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Co(II)-Based Metalloradical Catalysi...

Cheng, Qigan.

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Co(II)-Based Metalloradical Catalysis for Asymmetric Radical Cyclopropanation.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Co(II)-Based Metalloradical Catalysis for Asymmetric Radical Cyclopropanation./
Author:	Cheng, Qigan.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2016,
Description:	342 p.
Notes:	Source: Dissertation Abstracts International, Volume: 77-11(E), Section: B.
Contained By:	Dissertation Abstracts International77-11B(E).
Subject:	Organic chemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10112567
ISBN:	9781339757216

Co(II)-Based Metalloradical Catalysis for Asymmetric Radical Cyclopropanation.
Cheng, Qigan.

Co(II)-Based Metalloradical Catalysis for Asymmetric Radical Cyclopropanation. - Ann Arbor : ProQuest Dissertations & Theses, 2016 - 342 p.

Source: Dissertation Abstracts International, Volume: 77-11(E), Section: B.

Thesis (Ph.D.)--University of South Florida, 2016.

Metal-catalyzed cyclopropanation of olefins with diazo reagents is one of the most general and efficient method to prepare cyclopropanes. The resulting cyclopropyl units are found as a basic structural element in a wide range of naturally occurring compounds and biologically active compounds, and can serve as versatile synthetic intermediates in the synthesis of multifunctionalized cycloalkanes and acyclic compounds. Since Co(II) complexes of D 2-symmetric chiral amidoporphyrins [Co(D2-Por*)] were first introduced in 2004, Co(II)-metalloradical catalysis (MRC) have emerged as a new platform for asymmetric cyclopropanation. These metalloradical catalysts have been shown to be highly effective for asymmetric intermolecular cyclopropanation of a broad scope of substrates with different diazo reagents, with excellent diastereoselectivity and enantioselectivity.

ISBN: 9781339757216Subjects--Topical Terms:

523952
Organic chemistry.

Co(II)-Based Metalloradical Catalysis for Asymmetric Radical Cyclopropanation.
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100 1 $a Cheng, Qigan. $3 3286526
245 1 0 $a Co(II)-Based Metalloradical Catalysis for Asymmetric Radical Cyclopropanation.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2016
300 $a 342 p.
500 $a Source: Dissertation Abstracts International, Volume: 77-11(E), Section: B.
500 $a Advisers: Peter Zhang; Shengqian Ma.
502 $a Thesis (Ph.D.)--University of South Florida, 2016.
520 $a Metal-catalyzed cyclopropanation of olefins with diazo reagents is one of the most general and efficient method to prepare cyclopropanes. The resulting cyclopropyl units are found as a basic structural element in a wide range of naturally occurring compounds and biologically active compounds, and can serve as versatile synthetic intermediates in the synthesis of multifunctionalized cycloalkanes and acyclic compounds. Since Co(II) complexes of D 2-symmetric chiral amidoporphyrins [Co(D2-Por*)] were first introduced in 2004, Co(II)-metalloradical catalysis (MRC) have emerged as a new platform for asymmetric cyclopropanation. These metalloradical catalysts have been shown to be highly effective for asymmetric intermolecular cyclopropanation of a broad scope of substrates with different diazo reagents, with excellent diastereoselectivity and enantioselectivity.
520 $a This dissertation aims to develop new Co(II)-MRC based enantioselective cyclopropanation systems. It will elaborate on three types of stereoselective cyclopropanation reactions from olefins: radical cyclopropanation with ?-halodiazoacetates, asymmetric bicyclization of diazoketones, and radical cyclopropanation with fluoroaryl diazomethanes. These three processes will be examined in the context of diastereo- and enantiocontrol. And also, the application of cyclopropanation products have been demonstrated, which could potentially lead to more exciting works.
590 $a School code: 0206.
650 4 $a Organic chemistry. $3 523952
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710 2 $a University of South Florida. $b Chemistry. $3 2093640
773 0 $t Dissertation Abstracts International $g 77-11B(E).
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856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10112567