語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Endogenous retrovirus evolution in m...
~
Zhuo, Xiaoyu.
FindBook
Google Book
Amazon
博客來
Endogenous retrovirus evolution in mammalian genomes.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Endogenous retrovirus evolution in mammalian genomes./
作者:
Zhuo, Xiaoyu.
出版者:
Ann Arbor : ProQuest Dissertations & Theses, : 2017,
面頁冊數:
76 p.
附註:
Source: Dissertation Abstracts International, Volume: 78-10(E), Section: B.
Contained By:
Dissertation Abstracts International78-10B(E).
標題:
Genetics. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10264329
ISBN:
9781369775174
Endogenous retrovirus evolution in mammalian genomes.
Zhuo, Xiaoyu.
Endogenous retrovirus evolution in mammalian genomes.
- Ann Arbor : ProQuest Dissertations & Theses, 2017 - 76 p.
Source: Dissertation Abstracts International, Volume: 78-10(E), Section: B.
Thesis (Ph.D.)--The University of Utah, 2017.
Endogenous retroviruses (ERVs), derived from exogenous retroviruses (XRVs), comprise about 5 to 10 % of most mammalian genomes. We can study retroviral infection which originated millions years ago and understand long term evolution of infectious viruses by working on ERVs.
ISBN: 9781369775174Subjects--Topical Terms:
530508
Genetics.
Endogenous retrovirus evolution in mammalian genomes.
LDR
:03243nmm a2200349 4500
001
2156686
005
20180517121918.5
008
190424s2017 ||||||||||||||||| ||eng d
020
$a
9781369775174
035
$a
(MiAaPQ)AAI10264329
035
$a
(MiAaPQ)utah:13770
035
$a
AAI10264329
040
$a
MiAaPQ
$c
MiAaPQ
100
1
$a
Zhuo, Xiaoyu.
$3
3344449
245
1 0
$a
Endogenous retrovirus evolution in mammalian genomes.
260
1
$a
Ann Arbor :
$b
ProQuest Dissertations & Theses,
$c
2017
300
$a
76 p.
500
$a
Source: Dissertation Abstracts International, Volume: 78-10(E), Section: B.
500
$a
Adviser: Cedric Feschotte.
502
$a
Thesis (Ph.D.)--The University of Utah, 2017.
520
$a
Endogenous retroviruses (ERVs), derived from exogenous retroviruses (XRVs), comprise about 5 to 10 % of most mammalian genomes. We can study retroviral infection which originated millions years ago and understand long term evolution of infectious viruses by working on ERVs.
520
$a
At the same time, it has been suggested that multiple, new emerging viruses that infect human populations have been come from different bat species, and bats have become recognized as the reservoir of zoonotic viruses. However, we know little about retroviruses in bats. Here, we mined ERVs in the little brown bat genome, and found that the overall ERV amount in the little brown bat is comparable to other mammals. However, we still find hundreds of lineage-specific ERVs in the little brown bat genome.
520
$a
With identified bat ERVs, we subsequently investigated if there is any related retroviral cross-species transmission and independent endogenization. Using sequence homologous method to search bat ERV sequences against 107 available mammalian genomes, we found highly similar sequences in cat, tiger, and pangolin genomes in addition to related bat genomes. We found the ERV sequence is patchy distributed among mammalian lineages, and their high sequence similarity is incongruent with their host divergence. We also narrowed down the ERV insertion time to 10 to 20 million years ago. To understand how they evolved in different lineages, we investigated their evolution after integration in both bat and cat genomes. In the cat genome, the ERV lost its envelope domain and transformed to intracellular retrotransposon. While in the bat genome, multiple related infectious viruses became endogenized, and, at least in one lineage, the infectious capability has been maintained.
520
$a
Finally, I developed a computational pipeline and statistical framework which allows our method to be applied to the ERV population of virtually any species. When applied to 53 available vertebrate genomes, the approach identified ERVs previously known to have spread by reinfection in humans, mouse, and pig as well as additional ERV families carrying signature of recent infections in these and other species, including nonhuman primates, revealing their potential for zoonotic transmission.
590
$a
School code: 0240.
650
4
$a
Genetics.
$3
530508
650
4
$a
Virology.
$3
642304
650
4
$a
Evolution & development.
$3
3172418
690
$a
0369
690
$a
0720
690
$a
0412
710
2
$a
The University of Utah.
$b
Human Genetics.
$3
3192584
773
0
$t
Dissertation Abstracts International
$g
78-10B(E).
790
$a
0240
791
$a
Ph.D.
792
$a
2017
793
$a
English
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10264329
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9356233
電子資源
11.線上閱覽_V
電子書
EB
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入