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Lung cancer in Nepal: The role of tr...

Raspanti, Greg A.

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Lung cancer in Nepal: The role of traditional tobacco products and household air pollution.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Lung cancer in Nepal: The role of traditional tobacco products and household air pollution./
Author:	Raspanti, Greg A.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2016,
Description:	188 p.
Notes:	Source: Dissertation Abstracts International, Volume: 77-10(E), Section: B.
Contained By:	Dissertation Abstracts International77-10B(E).
Subject:	Environmental health. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10130009
ISBN:	9781339878737

Lung cancer in Nepal: The role of traditional tobacco products and household air pollution.
Raspanti, Greg A.

Lung cancer in Nepal: The role of traditional tobacco products and household air pollution. - Ann Arbor : ProQuest Dissertations & Theses, 2016 - 188 p.

Source: Dissertation Abstracts International, Volume: 77-10(E), Section: B.

Thesis (Ph.D.)--University of Maryland, College Park, 2016.

The burden of chronic diseases such as cancer is increasing in low and middle income countries around the globe. Nepal, one of the world's poorest countries, is no exception to this trend, with lung cancer as the leading causes of cancer deaths. Despite this, limited data is available on the environmental and behavioral risk factors that contribute to the lung cancer etiology in Nepal. The objectives of this dissertation are to: 1) investigate the ethnic differences in consumption of local tobacco products and their role in lung cancer risk in Nepal; 2) evaluate urinary metabolite of 1,3-butadiene as a biomarker of exposure to combustion related household air pollution (CRHAP); 3) investigate the association between CRHAP exposure and lung cancer risk using urinary metabolite of 1,3-butadiene as a biomarker of exposure; 4) investigate the association between CRHAP exposure and lung cancer risk using questionnaire based measure of exposure.

ISBN: 9781339878737Subjects--Topical Terms:

543032
Environmental health.

Lung cancer in Nepal: The role of traditional tobacco products and household air pollution.
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100 1 $a Raspanti, Greg A. $3 3284389
245 1 0 $a Lung cancer in Nepal: The role of traditional tobacco products and household air pollution.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2016
300 $a 188 p.
500 $a Source: Dissertation Abstracts International, Volume: 77-10(E), Section: B.
500 $a Adviser: Amir Sapkota.
502 $a Thesis (Ph.D.)--University of Maryland, College Park, 2016.
520 $a The burden of chronic diseases such as cancer is increasing in low and middle income countries around the globe. Nepal, one of the world's poorest countries, is no exception to this trend, with lung cancer as the leading causes of cancer deaths. Despite this, limited data is available on the environmental and behavioral risk factors that contribute to the lung cancer etiology in Nepal. The objectives of this dissertation are to: 1) investigate the ethnic differences in consumption of local tobacco products and their role in lung cancer risk in Nepal; 2) evaluate urinary metabolite of 1,3-butadiene as a biomarker of exposure to combustion related household air pollution (CRHAP); 3) investigate the association between CRHAP exposure and lung cancer risk using urinary metabolite of 1,3-butadiene as a biomarker of exposure; 4) investigate the association between CRHAP exposure and lung cancer risk using questionnaire based measure of exposure.
520 $a Lung cancer cases (n=606) and frequency matched controls (N=606) were recruited from B.P. Koirala Memorial Cancer Hospital. We obtained biological samples and information on lifestyles including cooking habits and type of fuels used. We used liquid chromatograph tandem mass spectrometer (LC-MS/MS) to quantify urinary metabolites of 1,3-butadiene in urine samples. We employed a combination of logistic and linear regression models to detect any exposure-disease associations while controlling for known confounding variables.
520 $a Overall, we found that ethnic groups in Nepal use different tobacco products that have different differing cancer potency -we observed the highest odds ratios for the traditional tobacco products. The biomarker analysis showed strong evidence that monohydroxybutyl mercapturic acid is associated with biomass fuel use among participants. However, we did not find significant association between urinary MHMBA and lung cancer risk. When we used questionnaire based measure of exposure to household air pollution, we observed significant, dose-response associations between CRHAP exposure and lung cancer risk, particularly among never-smokers. Our results show that important role of local tobacco products in lung cancer risk in Nepal. Furthermore, we demonstrate that CRHAP exposure is a risk factor for lung cancer risk, independent of tobacco smoking.
590 $a School code: 0117.
650 4 $a Environmental health. $3 543032
650 4 $a Toxicology. $3 556884
650 4 $a South Asian studies. $3 3172880
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710 2 $a University of Maryland, College Park. $b Applied Environmental Health. $3 3284390
773 0 $t Dissertation Abstracts International $g 77-10B(E).
790 $a 0117
791 $a Ph.D.
792 $a 2016
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10130009