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DNA systems under internal and exter...

Engel, Megan Clare.

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DNA systems under internal and external forcing = an exploration using coarse-grained modelling /

Record Type:	Electronic resources : Monograph/item
Title/Author:	DNA systems under internal and external forcing/ by Megan Clare Engel.
Reminder of title:	an exploration using coarse-grained modelling /
Author:	Engel, Megan Clare.
Published:	Cham :Springer International Publishing : : 2019.,
Description:	xv, 144 p. :ill., digital ;24 cm.
[NT 15003449]:	Introduction -- Simulation Methods -- Non-equilibrium bio-molecular unfolding under tension -- Force-induced unravelling of DNA origami -- Measuring internal forces in single-stranded DNA -- Conclusions -- Appendices.
Contained By:	Springer eBooks
Subject:	DNA - Analysis. -
Online resource:	https://doi.org/10.1007/978-3-030-25413-1
ISBN:	9783030254131

DNA systems under internal and external forcing = an exploration using coarse-grained modelling /
Engel, Megan Clare.

DNA systems under internal and external forcingan exploration using coarse-grained modelling /[electronic resource] :by Megan Clare Engel. - Cham :Springer International Publishing :2019. - xv, 144 p. :ill., digital ;24 cm. - Springer theses,2190-5053. - Springer theses..

Introduction -- Simulation Methods -- Non-equilibrium bio-molecular unfolding under tension -- Force-induced unravelling of DNA origami -- Measuring internal forces in single-stranded DNA -- Conclusions -- Appendices.

The interactions of DNA with force are central to manifold fields of inquiry, including the de novo design of DNA nanostructures, the use of DNA to probe the principles of biological self-assembly, and the operation of cellular nanomachines. This work presents a survey of three distinct ways coarse-grained simulations can help characterize these interactions. A non-equilibrium energy landscape reconstruction technique is validated for use with the oxDNA model and a practical framework to guide future applications is established. A novel method for calculating entropic forces in DNA molecules is outlined and contrasted with existing, flawed approaches. Finally, a joint experimental-simulation study of large DNA origami nanostructures under force sheds light on design principles and, through vivid illustrations, their unfolding process. This text provides an accessible and exciting launching point for any student interested in the computational study of DNA mechanics and force interactions.

ISBN: 9783030254131

Standard No.: 10.1007/978-3-030-25413-1doiSubjects--Topical Terms:

600606
DNA
--Analysis.

LC Class. No.: QP624 / .E544 2019

Dewey Class. No.: 572.86

DNA systems under internal and external forcing = an exploration using coarse-grained modelling /
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520 $a The interactions of DNA with force are central to manifold fields of inquiry, including the de novo design of DNA nanostructures, the use of DNA to probe the principles of biological self-assembly, and the operation of cellular nanomachines. This work presents a survey of three distinct ways coarse-grained simulations can help characterize these interactions. A non-equilibrium energy landscape reconstruction technique is validated for use with the oxDNA model and a practical framework to guide future applications is established. A novel method for calculating entropic forces in DNA molecules is outlined and contrasted with existing, flawed approaches. Finally, a joint experimental-simulation study of large DNA origami nanostructures under force sheds light on design principles and, through vivid illustrations, their unfolding process. This text provides an accessible and exciting launching point for any student interested in the computational study of DNA mechanics and force interactions.
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