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The molecular and cellular basis of ...

Wolfe, Michael S.,

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The molecular and cellular basis of neurodegenerative diseases : = underlying mechanisms /

Record Type:	Electronic resources : Monograph/item
Title/Author:	The molecular and cellular basis of neurodegenerative diseases :/ edited by Michael S. Wolfe.
Reminder of title:	underlying mechanisms /
other author:	Wolfe, Michael S.,
Description:	1 online resource
[NT 15003449]:	Front Cover; The Molecular and Cellular Basis of Neurodegenerative Diseases; Copyright Page; Dedication; Contents; List of Contributors; Preface; 1 Solving the Puzzle of Neurodegeneration; Introduction: The General Problem of Neurodegeneration; Epidemiology and Clinical Presentation; Molecular Pathology; Genetics; Molecular Clues to Mechanisms of Pathogenesis; Common Themes and Controversies in Neurodegeneration; Animal Models; Prospects for Therapeutics; Conclusions and Perspective; References; 2 Prion Diseases; Introduction and Historical Perspective.
[NT 15003449]:	3 Alzheimer's Disease: Toward a Quantitative Biological Approach in Describing its Natural History and Underlying MechanismsQuantitative Approach to Basic AD Demographics; Change Over Time: (i) Biogenesis, Production, and Turnover of AÝ; Change Over Time: (ii) The Accumulation, Spread, Propagation of AÝ; Change Over Time: (iii) The Growth and Accumulation of Plaque Cores; Change Over Time: (iv) Brain Atrophy; Change Over Time: (v) Cognition; Clearance Mechanisms and Impaired Phagocytosis; Calculating Polygenic Risk Scores.
[NT 15003449]:	Mitochondrial Energy ProductionRNA Metabolism; Axonal Dysfunction; Excitotoxicity; Oxidative Stress; Neuroinflammation; Other TDP-43 Proteinopathies; Frontotemporal Dementia; TDP-43 in Alzheimer's Disease and Parkinsonian Syndromes; Inclusion Body Myositis; Conclusions; References; 6 Parkinson's Disease and Other Synucleinopathies; Introduction: The Pathology of Parkinson's Disease; Protein Deposition; Aggregation of Ü-Synuclein in PD; The Broader Set of Synucleinopathies; Changes in Cellularity; Neuronal Loss; Reactive Gliosis; Genes Associated with Synucleinopathies.
[NT 15003449]:	Disease-Modifying Strategies: Models of AÝ Accumulation in Alzheimer's Disease-Implications for AÝ Amyloid-Targeting TherapiesReferences; 4 Neurodegeneration and the Ordered Assembly of Tau; Introduction; Tau Isoforms; Tau Aggregation; Genetics of MAPT; Propagation of Tau Aggregates; Strains of Aggregated Tau; Acknowledgments; References; Further Reading; 5 Amyotrophic Lateral Sclerosis and Other TDP-43 Proteinopathies; TDP-43 Biology; Amyotrophic Lateral Sclerosis; ALS-TDP-43; ALS-SOD1; ALS-FUS; ALS-C9ORF72; Mechanisms Dysregulated; Nucleocytoplasmic Transport; Proteostasis Clearance.
[NT 15003449]:	Molecular Mechanism of Prion PropagationThe Cellular Prion Protein: Structure and Proteolytic Processing; Physiological Function of PrPC; Mechanisms of PrPSc Toxicity: The N-Terminal Domain of PrPC Possess a Toxic Effector Activity; Human Prion Diseases; Animal Prion Diseases; Prion Strains and Species Barriers; Methods for Propagation and Detection of Prions; Therapeutic Approaches; PrPC and the Alzheimer's AÝ Peptide; Prion-like Propagation of Misfolded Proteins in Other Neurodegenerative Diseases; Concluding Remarks; References.
Subject:	Nervous system - Degeneration -
Online resource:	https://www.sciencedirect.com/science/book/9780128113042
ISBN:	9780128113059

The molecular and cellular basis of neurodegenerative diseases : = underlying mechanisms /
The molecular and cellular basis of neurodegenerative diseases :underlying mechanisms /edited by Michael S. Wolfe. - 1 online resource

Includes bibliographical references and index.

Front Cover; The Molecular and Cellular Basis of Neurodegenerative Diseases; Copyright Page; Dedication; Contents; List of Contributors; Preface; 1 Solving the Puzzle of Neurodegeneration; Introduction: The General Problem of Neurodegeneration; Epidemiology and Clinical Presentation; Molecular Pathology; Genetics; Molecular Clues to Mechanisms of Pathogenesis; Common Themes and Controversies in Neurodegeneration; Animal Models; Prospects for Therapeutics; Conclusions and Perspective; References; 2 Prion Diseases; Introduction and Historical Perspective.

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer's, Parkinson's, frontotemporal dementia, ALS, Huntington's, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field.

ISBN: 9780128113059Subjects--Topical Terms:

656081
Nervous system
--DegenerationIndex Terms--Genre/Form:

542853
Electronic books.

LC Class. No.: RC394.D35

Dewey Class. No.: 616.80442

The molecular and cellular basis of neurodegenerative diseases : = underlying mechanisms /
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245 0 4 $a The molecular and cellular basis of neurodegenerative diseases : $b underlying mechanisms / $c edited by Michael S. Wolfe.
264 1 $a London : $b Academic Press is an imprint of Elsevier, $c [2018]
264 4 $c ©2018
300 $a 1 online resource
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504 $a Includes bibliographical references and index.
505 0 $a Front Cover; The Molecular and Cellular Basis of Neurodegenerative Diseases; Copyright Page; Dedication; Contents; List of Contributors; Preface; 1 Solving the Puzzle of Neurodegeneration; Introduction: The General Problem of Neurodegeneration; Epidemiology and Clinical Presentation; Molecular Pathology; Genetics; Molecular Clues to Mechanisms of Pathogenesis; Common Themes and Controversies in Neurodegeneration; Animal Models; Prospects for Therapeutics; Conclusions and Perspective; References; 2 Prion Diseases; Introduction and Historical Perspective.
505 0 $a 3 Alzheimer's Disease: Toward a Quantitative Biological Approach in Describing its Natural History and Underlying MechanismsQuantitative Approach to Basic AD Demographics; Change Over Time: (i) Biogenesis, Production, and Turnover of AÝ; Change Over Time: (ii) The Accumulation, Spread, Propagation of AÝ; Change Over Time: (iii) The Growth and Accumulation of Plaque Cores; Change Over Time: (iv) Brain Atrophy; Change Over Time: (v) Cognition; Clearance Mechanisms and Impaired Phagocytosis; Calculating Polygenic Risk Scores.
505 0 $a Mitochondrial Energy ProductionRNA Metabolism; Axonal Dysfunction; Excitotoxicity; Oxidative Stress; Neuroinflammation; Other TDP-43 Proteinopathies; Frontotemporal Dementia; TDP-43 in Alzheimer's Disease and Parkinsonian Syndromes; Inclusion Body Myositis; Conclusions; References; 6 Parkinson's Disease and Other Synucleinopathies; Introduction: The Pathology of Parkinson's Disease; Protein Deposition; Aggregation of Ü-Synuclein in PD; The Broader Set of Synucleinopathies; Changes in Cellularity; Neuronal Loss; Reactive Gliosis; Genes Associated with Synucleinopathies.
505 0 $a Disease-Modifying Strategies: Models of AÝ Accumulation in Alzheimer's Disease-Implications for AÝ Amyloid-Targeting TherapiesReferences; 4 Neurodegeneration and the Ordered Assembly of Tau; Introduction; Tau Isoforms; Tau Aggregation; Genetics of MAPT; Propagation of Tau Aggregates; Strains of Aggregated Tau; Acknowledgments; References; Further Reading; 5 Amyotrophic Lateral Sclerosis and Other TDP-43 Proteinopathies; TDP-43 Biology; Amyotrophic Lateral Sclerosis; ALS-TDP-43; ALS-SOD1; ALS-FUS; ALS-C9ORF72; Mechanisms Dysregulated; Nucleocytoplasmic Transport; Proteostasis Clearance.
505 0 $a Molecular Mechanism of Prion PropagationThe Cellular Prion Protein: Structure and Proteolytic Processing; Physiological Function of PrPC; Mechanisms of PrPSc Toxicity: The N-Terminal Domain of PrPC Possess a Toxic Effector Activity; Human Prion Diseases; Animal Prion Diseases; Prion Strains and Species Barriers; Methods for Propagation and Detection of Prions; Therapeutic Approaches; PrPC and the Alzheimer's AÝ Peptide; Prion-like Propagation of Misfolded Proteins in Other Neurodegenerative Diseases; Concluding Remarks; References.
520 $a The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer's, Parkinson's, frontotemporal dementia, ALS, Huntington's, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field.
650 0 $a Nervous system $x Degeneration $x Molecular aspects. $3 656081
655 4 $a Electronic books. $2 lcsh $3 542853
700 1 $a Wolfe, Michael S., $e editor. $3 3399034
856 4 0 $u https://www.sciencedirect.com/science/book/9780128113042