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Cell Lineage Specification during Mo...

Lin, Yi-Tzu.

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Cell Lineage Specification during Mouse Embryonic Gonad Development.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Cell Lineage Specification during Mouse Embryonic Gonad Development./
Author:	Lin, Yi-Tzu.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2017,
Description:	136 p.
Notes:	Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.
Contained By:	Dissertation Abstracts International78-09B(E).
Subject:	Cellular biology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10261641
ISBN:	9781369723984

Cell Lineage Specification during Mouse Embryonic Gonad Development.
Lin, Yi-Tzu.

Cell Lineage Specification during Mouse Embryonic Gonad Development. - Ann Arbor : ProQuest Dissertations & Theses, 2017 - 136 p.

Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.

Thesis (Ph.D.)--Duke University, 2017.

The mouse embryonic gonad provides an outstanding model to study the complex mechanisms involved in cell fate specification and maintenance. At the bipotential stage, both XX and XY gonads are capable of becoming testes or ovaries upon specific molecular cues. The specification of the supporting cell lineage (as either Sertoli cells in the male or granulosa cells in the female) initiates the testis or ovary program, leading to male or female fate. However, there are significant gaps in our understanding of how the somatic cells in the gonad arise, are competent to differentiate, and determine and maintain their fates. In this dissertation, we addressed these questions. (Abstract shortened by ProQuest.).

ISBN: 9781369723984Subjects--Topical Terms:

3172791
Cellular biology.

Cell Lineage Specification during Mouse Embryonic Gonad Development.
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245 1 0 $a Cell Lineage Specification during Mouse Embryonic Gonad Development.
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300 $a 136 p.
500 $a Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.
500 $a Advisers: Blanche Capel; David McClay.
502 $a Thesis (Ph.D.)--Duke University, 2017.
520 $a The mouse embryonic gonad provides an outstanding model to study the complex mechanisms involved in cell fate specification and maintenance. At the bipotential stage, both XX and XY gonads are capable of becoming testes or ovaries upon specific molecular cues. The specification of the supporting cell lineage (as either Sertoli cells in the male or granulosa cells in the female) initiates the testis or ovary program, leading to male or female fate. However, there are significant gaps in our understanding of how the somatic cells in the gonad arise, are competent to differentiate, and determine and maintain their fates. In this dissertation, we addressed these questions. (Abstract shortened by ProQuest.).
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650 4 $a Cellular biology. $3 3172791
650 4 $a Developmental biology. $3 592588
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