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Development of a single channel tera...

Doradla, Pallavi.

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Development of a single channel terahertz endoscopic system for cancer detection.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Development of a single channel terahertz endoscopic system for cancer detection./
Author:	Doradla, Pallavi.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2015,
Description:	150 p.
Notes:	Source: Dissertation Abstracts International, Volume: 76-04(E), Section: B.
Contained By:	Dissertation Abstracts International76-04B(E).
Subject:	Optics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3581974
ISBN:	9781321442144

Development of a single channel terahertz endoscopic system for cancer detection.
Doradla, Pallavi.

Development of a single channel terahertz endoscopic system for cancer detection. - Ann Arbor : ProQuest Dissertations & Theses, 2015 - 150 p.

Source: Dissertation Abstracts International, Volume: 76-04(E), Section: B.

Thesis (Ph.D.)--University of Massachusetts Lowell, 2015.

Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the world. The gold standard for colorectal cancer diagnosis is the conventional colonoscopy which relies exclusively on a physician's experience. Conventional techniques such as X-ray and MRI provide low resolution images of living tissue at macroscopic levels. To obtain structural and functional information of an organ, microscopic imaging will be performed. However, it is limited to biopsied samples. Currently there is no technique that can noninvasively provide high resolution images of living tissue by combining both macroscopic and microscopic information. Using terahertz radiation with wavelengths ranging from micrometer to millimeter can potentially fix this niche. The terahertz frequency range, located midway between the microwave and infrared regions, has become increasingly relevant for biomedical applications due to its non-ionizing nature and sensitivity to water content. The aim of this thesis is to investigate the viability of constructing a terahertz endoscope as an additional tool to aid colorectal cancer screening. This involves investigating the terahertz response of cancerous colon tissue and demonstrating observable contrast levels between normal and abnormal regions when imaging in reflection modality through a flexible terahertz waveguide.

ISBN: 9781321442144Subjects--Topical Terms:

517925
Optics.

Development of a single channel terahertz endoscopic system for cancer detection.
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100 1 $a Doradla, Pallavi. $3 3284740
245 1 0 $a Development of a single channel terahertz endoscopic system for cancer detection.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2015
300 $a 150 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-04(E), Section: B.
500 $a Adviser: Robert H. Giles.
502 $a Thesis (Ph.D.)--University of Massachusetts Lowell, 2015.
520 $a Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the world. The gold standard for colorectal cancer diagnosis is the conventional colonoscopy which relies exclusively on a physician's experience. Conventional techniques such as X-ray and MRI provide low resolution images of living tissue at macroscopic levels. To obtain structural and functional information of an organ, microscopic imaging will be performed. However, it is limited to biopsied samples. Currently there is no technique that can noninvasively provide high resolution images of living tissue by combining both macroscopic and microscopic information. Using terahertz radiation with wavelengths ranging from micrometer to millimeter can potentially fix this niche. The terahertz frequency range, located midway between the microwave and infrared regions, has become increasingly relevant for biomedical applications due to its non-ionizing nature and sensitivity to water content. The aim of this thesis is to investigate the viability of constructing a terahertz endoscope as an additional tool to aid colorectal cancer screening. This involves investigating the terahertz response of cancerous colon tissue and demonstrating observable contrast levels between normal and abnormal regions when imaging in reflection modality through a flexible terahertz waveguide.
520 $a First, hollow-core flexible waveguides have been designed and fabricated for the maximal transmission of terahertz radiation. Attenuation characteristics of metal and metal/dielectric coated polycarbonate waveguides with various bore diameters were measured as a function of wavelength, bore diameter, bending angle, and bend radius. The experimental approach determines the feasibility of using these flexible waveguides at various terahertz frequencies by examining the attenuation and modal characteristics at greater bending angles.
520 $a The continuous-wave terahertz imaging has the potential to offer a safe, noninvasive medical imaging modality for delineating colorectal cancers. To test this hypothesis, the reflectance measurements of human colonic tissues were acquired using an ex vivo continuous-wave terahertz imaging system. To confirm system imaging frequency and evaluate base contrast, the two-dimensional THz reflection images of colonic tissues were obtained using a polarization specific detection technique. The resulting terahertz reflection images were compared with the tissue histology. Therefore, this stage confirms the observable contrast levels at the selected imaging frequency.
520 $a To determine the feasibility of using terahertz endoscope for cancer detection; a thin, low-loss, hollow, flexible terahertz waveguide is integrated with a reflectance based imaging system. Unlike the previously reported techniques, this study demonstrates the prototype terahertz endoscopic system utilizing a single channel to transmit and collect the back reflected intrinsic terahertz signal from the sample. This device operates in both transmission and reflection modalities to fulfil the in vivo imaging criteria. The ex vivo terahertz polarization images of normal and cancerous tissue specimens were acquired to determine the contrast levels. The level of contrast observed using waveguide enabled imaging system was compared with the free space studies.
520 $a Finally, this study demonstrates the first single-channel terahertz endoscopic system and determines the feasibility of using the terahertz endoscopie technology to aid in vivo cancer screening.
590 $a School code: 0111.
650 4 $a Optics. $3 517925
650 4 $a Medical imaging. $3 3172799
690 $a 0752
690 $a 0574
710 2 $a University of Massachusetts Lowell. $3 1017839
773 0 $t Dissertation Abstracts International $g 76-04B(E).
790 $a 0111
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3581974