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Measurement of Hair Cortisol Concent...

Smy, Laura.

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Measurement of Hair Cortisol Concentration in Pregnant Women and Children with Asthma to Assess Its Potential as a Biomarker of the Hypothalamic-Pituitary-Adrenal Axis.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Measurement of Hair Cortisol Concentration in Pregnant Women and Children with Asthma to Assess Its Potential as a Biomarker of the Hypothalamic-Pituitary-Adrenal Axis./
作者:	Smy, Laura.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2016,
面頁冊數:	161 p.
附註:	Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.
Contained By:	Dissertation Abstracts International78-09B(E).
標題:	Pharmaceutical sciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10191132
ISBN:	9781369707380

Measurement of Hair Cortisol Concentration in Pregnant Women and Children with Asthma to Assess Its Potential as a Biomarker of the Hypothalamic-Pituitary-Adrenal Axis.
Smy, Laura.

Measurement of Hair Cortisol Concentration in Pregnant Women and Children with Asthma to Assess Its Potential as a Biomarker of the Hypothalamic-Pituitary-Adrenal Axis. - Ann Arbor : ProQuest Dissertations & Theses, 2016 - 161 p.

Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2016.

The recommended long-term treatment for asthma is inhaled corticosteroid (ICS) therapy, but research has shown that ICS use is associated with adrenal suppression. Cortisol is important physiologically and involved in fetal maturation and epigenetic programming. Hair cortisol has been used as a biomarker of the long-term effects on the hypothalamic-pituitary- adrenal (HPA) axis for a variety of psychiatric and medical conditions. This research hypothesizes that hair cortisol may be able to detect lower cortisol concentrations in pregnant women and children on ICS therapy and, therefore, have potential as a useful biomarker for possible adrenal suppression due to ICS use.

ISBN: 9781369707380Subjects--Topical Terms:

3173021
Pharmaceutical sciences.

Measurement of Hair Cortisol Concentration in Pregnant Women and Children with Asthma to Assess Its Potential as a Biomarker of the Hypothalamic-Pituitary-Adrenal Axis.
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245 1 0 $a Measurement of Hair Cortisol Concentration in Pregnant Women and Children with Asthma to Assess Its Potential as a Biomarker of the Hypothalamic-Pituitary-Adrenal Axis.
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500 $a Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.
500 $a Advisers: Shinya Ito; Gideon Koren.
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520 $a The recommended long-term treatment for asthma is inhaled corticosteroid (ICS) therapy, but research has shown that ICS use is associated with adrenal suppression. Cortisol is important physiologically and involved in fetal maturation and epigenetic programming. Hair cortisol has been used as a biomarker of the long-term effects on the hypothalamic-pituitary- adrenal (HPA) axis for a variety of psychiatric and medical conditions. This research hypothesizes that hair cortisol may be able to detect lower cortisol concentrations in pregnant women and children on ICS therapy and, therefore, have potential as a useful biomarker for possible adrenal suppression due to ICS use.
520 $a This retrospective cohort study collected hair samples from children and pregnant women with asthma, treated and not treated with ICS, and those without asthma. Hair samples were segmented, based on an average growth of 1 cm/month, and analyzed using a validated ELISA method. A children's pilot study analyzed the hair prior to and during ICS therapy for the same children. The proximal 3 cm hair segment was analyzed for the large cohort of children. Hair segments for preconception, trimesters 1-3, and postpartum were analyzed for the pregnant women. The results were compared within and among the groups, as appropriate.
520 $a The children's pilot study showed hair cortisol concentrations were twofold lower during ICS therapy (median 89.8 ng/g vs. 198.2 ng/g, p=0.0015, n=18). For pregnant women (n=118), asthma was a significant factor associated with lower hair cortisol. Women with asthma and consistent ICS use had significantly lower third trimester hair cortisol (47%, p=0.029) compared to Controls. The comparison of median hair cortisol concentrations among the three groups in the large cohort of children ( n=460) was not significant. However, 5.3% of children on ICS therapy had hair cortisol below 2 ng/g compared to none in the control groups, which may indicate children with or at risk of adrenal suppression. The significant factors associated with hair cortisol in children were age, female sex, intranasal corticosteroid use, and BMI.
520 $a Hair cortisol analysis successfully detected significantly lower hair cortisol concentrations suggesting it is a useful biomarker of the HPA axis in pregnant women and children. The correlation of hair cortisol concentrations with a diagnosis of adrenal suppression or insufficiency and the potential impact of decreased maternal cortisol in women with asthma on perinatal outcomes remain to be determined.
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