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Development of PET neuroimaging meth...

Ouyang, Yu.

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Development of PET neuroimaging methods for stroke and neuroinflammation.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Development of PET neuroimaging methods for stroke and neuroinflammation./
Author:	Ouyang, Yu.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2015,
Description:	125 p.
Notes:	Source: Dissertation Abstracts International, Volume: 77-02(E), Section: B.
Contained By:	Dissertation Abstracts International77-02B(E).
Subject:	Biomedical engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3723695
ISBN:	9781339065779

Development of PET neuroimaging methods for stroke and neuroinflammation.
Ouyang, Yu.

Development of PET neuroimaging methods for stroke and neuroinflammation. - Ann Arbor : ProQuest Dissertations & Theses, 2015 - 125 p.

Source: Dissertation Abstracts International, Volume: 77-02(E), Section: B.

Thesis (Ph.D.)--University of California, Davis, 2015.

This item is not available from ProQuest Dissertations & Theses.

Neuroimaging techniques and applications continue to be explored and further refined as the underlying technology advances. Positron emission tomography (PET) is a highly sensitive imaging modality that has been used both clinically and preclinically to elucidate underlying biochemistry and physiology. Developments in multimodality PET and magnetic resonance imaging (MRI) are pushing the limits of sensitivity and spatial resolution, and have allowed simultaneous acquisition of multimodal data. Within the brain, renewed focus on glial cells and their involvement in a variety of pathologies has resulted in newly proposed applications for existing radiotracers, continued improvement of existing radioligands for neuroreceptor targets, and the development of accompanying pharmacokinetic modeling techniques.

ISBN: 9781339065779Subjects--Topical Terms:

535387
Biomedical engineering.

Development of PET neuroimaging methods for stroke and neuroinflammation.
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100 1 $a Ouyang, Yu. $3 3286164
245 1 0 $a Development of PET neuroimaging methods for stroke and neuroinflammation.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2015
300 $a 125 p.
500 $a Source: Dissertation Abstracts International, Volume: 77-02(E), Section: B.
500 $a Adviser: Simon R. Cherry.
502 $a Thesis (Ph.D.)--University of California, Davis, 2015.
506 $a This item is not available from ProQuest Dissertations & Theses.
520 $a Neuroimaging techniques and applications continue to be explored and further refined as the underlying technology advances. Positron emission tomography (PET) is a highly sensitive imaging modality that has been used both clinically and preclinically to elucidate underlying biochemistry and physiology. Developments in multimodality PET and magnetic resonance imaging (MRI) are pushing the limits of sensitivity and spatial resolution, and have allowed simultaneous acquisition of multimodal data. Within the brain, renewed focus on glial cells and their involvement in a variety of pathologies has resulted in newly proposed applications for existing radiotracers, continued improvement of existing radioligands for neuroreceptor targets, and the development of accompanying pharmacokinetic modeling techniques.
520 $a In this work, several related neuroimaging techniques and tracers were evaluated and developed. Recent work in rodent brain injury models demonstrated elevated lesion uptake of 2-[18F]fluoroacetate ([18 F]FACE), suggesting its possible use for specifically imaging glial metabolism. To assess this hypothesis, we evaluated [18F]FACE kinetics in rodent models of cerebral hypoxia-ischemia. In addition, due to the rapid and variable nature of injury in this animal model, acquisition of both PET and MRI data must be performed simultaneously in order to meaningfully correlate the resulting images. Inter-animal variability in the hypoxic ischemic injury due to vascular differences restricts the ability to analyze multi-modal data and observe changes to a group-wise approach if data is not acquired simultaneously in individual subjects. We present a method for simultaneous imaging of diffusion-weighted MRI and [18F]FDG uptake data in the same animal before, during, and after the hypoxic challenge in order to interrogate immediate physiological changes.
520 $a Imaging of the 18-kDa translocator protein (TSPO) is standard for preclinical assessment of neuroinflammation. Quantification of radioligand binding by estimating the binding potential of the non-displaceable compartment ( BPND) is potentially valuable for measuring the neuroinflammatory response following organophosphate (OP) exposure. [18F]PBR111 is a recently developed second generation TSPO radioligand and it has been previously evaluated in other animal models of neuroinflammation. We present a comparison of input function and reference tissue based methods for estimation of [18F]PBR111 BPND and related parameters in this animal model.
590 $a School code: 0029.
650 4 $a Biomedical engineering. $3 535387
650 4 $a Medical imaging. $3 3172799
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690 $a 0574
710 2 $a University of California, Davis. $b Biomedical Engineering. $3 1035546
773 0 $t Dissertation Abstracts International $g 77-02B(E).
790 $a 0029
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3723695