. These experiments found that this cuff could be a viable alternative to electrical stimulation, especially should it be improved, due to optogenetics' advantage of selective stimulation. However, further experiments and validation must be performed.
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