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Using Fluorescence -- Polarization E...

Charanya, Tauseef.

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Using Fluorescence -- Polarization Endoscopy in Detection of Precancerous and Cancerous Lesions in Colon and Pancreatic Cancer.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Using Fluorescence -- Polarization Endoscopy in Detection of Precancerous and Cancerous Lesions in Colon and Pancreatic Cancer./
Author:	Charanya, Tauseef.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2015,
Description:	175 p.
Notes:	Source: Dissertation Abstracts International, Volume: 77-02(E), Section: B.
Contained By:	Dissertation Abstracts International77-02B(E).
Subject:	Biomedical engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3724758
ISBN:	9781339083940

Using Fluorescence -- Polarization Endoscopy in Detection of Precancerous and Cancerous Lesions in Colon and Pancreatic Cancer.
Charanya, Tauseef.

Using Fluorescence -- Polarization Endoscopy in Detection of Precancerous and Cancerous Lesions in Colon and Pancreatic Cancer. - Ann Arbor : ProQuest Dissertations & Theses, 2015 - 175 p.

Source: Dissertation Abstracts International, Volume: 77-02(E), Section: B.

Thesis (Ph.D.)--Washington University in St. Louis, 2015.

This item is not available from ProQuest Dissertations & Theses.

Colitis-associated cancer (CAC) arises from premalignant flat lesions of the colon, which are difficult to detect with current endoscopic screening approaches. We have developed a complementary fluorescence and polarization reporting strategy that combines the unique biochemical and physical properties of dysplasia and cancer for real time detection of these lesions. Utilizing a new thermoresponsive sol-gel formulation with targeted molecular probe allowed topical application and detection of precancerous and cancerous lesions during endoscopy. Incorporation of nanowire-filtered polarization imaging into NIR fluorescence endoscopy served as a validation strategy prior to obtaining biopsies.

ISBN: 9781339083940Subjects--Topical Terms:

535387
Biomedical engineering.

Using Fluorescence -- Polarization Endoscopy in Detection of Precancerous and Cancerous Lesions in Colon and Pancreatic Cancer.
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100 1 $a Charanya, Tauseef. $3 3284759
245 1 0 $a Using Fluorescence -- Polarization Endoscopy in Detection of Precancerous and Cancerous Lesions in Colon and Pancreatic Cancer.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2015
300 $a 175 p.
500 $a Source: Dissertation Abstracts International, Volume: 77-02(E), Section: B.
500 $a Adviser: Samuel Achilefu.
502 $a Thesis (Ph.D.)--Washington University in St. Louis, 2015.
506 $a This item is not available from ProQuest Dissertations & Theses.
520 $a Colitis-associated cancer (CAC) arises from premalignant flat lesions of the colon, which are difficult to detect with current endoscopic screening approaches. We have developed a complementary fluorescence and polarization reporting strategy that combines the unique biochemical and physical properties of dysplasia and cancer for real time detection of these lesions. Utilizing a new thermoresponsive sol-gel formulation with targeted molecular probe allowed topical application and detection of precancerous and cancerous lesions during endoscopy. Incorporation of nanowire-filtered polarization imaging into NIR fluorescence endoscopy served as a validation strategy prior to obtaining biopsies.
520 $a In order to reduce repeat surgeries arising from incomplete tumor resection, we demonstrated the efficacy of the targeted molecular probe towards margins of sporadic colorectal cancer (SCC). Fluorescence-polarization microscopy using circular polarized (CP) light served as a rapid, supplementary tool for assessment and validation of excised tissue to ensure complete tumor resection for examining tumor margins prior to H&E pathological diagnosis. We extended our platform towards non-invasive directed detection of pancreatic cancer utilizing fluorescence molecular tomography (FMT) and NIR laparoscopy using identified targeted molecular probe. We were able to non-invasively distinguished between pancreatitis and pancreatic cancer and guide pancreatic tumor resection using NIR laparoscopy.
590 $a School code: 0252.
650 4 $a Biomedical engineering. $3 535387
650 4 $a Medical imaging. $3 3172799
650 4 $a Engineering. $3 586835
650 4 $a Oncology. $3 751006
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710 2 $a Washington University in St. Louis. $b Biomedical Engineering. $3 1669544
773 0 $t Dissertation Abstracts International $g 77-02B(E).
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