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Hippocampal CA1 activation during ob...

Cinalli, David A., Jr.

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Hippocampal CA1 activation during object memory encoding in the novel object recognition task.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Hippocampal CA1 activation during object memory encoding in the novel object recognition task./
Author:	Cinalli, David A., Jr.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2015,
Description:	73 p.
Notes:	Source: Masters Abstracts International, Volume: 55-02.
Contained By:	Masters Abstracts International55-02(E).
Subject:	Neurosciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1602471
ISBN:	9781339170329

Hippocampal CA1 activation during object memory encoding in the novel object recognition task.
Cinalli, David A., Jr.

Hippocampal CA1 activation during object memory encoding in the novel object recognition task. - Ann Arbor : ProQuest Dissertations & Theses, 2015 - 73 p.

Source: Masters Abstracts International, Volume: 55-02.

Thesis (M.A.)--Florida Atlantic University, 2015.

Transcription and translation of proteins are required for the consolidation of episodic memory. Arc, an effector immediate early gene, has been linked to synaptic plasticity following learning and memory. It is well established that the rodent hippocampus is essential for processing spatial memory, but its role in processing object memory is a point of contention. Using immunohistochemical techniques, hippocampal sections were stained for arc proteins in the CA1 region of the dorsal hippocampus in mice following two variations of the novel object recognition (NOR) task. Results suggest mice that acquired strong object memory showed significant hippocampal activation. In mice that acquired weak object memory, hippocampal activation was not significantly different from controls. Arc expression was also examined in other hippocampal sub-regions, as well as in the perirhinal cortex. These results suggest that the mice must acquire a threshold amount of object information before the hippocampal CA1 region is engaged.

ISBN: 9781339170329Subjects--Topical Terms:

588700
Neurosciences.

Hippocampal CA1 activation during object memory encoding in the novel object recognition task.
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245 1 0 $a Hippocampal CA1 activation during object memory encoding in the novel object recognition task.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2015
300 $a 73 p.
500 $a Source: Masters Abstracts International, Volume: 55-02.
500 $a Adviser: Robert W. Stackman, Jr.
502 $a Thesis (M.A.)--Florida Atlantic University, 2015.
520 $a Transcription and translation of proteins are required for the consolidation of episodic memory. Arc, an effector immediate early gene, has been linked to synaptic plasticity following learning and memory. It is well established that the rodent hippocampus is essential for processing spatial memory, but its role in processing object memory is a point of contention. Using immunohistochemical techniques, hippocampal sections were stained for arc proteins in the CA1 region of the dorsal hippocampus in mice following two variations of the novel object recognition (NOR) task. Results suggest mice that acquired strong object memory showed significant hippocampal activation. In mice that acquired weak object memory, hippocampal activation was not significantly different from controls. Arc expression was also examined in other hippocampal sub-regions, as well as in the perirhinal cortex. These results suggest that the mice must acquire a threshold amount of object information before the hippocampal CA1 region is engaged.
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