東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Measurement of Hair Cortisol Concent...

Smy, Laura.

Linked to FindBook

Google Book

Amazon

博客來

Measurement of Hair Cortisol Concentration in Pregnant Women and Children with Asthma to Assess Its Potential as a Biomarker of the Hypothalamic-Pituitary-Adrenal Axis.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Measurement of Hair Cortisol Concentration in Pregnant Women and Children with Asthma to Assess Its Potential as a Biomarker of the Hypothalamic-Pituitary-Adrenal Axis./
Author:	Smy, Laura.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2016,
Description:	161 p.
Notes:	Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.
Contained By:	Dissertation Abstracts International78-09B(E).
Subject:	Pharmaceutical sciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10191132
ISBN:	9781369707380

Measurement of Hair Cortisol Concentration in Pregnant Women and Children with Asthma to Assess Its Potential as a Biomarker of the Hypothalamic-Pituitary-Adrenal Axis.
Smy, Laura.

Measurement of Hair Cortisol Concentration in Pregnant Women and Children with Asthma to Assess Its Potential as a Biomarker of the Hypothalamic-Pituitary-Adrenal Axis. - Ann Arbor : ProQuest Dissertations & Theses, 2016 - 161 p.

Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2016.

The recommended long-term treatment for asthma is inhaled corticosteroid (ICS) therapy, but research has shown that ICS use is associated with adrenal suppression. Cortisol is important physiologically and involved in fetal maturation and epigenetic programming. Hair cortisol has been used as a biomarker of the long-term effects on the hypothalamic-pituitary- adrenal (HPA) axis for a variety of psychiatric and medical conditions. This research hypothesizes that hair cortisol may be able to detect lower cortisol concentrations in pregnant women and children on ICS therapy and, therefore, have potential as a useful biomarker for possible adrenal suppression due to ICS use.

ISBN: 9781369707380Subjects--Topical Terms:

3173021
Pharmaceutical sciences.

Measurement of Hair Cortisol Concentration in Pregnant Women and Children with Asthma to Assess Its Potential as a Biomarker of the Hypothalamic-Pituitary-Adrenal Axis.
LDR:03630nmm a2200337 4500 001 2124015
005 20171023101704.5
008 180830s2016 ||||||||||||||||| ||eng d
020 $a 9781369707380
035 $a (MiAaPQ)AAI10191132
035 $a AAI10191132
040 $a MiAaPQ $c MiAaPQ
100 1 $a Smy, Laura. $3 3285979
245 1 0 $a Measurement of Hair Cortisol Concentration in Pregnant Women and Children with Asthma to Assess Its Potential as a Biomarker of the Hypothalamic-Pituitary-Adrenal Axis.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2016
300 $a 161 p.
500 $a Source: Dissertation Abstracts International, Volume: 78-09(E), Section: B.
500 $a Advisers: Shinya Ito; Gideon Koren.
502 $a Thesis (Ph.D.)--University of Toronto (Canada), 2016.
520 $a The recommended long-term treatment for asthma is inhaled corticosteroid (ICS) therapy, but research has shown that ICS use is associated with adrenal suppression. Cortisol is important physiologically and involved in fetal maturation and epigenetic programming. Hair cortisol has been used as a biomarker of the long-term effects on the hypothalamic-pituitary- adrenal (HPA) axis for a variety of psychiatric and medical conditions. This research hypothesizes that hair cortisol may be able to detect lower cortisol concentrations in pregnant women and children on ICS therapy and, therefore, have potential as a useful biomarker for possible adrenal suppression due to ICS use.
520 $a This retrospective cohort study collected hair samples from children and pregnant women with asthma, treated and not treated with ICS, and those without asthma. Hair samples were segmented, based on an average growth of 1 cm/month, and analyzed using a validated ELISA method. A children's pilot study analyzed the hair prior to and during ICS therapy for the same children. The proximal 3 cm hair segment was analyzed for the large cohort of children. Hair segments for preconception, trimesters 1-3, and postpartum were analyzed for the pregnant women. The results were compared within and among the groups, as appropriate.
520 $a The children's pilot study showed hair cortisol concentrations were twofold lower during ICS therapy (median 89.8 ng/g vs. 198.2 ng/g, p=0.0015, n=18). For pregnant women (n=118), asthma was a significant factor associated with lower hair cortisol. Women with asthma and consistent ICS use had significantly lower third trimester hair cortisol (47%, p=0.029) compared to Controls. The comparison of median hair cortisol concentrations among the three groups in the large cohort of children ( n=460) was not significant. However, 5.3% of children on ICS therapy had hair cortisol below 2 ng/g compared to none in the control groups, which may indicate children with or at risk of adrenal suppression. The significant factors associated with hair cortisol in children were age, female sex, intranasal corticosteroid use, and BMI.
520 $a Hair cortisol analysis successfully detected significantly lower hair cortisol concentrations suggesting it is a useful biomarker of the HPA axis in pregnant women and children. The correlation of hair cortisol concentrations with a diagnosis of adrenal suppression or insufficiency and the potential impact of decreased maternal cortisol in women with asthma on perinatal outcomes remain to be determined.
590 $a School code: 0779.
650 4 $a Pharmaceutical sciences. $3 3173021
650 4 $a Endocrinology. $3 610914
650 4 $a Toxicology. $3 556884
690 $a 0572
690 $a 0409
690 $a 0383
710 2 $a University of Toronto (Canada). $b Pharmaceutical Sciences. $3 3170825
773 0 $t Dissertation Abstracts International $g 78-09B(E).
790 $a 0779
791 $a Ph.D.
792 $a 2016
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10191132