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Optical Sensors for Detection of Ena...

Sheykhi, Sara.

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Optical Sensors for Detection of Enantiomeric Excess Application.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Optical Sensors for Detection of Enantiomeric Excess Application./
作者:	Sheykhi, Sara.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
面頁冊數:	286 p.
附註:	Source: Dissertation Abstracts International, Volume: 80-09(E), Section: B.
Contained By:	Dissertation Abstracts International80-09B(E).
標題:	Chemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13893957
ISBN:	9781392125632

Optical Sensors for Detection of Enantiomeric Excess Application.
Sheykhi, Sara.

Optical Sensors for Detection of Enantiomeric Excess Application. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 286 p.

Source: Dissertation Abstracts International, Volume: 80-09(E), Section: B.

Thesis (Ph.D.)--Bowling Green State University, 2019.

Chiral compounds play an essential role in drug synthesis, biological chemistry, and asymmetric catalysis. More specifically, chiral carboxylates are extensively utilized in drug development processes, and many are commercialized as drugs. Synthesis of single enantiomer together with research in methods for chiral drug separation is now a central subject for pharmaceutical development. This is because opposite enantiomers frequently possess different pharmacological benefits and toxicity. Thus, the ability to determine enantiomeric excess in chiral compounds is important for the development of new chiral drugs. Supramolecular optical chemosensors are potentially important methods in many emerging medical technologies. Due to the rapidly developing fields of supramolecular chemistry and optical detection, new sensing approaches have been developed for the recognition of many essential molecules in aqueous solutions. Because of high sensitivity and low cost, fluorescence based sensors are gaining wide popularity for chemical trace detection.

ISBN: 9781392125632Subjects--Topical Terms:

516420
Chemistry.

Optical Sensors for Detection of Enantiomeric Excess Application.
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500 $a Source: Dissertation Abstracts International, Volume: 80-09(E), Section: B.
500 $a Adviser: Pavel Anzenbacher.
502 $a Thesis (Ph.D.)--Bowling Green State University, 2019.
520 $a Chiral compounds play an essential role in drug synthesis, biological chemistry, and asymmetric catalysis. More specifically, chiral carboxylates are extensively utilized in drug development processes, and many are commercialized as drugs. Synthesis of single enantiomer together with research in methods for chiral drug separation is now a central subject for pharmaceutical development. This is because opposite enantiomers frequently possess different pharmacological benefits and toxicity. Thus, the ability to determine enantiomeric excess in chiral compounds is important for the development of new chiral drugs. Supramolecular optical chemosensors are potentially important methods in many emerging medical technologies. Due to the rapidly developing fields of supramolecular chemistry and optical detection, new sensing approaches have been developed for the recognition of many essential molecules in aqueous solutions. Because of high sensitivity and low cost, fluorescence based sensors are gaining wide popularity for chemical trace detection.
520 $a In this dissertation, we present optical methods to determine the enantiomeric composition of chiral carboxylates and alpha-hydroxycarboxylic acids. We used enantioselective Indicator Displacement Assays (eIDAs) for the determination of enantiomeric excess of chiral carboxylates and alpha-hydroxycarboxylic acids. This chiral receptor-fluorophore sensing ensemble is shown to be useful in the determination of enantiomeric excess of alpha-hydroxycarboxylic acids and chiral carboxylates including non-steroidal anti-inflammatory drugs (NSAIDs).
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