Medicinal chemistry = drug design an...
Haldane, Thomas,

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  • Medicinal chemistry = drug design and development /
  • 紀錄類型: 書目-電子資源 : Monograph/item
    正題名/作者: Medicinal chemistry/ Thomas Haldane.
    其他題名: drug design and development /
    其他作者: Haldane, Thomas,
    出版者: [New York] :World Technologies, : 2018.,
    面頁冊數: 1 online resource (232 p.)
    內容註: Medicinal chemistry: drug design and development -- Contents -- Preface -- Chapter 1. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A -- Chapter 2. Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids -- Chapter 3. The first total synthesis of the cyclodepsipeptide pipecolidepsin A -- Chapter 4. Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach -- Chapter 5. Ligand substitutions between ruthenium-cymene compounds can control protein versus DNA targeting and anticancer activity -- Chapter 6. Identifying the preferred RNA motifs and chemotypes that interact by probing millions of combinations -- Chapter 7. Stereochemical bias introduced during RNA synthesis modulates the activity of phosphorothioate siRNAs -- Chapter 8. Regioselective trifluoromethylation of N-heteroaromatic compounds using trifluoromethyldifluoroborane activator -- Chapter 9. Total synthesis of clostrubin -- Chapter 10. Downsizing a human inflammatory protein to a small molecule with equal potency and functionality -- Chapter 11. TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ9-tetrahydrocannabiorcol -- Chapter 12. De novo branching cascades for structural and functional diversity in small molecules -- Chapter 13. Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations -- Chapter 14. Solution-based circuits enable rapid and multiplexed pathogen detection -- Chapter 15. Total synthesis of periploside A, a unique pregnane hexasaccharide with potent immunosuppressive effects -- Chapter 16. In vivo time-gated fluorescence imaging with biodegradable luminescent porous silicon nanoparticles -- Chapter 17. Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate -- Chapter 18. Foldamer-mediated manipulation of a pre-amyloid toxin -- Chapter 19. Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds -- Chapter 20. In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics -- Chapter 21. Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity -- Chapter 22. Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity -- List of Contributors -- Index.
    標題: Pharmaceutical chemistry. -
    電子資源: http://portal.igpublish.com/iglibrary/search/WLDTECH0000838.htmlclick for full text
    ISBN: 9781978914063
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W9372749 電子資源 11.線上閱覽_V 電子書 EB RS403 .M43 2018 一般使用(Normal) 在架 0
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