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Regulatory Consequences of Interspec...

Kaufman, Brad Michael.

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Regulatory Consequences of Interspecific Gene Combinations in Plants.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Regulatory Consequences of Interspecific Gene Combinations in Plants./
Author:	Kaufman, Brad Michael.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2017,
Description:	68 p.
Notes:	Source: Dissertation Abstracts International, Volume: 78-10(E), Section: B.
Contained By:	Dissertation Abstracts International78-10B(E).
Subject:	Bioinformatics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10241478
ISBN:	9781369795332

Regulatory Consequences of Interspecific Gene Combinations in Plants.
Kaufman, Brad Michael.

Regulatory Consequences of Interspecific Gene Combinations in Plants. - Ann Arbor : ProQuest Dissertations & Theses, 2017 - 68 p.

Source: Dissertation Abstracts International, Volume: 78-10(E), Section: B.

Thesis (Ph.D.)--University of California, Davis, 2017.

Mechanisms underlying the phenotype of hybrids have basic and applied significance. The progeny of two diverged individuals often displays heterosis, manifested as greater vigor, yield and stress tolerance. Heterosis is key to the evolutionary potential of allopolyploids, which fix hybridity through maintenance of dual genomes. In apparent contrast to their hybrid vigor, many allopolyploids have increased stress gene expression. The regulatory events leading to stress are unclear. One possibility is that the superimposition of two diverged regulatory networks engenders stress. Stress in this case should be proportional to the number of diverged genes in the hybrid. Alternatively stress may result from epistatic interactions between few, specific loci, as predicted by Bateson-Dobzhansky-Muller (BDM) model, and stress responses should derive from few QTL. In both cases, the contribution of cis-regulatory versus trans-regulatory evolution is unclear.

ISBN: 9781369795332Subjects--Topical Terms:

553671
Bioinformatics.

Regulatory Consequences of Interspecific Gene Combinations in Plants.
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245 1 0 $a Regulatory Consequences of Interspecific Gene Combinations in Plants.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2017
300 $a 68 p.
500 $a Source: Dissertation Abstracts International, Volume: 78-10(E), Section: B.
500 $a Includes supplementary digital materials.
500 $a Adviser: Luca Comai.
502 $a Thesis (Ph.D.)--University of California, Davis, 2017.
520 $a Mechanisms underlying the phenotype of hybrids have basic and applied significance. The progeny of two diverged individuals often displays heterosis, manifested as greater vigor, yield and stress tolerance. Heterosis is key to the evolutionary potential of allopolyploids, which fix hybridity through maintenance of dual genomes. In apparent contrast to their hybrid vigor, many allopolyploids have increased stress gene expression. The regulatory events leading to stress are unclear. One possibility is that the superimposition of two diverged regulatory networks engenders stress. Stress in this case should be proportional to the number of diverged genes in the hybrid. Alternatively stress may result from epistatic interactions between few, specific loci, as predicted by Bateson-Dobzhansky-Muller (BDM) model, and stress responses should derive from few QTL. In both cases, the contribution of cis-regulatory versus trans-regulatory evolution is unclear.
520 $a Introgression lines provide combinations of diverged parental genomes and should be useful to explore these phenomena. Here we compare expression data across 76 individual introgression lines, S. pennellii in S. lycopersicum, by a simple random resampling method. We find that less than 10% of the tomato ILs are stressed, and that the amount of stress is unrelated to the number of genes or heterochromatin introgressed. Therefore, stress is a result of epistatic interactions of few loci consistent with the BDM prediction. In at least two stress QTL, overlapping introgressions suggest a linked suppressor effect. Furthermore, in most ILs genes located within the introgression are preferentially mis-expressed. This is consistent with evolution of cis-elements (rather than trans-elements) between the two parental species.
520 $a Arabidopsis thaliana is a useful plant to study because of its short generation time from seed to seed and small size. It also hybridizes with Arabidopsis arenosa in nature. However, this hybridization is not fully favorable; many of the hybrid seeds die before maturity. In this project, we analyze the transcriptome of A. thaliana X A. arenosa hybrid tissues (seedling, leaf, and flower) that have survived past seed maturity and germinate into visually healthy plants. We show that in the seedling, while it does not appear to be stressed, there is some misregulation of lipid localization genes. The leaf and flower tissues do show enrichment of stress gene expression in the hybrid.
590 $a School code: 0029.
650 4 $a Bioinformatics. $3 553671
650 4 $a Plant sciences. $3 3173832
650 4 $a Biology. $3 522710
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710 2 $a University of California, Davis. $b Plant Biology. $3 1676788
773 0 $t Dissertation Abstracts International $g 78-10B(E).
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791 $a Ph.D.
792 $a 2017
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10241478