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Polymeric Stimuli-Sensitive Self-Ass...

Liu, Fei.

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Polymeric Stimuli-Sensitive Self-Assembled Micro- and Nanoparticles for Controlled Drug Delivery.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Polymeric Stimuli-Sensitive Self-Assembled Micro- and Nanoparticles for Controlled Drug Delivery./
作者:	Liu, Fei.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2017,
面頁冊數:	160 p.
附註:	Source: Dissertation Abstracts International, Volume: 78-10(E), Section: B.
Contained By:	Dissertation Abstracts International78-10B(E).
標題:	Polymer chemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10259661
ISBN:	9781369826173

Polymeric Stimuli-Sensitive Self-Assembled Micro- and Nanoparticles for Controlled Drug Delivery.
Liu, Fei.

Polymeric Stimuli-Sensitive Self-Assembled Micro- and Nanoparticles for Controlled Drug Delivery. - Ann Arbor : ProQuest Dissertations & Theses, 2017 - 160 p.

Source: Dissertation Abstracts International, Volume: 78-10(E), Section: B.

Thesis (Ph.D.)--The University of Alabama at Birmingham, 2017.

The research presented in this thesis is focused on the design and development of stimuli-responsive polymeric particles for drug delivery, including tannic acid-based layer-by-layer capsules with pH- and ionic strength-dependent permeability as well as size- and structure-tunable poly-(N-vinylcaprolactam)-based temperature-responsive polymersomes and micelles.

ISBN: 9781369826173Subjects--Topical Terms:

3173488
Polymer chemistry.

Polymeric Stimuli-Sensitive Self-Assembled Micro- and Nanoparticles for Controlled Drug Delivery.
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500 $a Source: Dissertation Abstracts International, Volume: 78-10(E), Section: B.
500 $a Adviser: Eugenia Kharlampieva.
502 $a Thesis (Ph.D.)--The University of Alabama at Birmingham, 2017.
520 $a The research presented in this thesis is focused on the design and development of stimuli-responsive polymeric particles for drug delivery, including tannic acid-based layer-by-layer capsules with pH- and ionic strength-dependent permeability as well as size- and structure-tunable poly-(N-vinylcaprolactam)-based temperature-responsive polymersomes and micelles.
520 $a Polymer-based particles play essential roles in controlled drug delivery due to their tunable sizes and nanostructures, and can be further advanced through functionalization, allowing pH-, ionic strength- and temperature-sensitivities to alter the therapeutics' pharmacokinetics and bio-distribution. Two typical pathways for engineering polymeric drug delivery vehicles are introduced in this thesis, layer-by-layer self-assembly at inter-faces and self-assembly from block copolymers solutions.
520 $a In Chapter two, tannic acid/poly(N-vinyl pyrrolidone) (TA/PVPON) hydrogen bonded films and capsules were fabricated and loaded with the hydrophobic anticancer drug doxorubicin (DOX). The pH- and ionic strength-dependent ionization degree of TA allows precise control of the film thickness as well as the permeability after being self-assembled with PVPON by hydrogen bonding. The hydrophobic therapeutic doxorubicin (DOX) can be loaded into the novel TA/PVPON capsules with high loading capacity at 1.41x10-3 ng of DOX per capsule at both pH 7.4 and 5 for long term storage.
520 $a In Chapter three, novel temperature-sensitive polymersomes from poly(-N-vinylcaprolactam) n-poly(dimethylsiloxane)65-poly(-N-vinylcaprolactam) n (PVCLn-PDMS65-PVCLn) triblock copolymers were investigated. The chain length of the temper-ature-responsive component PVCL was accurately controlled by using RAFT controlled polymerization and the polymersome structure was modulated by adjusting the hydro-philic content ratio. Reversible temperature-sensitive size and permeability changes of fabricated polymersomes were observed from 25 to 55 °C. Hydrophilic doxorubicin hy-drochloride (DOX HCl) can be loaded into synthesized polymersomes with precisely controlled temperature-dependent release. Further, Dox-loaded polymersomes exhibit both concentration- and time-dependent cytotoxicity for human alveolar adenocarcinoma cells.
520 $a In Chapter four, novel duel temperature-responsive micelles from poly(3-methyl-N-vinylcaprolactam-co-vinylcaprolactam)-b-poly(vinyl caprolactam-co-vinyl pyrrolidone) diblock copolymer were studied. Novel monomer 3-methyl-N-vinylcaprolactam was synthesized and utilized to form block copolymers in order to achieve structural ho-mogeneity. The synthesized amphiphilic block copolymer can self-assembly into micelles at room temperature with two LCSTs. The first LCST was found to be between 19 to 27 °C and can be used to load the hydrophobic drug DOX and form micelles. The second LCST is controlled between 41 and 42 °C caused micelles aggregation and therefore can be useful in achieving targeting functionality for pathological tissues that have elevated temperatures.
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