東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Cognitive Correlates of Anterolatera...

Yeung, Lok-Kin.

Linked to FindBook

Google Book

Amazon

博客來

Cognitive Correlates of Anterolateral Entorhinal Cortex Volume Differences in Older Adults.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Cognitive Correlates of Anterolateral Entorhinal Cortex Volume Differences in Older Adults./
Author:	Yeung, Lok-Kin.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2017,
Description:	190 p.
Notes:	Source: Dissertation Abstracts International, Volume: 79-04(E), Section: B.
Contained By:	Dissertation Abstracts International79-04B(E).
Subject:	Cognitive psychology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10605585
ISBN:	9780355531121

Cognitive Correlates of Anterolateral Entorhinal Cortex Volume Differences in Older Adults.
Yeung, Lok-Kin.

Cognitive Correlates of Anterolateral Entorhinal Cortex Volume Differences in Older Adults. - Ann Arbor : ProQuest Dissertations & Theses, 2017 - 190 p.

Source: Dissertation Abstracts International, Volume: 79-04(E), Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2017.

Alzheimer's disease pathology first appears in the medial temporal lobe (MTL): in particular, in the anterolateral region of the entorhinal cortex (alERC). However, the scientific community has only recently begun to appreciate the importance of the subdivision of the human entorhinal cortex, and as such, our understanding of the alERC's cognitive roles and how it fits into models of MTL function remains limited. In this dissertation, I describe a series of studies inspired by findings from the animal literature, which shed light on the cognitive functions supported by the alERC. Using structural volumetry, I quantified the volumes of the alERC and other MTL regions in a group of ostensibly healthy older adults with varying degrees of cognitive decline. I compared participants' structural differences to their performance on behavioral tasks that we hypothesized represented cognitive functions supported by the alERC. Specifically, I investigated how alERC structural differences were related to performance on the Montreal Cognitive Assessment (MoCA), a standard neuropsychological assessment used in the diagnosis of AD (Chapter 2), as well as eyetracking-based behavioral tasks assessing intra-item configural processing (Chapter 3) and object-in-place memory (Chapter 4), cognitive functions which the rodent literature suggest are supported by the alERC. I found that participants who scored below the MoCA threshold score (indicating possible AD) had smaller alERC volumes (Chapter 2), demonstrating that alERC volume is related to cognitive decline. Further, intra-item configural processing -- regardless of an object's novelty -- was strongly predicted by alERC volume, but not by the volume of any other MTL subregion (Chapter 3). Finally, alERC (and parahippocampal cortex) volume was also related to object-in-place memory for items in everyday scenes, but no such relationship was found for object-trace memory (Chapter 4). Together, these studies suggest that the alERC may support aspects of the spatial processing of objects, advancing our understanding of the cognitive correlates of the alERC. More pragmatically, the alERC-specific tasks I developed may prove useful in early screening for AD and evaluating its progression.

ISBN: 9780355531121Subjects--Topical Terms:

523881
Cognitive psychology.

Cognitive Correlates of Anterolateral Entorhinal Cortex Volume Differences in Older Adults.
LDR:03249nmm a2200313 4500 001 2165709
005 20181129125308.5
008 190424s2017 ||||||||||||||||| ||eng d
020 $a 9780355531121
035 $a (MiAaPQ)AAI10605585
035 $a (MiAaPQ)toronto:15930
035 $a AAI10605585
040 $a MiAaPQ $c MiAaPQ
100 1 $a Yeung, Lok-Kin. $3 3353794
245 1 0 $a Cognitive Correlates of Anterolateral Entorhinal Cortex Volume Differences in Older Adults.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2017
300 $a 190 p.
500 $a Source: Dissertation Abstracts International, Volume: 79-04(E), Section: B.
500 $a Adviser: Morgan D. Barense.
502 $a Thesis (Ph.D.)--University of Toronto (Canada), 2017.
520 $a Alzheimer's disease pathology first appears in the medial temporal lobe (MTL): in particular, in the anterolateral region of the entorhinal cortex (alERC). However, the scientific community has only recently begun to appreciate the importance of the subdivision of the human entorhinal cortex, and as such, our understanding of the alERC's cognitive roles and how it fits into models of MTL function remains limited. In this dissertation, I describe a series of studies inspired by findings from the animal literature, which shed light on the cognitive functions supported by the alERC. Using structural volumetry, I quantified the volumes of the alERC and other MTL regions in a group of ostensibly healthy older adults with varying degrees of cognitive decline. I compared participants' structural differences to their performance on behavioral tasks that we hypothesized represented cognitive functions supported by the alERC. Specifically, I investigated how alERC structural differences were related to performance on the Montreal Cognitive Assessment (MoCA), a standard neuropsychological assessment used in the diagnosis of AD (Chapter 2), as well as eyetracking-based behavioral tasks assessing intra-item configural processing (Chapter 3) and object-in-place memory (Chapter 4), cognitive functions which the rodent literature suggest are supported by the alERC. I found that participants who scored below the MoCA threshold score (indicating possible AD) had smaller alERC volumes (Chapter 2), demonstrating that alERC volume is related to cognitive decline. Further, intra-item configural processing -- regardless of an object's novelty -- was strongly predicted by alERC volume, but not by the volume of any other MTL subregion (Chapter 3). Finally, alERC (and parahippocampal cortex) volume was also related to object-in-place memory for items in everyday scenes, but no such relationship was found for object-trace memory (Chapter 4). Together, these studies suggest that the alERC may support aspects of the spatial processing of objects, advancing our understanding of the cognitive correlates of the alERC. More pragmatically, the alERC-specific tasks I developed may prove useful in early screening for AD and evaluating its progression.
590 $a School code: 0779.
650 4 $a Cognitive psychology. $3 523881
650 4 $a Neurosciences. $3 588700
650 4 $a Medical imaging. $3 3172799
690 $a 0633
690 $a 0317
690 $a 0574
710 2 $a University of Toronto (Canada). $b Psychology. $3 2103544
773 0 $t Dissertation Abstracts International $g 79-04B(E).
790 $a 0779
791 $a Ph.D.
792 $a 2017
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10605585