東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Tissue integration and antimicrobial...

Nichols, Scott Philip.

FindBook

Google Book

Amazon

博客來

Tissue integration and antimicrobial effects of surface-derived nitric oxide release.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Tissue integration and antimicrobial effects of surface-derived nitric oxide release./
作者:	Nichols, Scott Philip.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2012,
面頁冊數:	146 p.
附註:	Source: Dissertation Abstracts International, Volume: 74-05(E), Section: B.
Contained By:	Dissertation Abstracts International74-05B(E).
標題:	Analytical chemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3549688
ISBN:	9781267862099

Tissue integration and antimicrobial effects of surface-derived nitric oxide release.
Nichols, Scott Philip.

Tissue integration and antimicrobial effects of surface-derived nitric oxide release. - Ann Arbor : ProQuest Dissertations & Theses, 2012 - 146 p.

Source: Dissertation Abstracts International, Volume: 74-05(E), Section: B.

Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2012.

The analytical performance of glucose sensors is inhibited by the host's foreign body response (FBR) and risk of bacterial infection. To date, no one strategy has circumvented the physiological reactions to implanted materials. Nitric oxide (NO) is an endogenously produced free radical that acts to initiate events in the FBR and fight bacterial infection. Herein, the potential of NO-releasing surfaces to both mitigate the FBR and bacterial invasion is described.

ISBN: 9781267862099Subjects--Topical Terms:

3168300
Analytical chemistry.

Tissue integration and antimicrobial effects of surface-derived nitric oxide release.
LDR:03353nmm a2200349 4500 001 2125638
005 20171113102614.5
008 180830s2012 ||||||||||||||||| ||eng d
020 $a 9781267862099
035 $a (MiAaPQ)AAI3549688
035 $a AAI3549688
040 $a MiAaPQ $c MiAaPQ
100 1 $a Nichols, Scott Philip. $3 3287721
245 1 0 $a Tissue integration and antimicrobial effects of surface-derived nitric oxide release.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2012
300 $a 146 p.
500 $a Source: Dissertation Abstracts International, Volume: 74-05(E), Section: B.
500 $a Adviser: Mark H. Schoenfisch.
502 $a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2012.
520 $a The analytical performance of glucose sensors is inhibited by the host's foreign body response (FBR) and risk of bacterial infection. To date, no one strategy has circumvented the physiological reactions to implanted materials. Nitric oxide (NO) is an endogenously produced free radical that acts to initiate events in the FBR and fight bacterial infection. Herein, the potential of NO-releasing surfaces to both mitigate the FBR and bacterial invasion is described.
520 $a Evaluation of the performance of NO-releasing surfaces to improve glucose sensor performance in vivo was carried out through imparting NO release to microdialysis probes. Perfusion of saturated NO solutions through implanted probes delivered a constant flux of 162 pmol cm-2 s -1 delivering 4.6 mumol cm-2 NO each day. The NO-releasing probes recovered significantly greater concentrations of glucose after 7 d of implantation versus controls. Histological analysis revealed a thinner collagen capsule and decreased inflammation adjacent to NO-releasing probes.
520 $a To investigate the necessary NO-release properties to achieve the observed histological benefits, NO-releasing polyurethane-coated wires were implanted into a porcine model for up to 6 weeks. Polyurethanes were doped with small molecules or nanoparticles to alter the NO release kinetics, fluxes, and total payloads. Materials with a NO-release duration of 14 d and large NO payload (9.3 mumol cm-2) were most effective at decreasing the collagen encapsulation and inflammation adjacent to the implants. Inflammation was only modulated during active NO release from the implant.
520 $a While modulation of the FBR is essential for the development of glucose sensors, infection by bacteria is a constant threat. Biomaterial-associated infections most commonly begin through adhesion to the implanted material. Therefore, evaluation of the anti-adhesive properties of NO-releasing surfaces was undertaken by examining the adhesion of six bacterial strains to a wide range of NO fluxes (0.5-50 pmol cm-2 s-1). An average NO flux between 50 pmol cm-2 s-1 reduced surface coverage of all strains by >80% over 1 h. Further, after incubation of adhered bacteria in bacteriostatic conditions for 24 h, large surface-derived NO payloads (1.7 mumol cm-2) decreased viability of adhered bacteria by ≥85%.
590 $a School code: 0153.
650 4 $a Analytical chemistry. $3 3168300
650 4 $a Biomedical engineering. $3 535387
650 4 $a Biochemistry. $3 518028
650 4 $a Cellular biology. $3 3172791
690 $a 0486
690 $a 0541
690 $a 0487
690 $a 0379
710 2 $a The University of North Carolina at Chapel Hill. $b Chemistry. $3 1021872
773 0 $t Dissertation Abstracts International $g 74-05B(E).
790 $a 0153
791 $a Ph.D.
792 $a 2012
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3549688