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Improving the Understanding of Diffe...

Ghedini, Caren Paludo.

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Improving the Understanding of Different Diets on the Concentration and Metabolism of the Mammalian Lignan Enterolactone in Dairy Cattle.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Improving the Understanding of Different Diets on the Concentration and Metabolism of the Mammalian Lignan Enterolactone in Dairy Cattle./
作者:	Ghedini, Caren Paludo.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2017,
面頁冊數:	127 p.
附註:	Source: Dissertation Abstracts International, Volume: 79-07(E), Section: B.
Contained By:	Dissertation Abstracts International79-07B(E).
標題:	Animal sciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10687298
ISBN:	9780355627053

Improving the Understanding of Different Diets on the Concentration and Metabolism of the Mammalian Lignan Enterolactone in Dairy Cattle.
Ghedini, Caren Paludo.

Improving the Understanding of Different Diets on the Concentration and Metabolism of the Mammalian Lignan Enterolactone in Dairy Cattle. - Ann Arbor : ProQuest Dissertations & Theses, 2017 - 127 p.

Source: Dissertation Abstracts International, Volume: 79-07(E), Section: B.

Thesis (Ph.D.)--University of New Hampshire, 2017.

Flaxseed (Linum usitatissimum) is the richest source of the plant lignan secoisolariciresinol diglucoside (SDG), which is precursor for the synthesis of the mammalian lignans enterolactone (EL) and enterodiol (ED) by the gastrointestinal microbes in mammals. There is a great deal of interest in promoting increased intakes of lignans in humans' diet due to their potential health benefits, especially in the prevention of cardiovascular diseases, hypercholesterolaemia, breast and prostate cancers, and osteoporosis. Consumption of milk and dairy products enriched in EL could be an excellent strategy to increase the intake of lignans by humans. The first (Chapter II) and second (Chapter III) studies presented in this dissertation aimed to evaluate strategies to improve the concentration of EL in milk of dairy cows.

ISBN: 9780355627053Subjects--Topical Terms:

3174829
Animal sciences.

Improving the Understanding of Different Diets on the Concentration and Metabolism of the Mammalian Lignan Enterolactone in Dairy Cattle.
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245 1 0 $a Improving the Understanding of Different Diets on the Concentration and Metabolism of the Mammalian Lignan Enterolactone in Dairy Cattle.
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300 $a 127 p.
500 $a Source: Dissertation Abstracts International, Volume: 79-07(E), Section: B.
500 $a Adviser: Andre Fonseca Brito.
502 $a Thesis (Ph.D.)--University of New Hampshire, 2017.
520 $a Flaxseed (Linum usitatissimum) is the richest source of the plant lignan secoisolariciresinol diglucoside (SDG), which is precursor for the synthesis of the mammalian lignans enterolactone (EL) and enterodiol (ED) by the gastrointestinal microbes in mammals. There is a great deal of interest in promoting increased intakes of lignans in humans' diet due to their potential health benefits, especially in the prevention of cardiovascular diseases, hypercholesterolaemia, breast and prostate cancers, and osteoporosis. Consumption of milk and dairy products enriched in EL could be an excellent strategy to increase the intake of lignans by humans. The first (Chapter II) and second (Chapter III) studies presented in this dissertation aimed to evaluate strategies to improve the concentration of EL in milk of dairy cows.
520 $a In Chapter II, we evaluated the effects of replacing ground corn (GRC) with incremental amounts of liquid molasses (LM) on production, milk composition (fat, true protein, lactose, EL, urea N, fatty acids), plasma concentrations of antioxidant enzymes and urea N, and apparent total-tract digestibility of nutrients in Jersey cows fed FM. Sixteen multiparous organically-certified Jersey cows averaging (means +/- standard deviation) 99 +/- 41 d in milk and 462 +/- 38 kg of body weight were randomly assigned to treatment sequences in a replicated 4 x 4 Latin square design with 14 d for diet adaptation and 7 d for data and sample collection. Diets were fed as total mixed rations and consisted (dry matter basis) of 52% grass-legume baleage, 8% grass hay, 8.5% soyhulls, 2.5% roasted soybean, and 15% FM. Ground corn was totally replaced by increasing amounts of LM at 0, 4, 8, or 12% of the diet dry matter. Orthogonal polynomials were used to test linear, quadratic, and cubic effects in response to LM supplementation using the MIXED procedure of SAS.
520 $a In Chapter III was evaluated the effects of feeding flaxseed oil or sucrose alone or in combination on production, milk composition (fat, true protein, lactose, EL, urea N) plasma concentrations of thiobarbituric acid reactive substances (TBARS) and urea N, and apparent total-tract digestibility of nutrients in Holstein cows fed FM. Sixteen multiparous (4 ruminally-cannulated) Holstein cows averaging 94 +/- 37.6 d in milk and 680 +/- 79.1 kg of BW at the beginning of the study were used. Cows were randomly assigned to treatment sequences in a 4 replicated 4 x 4 Latin square design. Each experimental period lasted 25 d with 18 d for diet adaptation and 7 d for data and sample collection. Treatments were fed (dry matter basis) as total-mixed rations consisting of a 60:40 forage-to-concentrate ratio and included: a negative control diet (-CTRL; 8% SBM plus 23% ground corn); 15% FM +10.7% ground corn + 5% sucrose (SUCR); 15% FM + 15.4% ground corn + 3% flaxseed oil (OIL); and 15% FM +10.2% ground corn + 5% sucrose + 3% FO (COMBO).
520 $a A second aim of this dissertation (Chapter IV) was to determine the pharmacokinetics of EL in newborn dairy calves fed milk replacer (MR) or EL-enriched milk. In newborn calves, suckling stimulates the reflex closure of the esophageal groove so that milk or milk replacer bypass the reticulo-rumen down to the abomasum. Thus, calves may be used as a model to make inferences about the pharmacokinetics of EL in simple-stomach mammals including humans. The objective of this study was to determine the pharmacokinetics of EL from MR or EL-enriched milk consumed by newborn Holstein calves. Twenty Holsteins calves (n = 10 males and 10 females) were used from birth to d 7 of life. The 10 calves born from multiparous cows received 4 L of colostrum using nipple bottles. Whereas, the 10 calves born from primiparous cows were fed 4 L of stored colostrum from multiparous cows when available or colostrum replacer. On d 5 of life, calves were administered 2 L of milk replacer (n = 10; Low-EL treatment: 123 nmol/L EL) or 2 L of EL-enriched milk (n = 10; High-EL treatment: 481 nmol/L EL) during the morning feeding (0700 h). Blood samples were taken from the jugular vein before (0 h) and at 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8, 10, 12, 24, and 48 h after oral administration of treatments. (Abstract shortened by ProQuest.).
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