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Development of optically based ph se...

Nielsen, Matthew.

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Development of optically based ph sensing hydrogel and controlled nitric oxide release polymer.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Development of optically based ph sensing hydrogel and controlled nitric oxide release polymer./
作者:	Nielsen, Matthew.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2013,
面頁冊數:	140 p.
附註:	Source: Dissertation Abstracts International, Volume: 75-01(E), Section: B.
Contained By:	Dissertation Abstracts International75-01B(E).
標題:	Biomedical engineering. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3595416
ISBN:	9781303409066

Development of optically based ph sensing hydrogel and controlled nitric oxide release polymer.
Nielsen, Matthew.

Development of optically based ph sensing hydrogel and controlled nitric oxide release polymer. - Ann Arbor : ProQuest Dissertations & Theses, 2013 - 140 p.

Source: Dissertation Abstracts International, Volume: 75-01(E), Section: B.

Thesis (Ph.D.)--Michigan Technological University, 2013.

Nitric oxide has the potential to greatly improve intravascular measurements by locally inhibiting thrombus formation and dilating blood vessels. pH, the partial pressure of oxygen, and the partial pressure of carbon dioxide are three arterial blood parameters that are of interest to clinicians in the intensive care unit that can benefit from an intravascular sensor. This work explores fabrication of absorbance and fluorescence based pH sensing chemistry, the sensing chemistries' compatibility with nitric oxide, and a controllable nitric oxide releasing polymer.

ISBN: 9781303409066Subjects--Topical Terms:

535387
Biomedical engineering.

Development of optically based ph sensing hydrogel and controlled nitric oxide release polymer.
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100 1 $a Nielsen, Matthew. $3 3287727
245 1 0 $a Development of optically based ph sensing hydrogel and controlled nitric oxide release polymer.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2013
300 $a 140 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-01(E), Section: B.
500 $a Adviser: Megan C. Frost.
502 $a Thesis (Ph.D.)--Michigan Technological University, 2013.
520 $a Nitric oxide has the potential to greatly improve intravascular measurements by locally inhibiting thrombus formation and dilating blood vessels. pH, the partial pressure of oxygen, and the partial pressure of carbon dioxide are three arterial blood parameters that are of interest to clinicians in the intensive care unit that can benefit from an intravascular sensor. This work explores fabrication of absorbance and fluorescence based pH sensing chemistry, the sensing chemistries' compatibility with nitric oxide, and a controllable nitric oxide releasing polymer.
520 $a The pH sensing chemistries utilized various substrates, dyes, and methods of immobilization. Absorbance sensing chemistries used sol--gels, fumed silica particles, mesoporous silicon oxide, bromocresol purple, phenol red, bromocresol green, physical entrapment, molecular interactions, and covalent linking. Covalently linking the dyes to fumed silica particles and mesoporous silicon oxide eliminated leaching in the absorbance sensing chemistries. The structures of the absorbance dyes investigated were similar and bromocresol green in a sol--gel was tested for compatibility with nitric oxide. Nitric oxide did not interfere with the use of bromocresol green in a pH sensor. Investigated fluorescence sensing chemistries utilized silica optical fibers, poly(allylamine) hydrogel, SNARF--1, molecular interactions, and covalent linking. SNARF--1 covalently linked to a modified poly(allylamine) hydrogel was tested in the presence of nitric oxide and showed no interference from the nitric oxide. Nitric oxide release was controlled through the modulation of a light source that cleaved the bond between the nitric oxide and a sulfur atom in the donor. The nitric oxide donor in this work is S--nitroso--N--acetyl--D--penicillamine which was covalently linked to a silicone rubber made from polydimethylsiloxane. It is shown that the surface flux of nitric oxide released from the polymer films can be increased and decreased by increasing and decreasing the output power of the LED light source. In summary, an optical pH sensing chemistry was developed that eliminated the chronic problem of leaching of the indicator dye and showed no reactivity to nitric oxide released, thereby facilitating the development of a functional, reliable intravascular sensor.
590 $a School code: 0129.
650 4 $a Biomedical engineering. $3 535387
650 4 $a Polymer chemistry. $3 3173488
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710 2 $a Michigan Technological University. $b Biomedical Engineering. $3 3287214
773 0 $t Dissertation Abstracts International $g 75-01B(E).
790 $a 0129
791 $a Ph.D.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3595416