東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Dysbiosis and Host Health: Uncoverin...

Galley, Jeffrey David.

Linked to FindBook

Google Book

Amazon

博客來

Dysbiosis and Host Health: Uncovering the Connection between the Microbiota and Disease.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Dysbiosis and Host Health: Uncovering the Connection between the Microbiota and Disease./
Author:	Galley, Jeffrey David.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2015,
Description:	236 p.
Notes:	Source: Dissertation Abstracts International, Volume: 76-11(E), Section: B.
Contained By:	Dissertation Abstracts International76-11B(E).
Subject:	Microbiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3710164
ISBN:	9781321860191

Dysbiosis and Host Health: Uncovering the Connection between the Microbiota and Disease.
Galley, Jeffrey David.

Dysbiosis and Host Health: Uncovering the Connection between the Microbiota and Disease. - Ann Arbor : ProQuest Dissertations & Theses, 2015 - 236 p.

Source: Dissertation Abstracts International, Volume: 76-11(E), Section: B.

Thesis (Ph.D.)--The Ohio State University, 2015.

The human gastrointestinal tract is heavily colonized by millions of bacteria, termed the microbiota, which is closely involved in host metabolic and immunological processes. This beneficial relationship is dependent upon the community structure of the microbiota, as defined by the relative proportions and diversity of the groups within the community. External or internal factors can impact these population abundances, which can have deleterious effects upon host health. This condition, termed dysbiosis, has been associated with inflammatory bowel disease as well as obesity. We developed this study to ascertain factors that influence mammalian hosts to acquire dysbiotic microbiota, and to associate dysbiosis with changes in host health.

ISBN: 9781321860191Subjects--Topical Terms:

536250
Microbiology.

Dysbiosis and Host Health: Uncovering the Connection between the Microbiota and Disease.
LDR:04955nmm a2200337 4500 001 2127456
005 20171220071115.5
008 180830s2015 ||||||||||||||||| ||eng d
020 $a 9781321860191
035 $a (MiAaPQ)AAI3710164
035 $a AAI3710164
040 $a MiAaPQ $c MiAaPQ
100 1 $a Galley, Jeffrey David. $3 3289597
245 1 0 $a Dysbiosis and Host Health: Uncovering the Connection between the Microbiota and Disease.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2015
300 $a 236 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-11(E), Section: B.
500 $a Adviser: Michael Bailey.
502 $a Thesis (Ph.D.)--The Ohio State University, 2015.
520 $a The human gastrointestinal tract is heavily colonized by millions of bacteria, termed the microbiota, which is closely involved in host metabolic and immunological processes. This beneficial relationship is dependent upon the community structure of the microbiota, as defined by the relative proportions and diversity of the groups within the community. External or internal factors can impact these population abundances, which can have deleterious effects upon host health. This condition, termed dysbiosis, has been associated with inflammatory bowel disease as well as obesity. We developed this study to ascertain factors that influence mammalian hosts to acquire dysbiotic microbiota, and to associate dysbiosis with changes in host health.
520 $a Psychological stressor exposure is a primary correlate of symptomatic episodes (e.g., pain, bleeding) in patients with inflammatory bowel disease, though it is not understood how this occurs. Previous studies have shown that exposing mammals to stress can affect the microbiota which are associated with GI mucosal immunity, but the changes have been not been well-defined, particularly in mice. Thus, mice were exposed to a long-term stressor known as restraint in order to evaluate how stress exposure affects the murine gastrointestinal microbiota. In addition, mice were subjected to a social stressor, social disruption, in order to determine if the type and duration of the stressor affects microbiota community structure differently. Colonic mucosal and luminal contents were collected and 16S rRNA sequences were analyzed.
520 $a Mice exposed to either restraint or SDR had significant increases in severity of infection by an enteric pathogen, Citrobacter rodentium . iNOS, IL-1beta, CCL2, and TNF-alpha were significantly increased in mice exposed to the stressors, and overall colitic pathology was also increased in the stress-exposed mice. In order to determine if there is an association between stress-induced changes to the microbiota, and stress-induced aggravation of colitic inflammation during pathogen challenge, germ-free mice were given oral gavage of the fecal slurry from stressor-exposed conventional mice, and then challenged with C. rodentium. Mice that received the stress-exposed microbiota had increased pro-inflammatory transcript levels as well as heightened colitic pathology, indicating that stressor-induced changes to the microbiota are associated with changes in gastrointestinal immune function.
520 $a Though these findings make evident that external factors such as psychological stress can disturb healthy microbiota structures, which can then feed deleteriously back upon murine host health, it is not known whether such extrinsic impacts can shift microbiota profiles in human hosts. Host-to-host transmission of microbiota communities is another possible mechanism by which a host might incorporate a dysbiotic profile. Mothers are a primary source of microbes for their offspring in early life, and maternal obesity is a strong antecedent for obesity in later life for the offspring. Thus, we hypothesized that children born to obese mothers will have a unique microbiota structure. Indeed, using UniFrac unweighted distances, children, aged around two years and born to high-income obese mothers clustered separately from children born to high-income non-obese mothers. Clustering was not seen in children born to low-income mothers. These data indicate that both socioeconomic status of the mother, and maternal obesity associate with the community structure of their children. In sum, these combined data of psychological stress within mice and obese microbiota associations between mother and child in humans lend credence to the overarching hypothesis that external factors can significantly impact microbiota community structure, resulting in changes to health-associated microbial groups and disturbing normal host immune or physiological activity. (Abstract shortened by UMI.).
590 $a School code: 0168.
650 4 $a Microbiology. $3 536250
650 4 $a Psychobiology. $3 555678
650 4 $a Immunology. $3 611031
690 $a 0410
690 $a 0349
690 $a 0982
710 2 $a The Ohio State University. $b Oral Biology. $3 3289598
773 0 $t Dissertation Abstracts International $g 76-11B(E).
790 $a 0168
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3710164