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Pharmacokinetic and Pharmacodynamic ...

Sharma, Ankur.

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Pharmacokinetic and Pharmacodynamic Characterization of Sheta2, A Novel Orally Bioavailable Anti-Cancer Drug Towards Clinical Translation.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Pharmacokinetic and Pharmacodynamic Characterization of Sheta2, A Novel Orally Bioavailable Anti-Cancer Drug Towards Clinical Translation./
Author:	Sharma, Ankur.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2017,
Description:	190 p.
Notes:	Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.
Contained By:	Dissertation Abstracts International78-09B(E).
Subject:	Pharmaceutical sciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10257485
ISBN:	9781369714371

Pharmacokinetic and Pharmacodynamic Characterization of Sheta2, A Novel Orally Bioavailable Anti-Cancer Drug Towards Clinical Translation.
Sharma, Ankur.

Pharmacokinetic and Pharmacodynamic Characterization of Sheta2, A Novel Orally Bioavailable Anti-Cancer Drug Towards Clinical Translation. - Ann Arbor : ProQuest Dissertations & Theses, 2017 - 190 p.

Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.

Thesis (Ph.D.)--The University of Oklahoma Health Sciences Center, 2017.

SHetA2 is a flexible heteroarotinoid (Flex-Het), which was selected as a lead from a series of Flex-Het based on potent induction of apoptosis in cancer cells. With the promising preclinical safety and efficacy profiles, SHetA2 is now moved forward for clinical development. Well-designed experiments in preclinical animal models and utilization of physiologically, mechanism-based pharmacokinetic and pharmacodynamic (PBPK/PD) models can provide better quantitation and prediction of the disposition and dynamics of SHetA2. The main goal of this thesis was to develop PBPK/PD models for SHetA2 that not only can provide improved understanding of SHetA2 PK/PD but also can assist more rationale design of Phase 0/I clinical trials of SHetA2, thereby decreasing risk of failure at the clinical development stage and making the clinical trial cost effective. (Abstract shortened by ProQuest.).

ISBN: 9781369714371Subjects--Topical Terms:

3173021
Pharmaceutical sciences.

Pharmacokinetic and Pharmacodynamic Characterization of Sheta2, A Novel Orally Bioavailable Anti-Cancer Drug Towards Clinical Translation.
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500 $a Adviser: Sukyung Woo.
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