語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
The Use of Metabolomic Profiling to ...
~
Martin, Elizabeth Marie.
FindBook
Google Book
Amazon
博客來
The Use of Metabolomic Profiling to Elucidate Mechanisms Underlying Arsenic-Associated Diabetes.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
The Use of Metabolomic Profiling to Elucidate Mechanisms Underlying Arsenic-Associated Diabetes./
作者:
Martin, Elizabeth Marie.
出版者:
Ann Arbor : ProQuest Dissertations & Theses, : 2017,
面頁冊數:
132 p.
附註:
Source: Dissertation Abstracts International, Volume: 78-11(E), Section: B.
Contained By:
Dissertation Abstracts International78-11B(E).
標題:
Environmental health. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10264135
ISBN:
9781369872842
The Use of Metabolomic Profiling to Elucidate Mechanisms Underlying Arsenic-Associated Diabetes.
Martin, Elizabeth Marie.
The Use of Metabolomic Profiling to Elucidate Mechanisms Underlying Arsenic-Associated Diabetes.
- Ann Arbor : ProQuest Dissertations & Theses, 2017 - 132 p.
Source: Dissertation Abstracts International, Volume: 78-11(E), Section: B.
Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2017.
Arsenic is a naturally occurring metalloid that is associated with numerous health effects. More than 100 million individuals are exposed globally to high levels of arsenic chronically through contaminated drinking water sources. Studies have shown these individuals are more likely to develop Diabetes Mellitus (DM). At present, the National Toxicology Program has classified chronic exposure to arsenic above 150 microg/L as a probable diabtogen. Furthermore, more recent epidemiological studies have highlighted that chronic arsenic exposure above 150 microg/L maybe associated with DM. While in vitro and in vivo studies have elucidated possible mechanisms by which arsenic induces diabetes, it is still unclear which of these mechanisms is fully relevant to humans. Metabolomic profiling could help provide key insights into metabolic alterations that occur in individuals exposed to arsenic that lead to diabetes. As metabolomics is an emerging field profiling both diabetic and non-diabetic individuals chronically exposed to arsenic could provide insight into metabolic alterations associated with chronic arsenic exposure, as well as insight into which of these alterations are associated with the development of diabetes.
ISBN: 9781369872842Subjects--Topical Terms:
543032
Environmental health.
The Use of Metabolomic Profiling to Elucidate Mechanisms Underlying Arsenic-Associated Diabetes.
LDR
:03361nmm a2200301 4500
001
2122669
005
20170922124936.5
008
180830s2017 ||||||||||||||||| ||eng d
020
$a
9781369872842
035
$a
(MiAaPQ)AAI10264135
035
$a
AAI10264135
040
$a
MiAaPQ
$c
MiAaPQ
100
1
$a
Martin, Elizabeth Marie.
$3
3284636
245
1 4
$a
The Use of Metabolomic Profiling to Elucidate Mechanisms Underlying Arsenic-Associated Diabetes.
260
1
$a
Ann Arbor :
$b
ProQuest Dissertations & Theses,
$c
2017
300
$a
132 p.
500
$a
Source: Dissertation Abstracts International, Volume: 78-11(E), Section: B.
500
$a
Adviser: Rebecca C. Fry.
502
$a
Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2017.
520
$a
Arsenic is a naturally occurring metalloid that is associated with numerous health effects. More than 100 million individuals are exposed globally to high levels of arsenic chronically through contaminated drinking water sources. Studies have shown these individuals are more likely to develop Diabetes Mellitus (DM). At present, the National Toxicology Program has classified chronic exposure to arsenic above 150 microg/L as a probable diabtogen. Furthermore, more recent epidemiological studies have highlighted that chronic arsenic exposure above 150 microg/L maybe associated with DM. While in vitro and in vivo studies have elucidated possible mechanisms by which arsenic induces diabetes, it is still unclear which of these mechanisms is fully relevant to humans. Metabolomic profiling could help provide key insights into metabolic alterations that occur in individuals exposed to arsenic that lead to diabetes. As metabolomics is an emerging field profiling both diabetic and non-diabetic individuals chronically exposed to arsenic could provide insight into metabolic alterations associated with chronic arsenic exposure, as well as insight into which of these alterations are associated with the development of diabetes.
520
$a
The goal of this research was to identify metabolites associated with alterations in associated with arsenic exposure in diabetic and non-diabetic individuals in Chihuahua, Mexico. Using 492 unique metabolites in urine and plasma through an untargeted metabolomic screening, we assessed the relationship between these metabolites total urinary arsenic (U-tAs), a commonly used measure of arsenic exposure, arsenic metabolism, as measured through speciated urinary arsenicals, and genotype of Arsenic +3 oxidation state methyltransferase ( AS3MT), the main enzyme responsible for arsenic metabolism. We demonstrated that the identified metabolites are associated with alterations of key metabolic pathways including glucose metabolism, amino acid metabolism and vitamin B metabolism in association with arsenic exposure, arsenic metabolism and genotype of AS3MT in both diabetic and non-diabetic subjects. Many of the identified metabolites are associated with enzymes and metabolic pathways associated with the development of diabetes. Taken together, our research increase knowledge of mechanistic associations between arsenic-associated diabetes in humans.
590
$a
School code: 0153.
650
4
$a
Environmental health.
$3
543032
650
4
$a
Health sciences.
$3
3168359
690
$a
0470
690
$a
0566
710
2
$a
The University of North Carolina at Chapel Hill.
$b
Environmental Sciences and Engineering.
$3
2104684
773
0
$t
Dissertation Abstracts International
$g
78-11B(E).
790
$a
0153
791
$a
Ph.D.
792
$a
2017
793
$a
English
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10264135
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9333283
電子資源
01.外借(書)_YB
電子書
EB
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入