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Validation of Multiparametric Magnet...

Starobinets, Olga.

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Validation of Multiparametric Magnetic Resonance Imaging Techniques for Evaluating the Prostate.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Validation of Multiparametric Magnetic Resonance Imaging Techniques for Evaluating the Prostate./
Author:	Starobinets, Olga.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2017,
Description:	185 p.
Notes:	Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.
Contained By:	Dissertation Abstracts International78-09B(E).
Subject:	Biomedical engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10264251
ISBN:	9781369737912

Validation of Multiparametric Magnetic Resonance Imaging Techniques for Evaluating the Prostate.
Starobinets, Olga.

Validation of Multiparametric Magnetic Resonance Imaging Techniques for Evaluating the Prostate. - Ann Arbor : ProQuest Dissertations & Theses, 2017 - 185 p.

Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.

Thesis (Ph.D.)--University of California, San Francisco, 2017.

Prostate cancer is extremely common. With recent advancements in cancer detection, an increasing number of men at a younger age face the difficult choice between delaying potentially life-saving interventions and seeking curative treatments, which are typically accompanied by a host of side effects. Non-invasive disease characterization is a promising step toward identifying patient-specific cancer management strategies. Due to the excellent performance of anatomic imaging and the ability to characterize physiologic properties via functional imaging modalities, multiparametic magnetic resonance imaging (mpMRI) has the potential to make a significant impact on the way prostate cancer is viewed by both patients and clinicians.

ISBN: 9781369737912Subjects--Topical Terms:

535387
Biomedical engineering.

Validation of Multiparametric Magnetic Resonance Imaging Techniques for Evaluating the Prostate.
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020 $a 9781369737912
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100 1 $a Starobinets, Olga. $3 3286124
245 1 0 $a Validation of Multiparametric Magnetic Resonance Imaging Techniques for Evaluating the Prostate.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2017
300 $a 185 p.
500 $a Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.
500 $a Adviser: John Kurhanewicz.
502 $a Thesis (Ph.D.)--University of California, San Francisco, 2017.
520 $a Prostate cancer is extremely common. With recent advancements in cancer detection, an increasing number of men at a younger age face the difficult choice between delaying potentially life-saving interventions and seeking curative treatments, which are typically accompanied by a host of side effects. Non-invasive disease characterization is a promising step toward identifying patient-specific cancer management strategies. Due to the excellent performance of anatomic imaging and the ability to characterize physiologic properties via functional imaging modalities, multiparametic magnetic resonance imaging (mpMRI) has the potential to make a significant impact on the way prostate cancer is viewed by both patients and clinicians.
520 $a This thesis will introduce multiparametric MR imaging in the context of prostate anatomy. It will address the issues of aligning MR imaging to the whole-mount histopathology images (commonly regarded as a reference standard) and discuss characterization and stratification of prostatic lesions based on mpMR imaging. This work will also introduce a semi-automatic approach to lesion segmentation on histopathology and report on the prostate cancer composition in the radical prostatectomy population. Furthermore, this thesis will investigate the prevalence of "sparse" prostatic lesions, discussing their clinical significance and exploring mpMRI capabilities to detect these cancers. Finally, this work will examine the influence of prostate treatments, specifically 5-alpha reductase inhibitors (often used to treat benign prostatic hyperplasia), on the structure of prostatic tissues, their effect on the appearance of prostatic tissues on mpMRI, and what role such treatments play in our ability to properly detect malignancies post treatment.
590 $a School code: 0034.
650 4 $a Biomedical engineering. $3 535387
650 4 $a Medical imaging. $3 3172799
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690 $a 0574
710 2 $a University of California, San Francisco. $b Bioengineering. $3 1025199
773 0 $t Dissertation Abstracts International $g 78-09B(E).
790 $a 0034
791 $a Ph.D.
792 $a 2017
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10264251