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The Role of Maternal Covariates on I...

Knapp, Madeleine.

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The Role of Maternal Covariates on Infant Respiratory Distress.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The Role of Maternal Covariates on Infant Respiratory Distress./
Author:	Knapp, Madeleine.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2017,
Description:	25 p.
Notes:	Source: Masters Abstracts International, Volume: 79-11.
Contained By:	Masters Abstracts International79-11.
Subject:	Environmental Health. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10277254
ISBN:	9780355777604

The Role of Maternal Covariates on Infant Respiratory Distress.
Knapp, Madeleine.

The Role of Maternal Covariates on Infant Respiratory Distress. - Ann Arbor : ProQuest Dissertations & Theses, 2017 - 25 p.

Source: Masters Abstracts International, Volume: 79-11.

Thesis (M.P.H.)--Yale University, 2017.

This item must not be sold to any third party vendors.

BACKGROUND AND OBJECTIVES: Respiratory distress syndrome (RDS) has been reported to affect between 1-7% of all newborns, regardless of gestational age [1-4]. The main objective was to examine maternal risk factors such as age, body mass index (BMI), race/ethnicity, smoking status, and hypertension and their potential impacts on the presence of RDS and subsequent duration of respiratory support among infants with RDS. METHODS: Data from Yale New Haven Hospital was analyzed from 2012-2016, with information from n = 1,692 uncomplicated, singleton mother-baby pairs included. Univariate analysis was performed to first identify significant differences between infants with and without RDS. Multiple logistic regression then modeled all covariates to determine which maternal characteristics impact the presence of RDS among infants. Lastly, a Cox regression model was implemented to analyze which maternal covariates impacted the "time to event", which was end of respirator use. Two gestational age categories were analyzed based on published literature. RESULTS: We found that maternal smoking (p = 0.0347), race/ethnicity (p = 0.0318), and hypertension (p = 0.0651) were distinct between RDS and no RDS infants in our univariate analysis, but none of these variables were significant in determining the presence of RDS in the multiple logistic regression model. The average length of time required for respiratory support for RDS was approximately 2.5 times longer for infants born <35 weeks of gestation, compared to those born in the 35-37 weeks of gestation time frame (p < 0.0001). CONCLUSION: The 6-day average, total time needed on any form of respiratory assist for infants born 35-37 weeks of gestation provides a target for global health that could have the greatest impact to inform device development domestically and in a global setting. Future research is warranted to identify the cause of high variation of length of time on a respirator.

ISBN: 9780355777604Subjects--Topical Terms:

578282
Environmental Health.

The Role of Maternal Covariates on Infant Respiratory Distress.
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300 $a 25 p.
500 $a Source: Masters Abstracts International, Volume: 79-11.
500 $a Publisher info.: Dissertation/Thesis.
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520 $a BACKGROUND AND OBJECTIVES: Respiratory distress syndrome (RDS) has been reported to affect between 1-7% of all newborns, regardless of gestational age [1-4]. The main objective was to examine maternal risk factors such as age, body mass index (BMI), race/ethnicity, smoking status, and hypertension and their potential impacts on the presence of RDS and subsequent duration of respiratory support among infants with RDS. METHODS: Data from Yale New Haven Hospital was analyzed from 2012-2016, with information from n = 1,692 uncomplicated, singleton mother-baby pairs included. Univariate analysis was performed to first identify significant differences between infants with and without RDS. Multiple logistic regression then modeled all covariates to determine which maternal characteristics impact the presence of RDS among infants. Lastly, a Cox regression model was implemented to analyze which maternal covariates impacted the "time to event", which was end of respirator use. Two gestational age categories were analyzed based on published literature. RESULTS: We found that maternal smoking (p = 0.0347), race/ethnicity (p = 0.0318), and hypertension (p = 0.0651) were distinct between RDS and no RDS infants in our univariate analysis, but none of these variables were significant in determining the presence of RDS in the multiple logistic regression model. The average length of time required for respiratory support for RDS was approximately 2.5 times longer for infants born <35 weeks of gestation, compared to those born in the 35-37 weeks of gestation time frame (p < 0.0001). CONCLUSION: The 6-day average, total time needed on any form of respiratory assist for infants born 35-37 weeks of gestation provides a target for global health that could have the greatest impact to inform device development domestically and in a global setting. Future research is warranted to identify the cause of high variation of length of time on a respirator.
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