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Cell-Type Specific Actions of Inflam...

An, Ying.

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Cell-Type Specific Actions of Inflammatory Mediators in the CNS.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Cell-Type Specific Actions of Inflammatory Mediators in the CNS./
Author:	An, Ying.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2016,
Description:	172 p.
Notes:	Source: Dissertation Abstracts International, Volume: 78-02(E), Section: B.
Contained By:	Dissertation Abstracts International78-02B(E).
Subject:	Neurobiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10169010
ISBN:	9781369232325

Cell-Type Specific Actions of Inflammatory Mediators in the CNS.
An, Ying.

Cell-Type Specific Actions of Inflammatory Mediators in the CNS. - Ann Arbor : ProQuest Dissertations & Theses, 2016 - 172 p.

Source: Dissertation Abstracts International, Volume: 78-02(E), Section: B.

Thesis (Ph.D.)--The Ohio State University, 2016.

Neuroinflammation is a critical feature associated with many neurological diseases. Two potent pro-inflammatory mediators, interleukin-1 (IL-1) and cyclooxygenase-2 (COX-2), are induced and have diverse activities in inflammatory processes and disease progression. One of the mechanisms underlying the multifunctional roles of IL-1 and COX-2 is that they may exert distinct effects in different CNS cell types. We investigated the direct actions of IL-1 on brain endothelial cells, astrocytes, and microglia in cell cultures. We studied the cellular actions of inducible COX-2 in neurons and non-neuronal cells by using two Cox-2 conditional knockout mouse strains. In the first study, we demonstrated that IL-1 exerts distinct cell type-specific action in CNS cells and activates cellular specific signaling pathways. In the second study, we demonstrated that COX-2 induced in neurons may have neurotoxic effects whereas COX-2 induced in non-neuronal cells may have neuroprotective activities. We further uncovered the possible prostaglandin products that may mediate the opposing effects of COX-2 in each of the two cell types. These results together suggest that IL-1 or COX-2 mediated neuroinflammation is the result of the summation of multiple responses from different cell types in the CNS to IL-1 or COX-2.

ISBN: 9781369232325Subjects--Topical Terms:

588707
Neurobiology.

Cell-Type Specific Actions of Inflammatory Mediators in the CNS.
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