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PET/MR Imaging of Hypoxic Atheroscle...

Nie, Xingyu.

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PET/MR Imaging of Hypoxic Atherosclerotic Plaque Using 64Cu-ATSM.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	PET/MR Imaging of Hypoxic Atherosclerotic Plaque Using 64Cu-ATSM./
作者:	Nie, Xingyu.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2017,
面頁冊數:	165 p.
附註:	Source: Dissertation Abstracts International, Volume: 78-08(E), Section: B.
Contained By:	Dissertation Abstracts International78-08B(E).
標題:	Medical imaging. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10262628
ISBN:	9781369681628

PET/MR Imaging of Hypoxic Atherosclerotic Plaque Using 64Cu-ATSM.
Nie, Xingyu.

PET/MR Imaging of Hypoxic Atherosclerotic Plaque Using 64Cu-ATSM. - Ann Arbor : ProQuest Dissertations & Theses, 2017 - 165 p.

Source: Dissertation Abstracts International, Volume: 78-08(E), Section: B.

Thesis (Ph.D.)--Washington University in St. Louis, 2017.

It is important to accurately identify the factors involved in the progression of atherosclerosis because advanced atherosclerotic lesions are prone to rupture, leading to disability or death. Hypoxic areas have been known to be present in human atherosclerotic lesions, and lesion progression is associated with the formation of lipid-loaded macrophages and increased local inflammation which are potential major factors in the formation of vulnerable plaque. This dissertation work represents a comprehensive investigation of non-invasive identification of hypoxic atherosclerotic plaque in animal models and human subjects using the PET hypoxia imaging agent 64Cu-ATSM.

ISBN: 9781369681628Subjects--Topical Terms:

3172799
Medical imaging.

PET/MR Imaging of Hypoxic Atherosclerotic Plaque Using 64Cu-ATSM.
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500 $a Source: Dissertation Abstracts International, Volume: 78-08(E), Section: B.
500 $a Advisers: Pamela K. Woodard; Suzanne Lapi.
502 $a Thesis (Ph.D.)--Washington University in St. Louis, 2017.
520 $a It is important to accurately identify the factors involved in the progression of atherosclerosis because advanced atherosclerotic lesions are prone to rupture, leading to disability or death. Hypoxic areas have been known to be present in human atherosclerotic lesions, and lesion progression is associated with the formation of lipid-loaded macrophages and increased local inflammation which are potential major factors in the formation of vulnerable plaque. This dissertation work represents a comprehensive investigation of non-invasive identification of hypoxic atherosclerotic plaque in animal models and human subjects using the PET hypoxia imaging agent 64Cu-ATSM.
520 $a We first demonstrated the feasibility of 64Cu-ATSM for the identification of hypoxic atherosclerotic plaque and evaluated the relative effects of diet and genetics on hypoxia progression in atherosclerotic plaque in a genetically-altered mouse model. We then fully validated the feasibility of using 64Cu-ATSM to image the extent of hypoxia in a rabbit model with atherosclerotic-like plaque using a simultaneous PET-MR system. We also proceeded with a pilot clinical trial to determine whether 64Cu-ATSM MR/PET scanning is capable of detecting hypoxic carotid atherosclerosis in human subjects.
520 $a In order to improve the 64Cu-ATSM PET image quality, we investigated the Siemens HD (high-definition) PET software and 4 partial volume correction methods to correct for partial volume effects. In addition, we incorporated the attenuation effect of the carotid surface coil into the MR attenuation correction mu-map to correct for photon attention.
520 $a In the long term, this imaging strategy has the potential to help identify patients at risk for cardiovascular events, guide therapy, and add to the understanding of plaque biology in human patients.
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