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I. Nickel-Catalyzed Reductive Coupli...

Rugg Dorn, Stephanie C. M.

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I. Nickel-Catalyzed Reductive Coupling with Michael Acceptors, And, II. Asymmetric Nickel-Catalyzed Reductive Coupling.

Record Type:	Electronic resources : Monograph/item
Title/Author:	I. Nickel-Catalyzed Reductive Coupling with Michael Acceptors, And, II. Asymmetric Nickel-Catalyzed Reductive Coupling./
Author:	Rugg Dorn, Stephanie C. M.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2015,
Description:	219 p.
Notes:	Source: Dissertation Abstracts International, Volume: 77-02(E), Section: B.
Contained By:	Dissertation Abstracts International77-02B(E).
Subject:	Organic chemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3731668
ISBN:	9781339180847

I. Nickel-Catalyzed Reductive Coupling with Michael Acceptors, And, II. Asymmetric Nickel-Catalyzed Reductive Coupling.
Rugg Dorn, Stephanie C. M.

I. Nickel-Catalyzed Reductive Coupling with Michael Acceptors, And, II. Asymmetric Nickel-Catalyzed Reductive Coupling. - Ann Arbor : ProQuest Dissertations & Theses, 2015 - 219 p.

Source: Dissertation Abstracts International, Volume: 77-02(E), Section: B.

Thesis (Ph.D.)--University of Rochester, 2015.

This item is not available from ProQuest Dissertations & Theses.

Carbon-carbon bond formation is critical for the synthesis of biologically active compounds and materials. Cross-electrophile coupling to form carbon-carbon bonds is a relatively new method that enables the scientist to start from commercially available compounds (organo halides), and is an alternative to the traditional transition-metal catalyzed cross-coupling requiring organometallic nucleophiles. This thesis describes the author's work in developing cross-electrophile coupling with Michael acceptors, and developing the previously established cross-coupling reactions to be asymmetric.

ISBN: 9781339180847Subjects--Topical Terms:

523952
Organic chemistry.

I. Nickel-Catalyzed Reductive Coupling with Michael Acceptors, And, II. Asymmetric Nickel-Catalyzed Reductive Coupling.
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245 1 0 $a I. Nickel-Catalyzed Reductive Coupling with Michael Acceptors, And, II. Asymmetric Nickel-Catalyzed Reductive Coupling.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2015
300 $a 219 p.
500 $a Source: Dissertation Abstracts International, Volume: 77-02(E), Section: B.
500 $a Adviser: Daniel J. Weix.
502 $a Thesis (Ph.D.)--University of Rochester, 2015.
506 $a This item is not available from ProQuest Dissertations & Theses.
520 $a Carbon-carbon bond formation is critical for the synthesis of biologically active compounds and materials. Cross-electrophile coupling to form carbon-carbon bonds is a relatively new method that enables the scientist to start from commercially available compounds (organo halides), and is an alternative to the traditional transition-metal catalyzed cross-coupling requiring organometallic nucleophiles. This thesis describes the author's work in developing cross-electrophile coupling with Michael acceptors, and developing the previously established cross-coupling reactions to be asymmetric.
520 $a Chapter 1 begins with an introduction to conjugate addition and other methods to make conjugate addition-type products, including the use of electrochemistry, reductive Heck coupling, and allyl nickel complexes. Mechanistic studies of the established cross-coupling using cyclohexenone, silyl chlorides, and aryl halides is presented. This chapter also details other Michael acceptors, including acyclic enones, alpha,beta-unsaturated aldehydes, beta,beta-disubstituted-alpha,beta-unsaturated carbonyls, and activated alkynes.
520 $a Chapter 2 focuses on conducting cross-electrophile reactions that have been developed in the Weix group with chiral amine ligands. While enantioselectivity (and in some cases, reactivity) remains a challenge, some transition-state models and ligand ideas are presented.
590 $a School code: 0188.
650 4 $a Organic chemistry. $3 523952
650 4 $a Analytical chemistry. $3 3168300
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690 $a 0486
710 2 $a University of Rochester. $b School of Arts and Sciences. $3 2099014
773 0 $t Dissertation Abstracts International $g 77-02B(E).
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791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3731668