東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Gold-Catalyzed Asymmetric Synthesis ...

Uehling, Mycah R.

FindBook

Google Book

Amazon

博客來

Gold-Catalyzed Asymmetric Synthesis of Cyclic Ethers and Copper-Catalyzed Hydrofunctionalization of Alkynes.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Gold-Catalyzed Asymmetric Synthesis of Cyclic Ethers and Copper-Catalyzed Hydrofunctionalization of Alkynes./
作者:	Uehling, Mycah R.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2015,
面頁冊數:	169 p.
附註:	Source: Dissertation Abstracts International, Volume: 76-12(E), Section: B.
Contained By:	Dissertation Abstracts International76-12B(E).
標題:	Organic chemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3718846
ISBN:	9781321988833

Gold-Catalyzed Asymmetric Synthesis of Cyclic Ethers and Copper-Catalyzed Hydrofunctionalization of Alkynes.
Uehling, Mycah R.

Gold-Catalyzed Asymmetric Synthesis of Cyclic Ethers and Copper-Catalyzed Hydrofunctionalization of Alkynes. - Ann Arbor : ProQuest Dissertations & Theses, 2015 - 169 p.

Source: Dissertation Abstracts International, Volume: 76-12(E), Section: B.

Thesis (Ph.D.)--University of Washington, 2015.

Gold-catalyzed cyclization of enantioenriched trisubstituted allenols to form enantioenriched alpha-tetrasubstituted cyclic ethers has been developed. This structural motif can be found in many natural products that have useful biological properties. The cyclization reaction is compatible with multiple functional groups and can be used to prepare enantioenriched furans, pyrans, and chromans all containing an ?-tetrasubstituted stereocenter. The reaction development, scope, and a preliminary mechanistic study are discussed. In addition, a method to synthesize the required enantioenriched trisubstituted allenols based on copper-catalyzed cross coupling of enantioenriched propargylic phosphates and organoboron reagents has been developed. This allows the overall sequence to be practical and convergent.

ISBN: 9781321988833Subjects--Topical Terms:

523952
Organic chemistry.

Gold-Catalyzed Asymmetric Synthesis of Cyclic Ethers and Copper-Catalyzed Hydrofunctionalization of Alkynes.
LDR:02327nmm a2200289 4500 001 2124609
005 20171030113311.5
008 180830s2015 ||||||||||||||||| ||eng d
020 $a 9781321988833
035 $a (MiAaPQ)AAI3718846
035 $a AAI3718846
040 $a MiAaPQ $c MiAaPQ
100 1 $a Uehling, Mycah R. $3 3286613
245 1 0 $a Gold-Catalyzed Asymmetric Synthesis of Cyclic Ethers and Copper-Catalyzed Hydrofunctionalization of Alkynes.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2015
300 $a 169 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-12(E), Section: B.
500 $a Adviser: Gojko Lalic.
502 $a Thesis (Ph.D.)--University of Washington, 2015.
520 $a Gold-catalyzed cyclization of enantioenriched trisubstituted allenols to form enantioenriched alpha-tetrasubstituted cyclic ethers has been developed. This structural motif can be found in many natural products that have useful biological properties. The cyclization reaction is compatible with multiple functional groups and can be used to prepare enantioenriched furans, pyrans, and chromans all containing an ?-tetrasubstituted stereocenter. The reaction development, scope, and a preliminary mechanistic study are discussed. In addition, a method to synthesize the required enantioenriched trisubstituted allenols based on copper-catalyzed cross coupling of enantioenriched propargylic phosphates and organoboron reagents has been developed. This allows the overall sequence to be practical and convergent.
520 $a Copper-catalyzed hydrobromination and hydroalkylation of alkynes have been developed. The reactions are compatible with many functional groups and can be used to prepare functionalized alkenes in high yield and as one regio- and diastereoisomer. The reaction development, scope, and preliminary mechanism studies are discussed for both reactions. The development of copper-catalyzed hydrobromination and hydroalkylation of alkynes demonstrates that copper-catalyzed hydrofunctionalization of alkynes is a general approach to the synthesis of different types of functionalized alkenes.
590 $a School code: 0250.
650 4 $a Organic chemistry. $3 523952
690 $a 0490
710 2 $a University of Washington. $b Chemistry. $3 2093573
773 0 $t Dissertation Abstracts International $g 76-12B(E).
790 $a 0250
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3718846