東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

A biochemical linkage between methan...

Oza, Javin Pradip.

Linked to FindBook

Google Book

Amazon

博客來

A biochemical linkage between methanogenesis and protein synthesis in hydrogenotrophic archaea.

Record Type:	Electronic resources : Monograph/item
Title/Author:	A biochemical linkage between methanogenesis and protein synthesis in hydrogenotrophic archaea./
Author:	Oza, Javin Pradip.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2012,
Description:	214 p.
Notes:	Source: Dissertation Abstracts International, Volume: 74-02(E), Section: B.
Contained By:	Dissertation Abstracts International74-02B(E).
Subject:	Biochemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3540206
ISBN:	9781267648686

A biochemical linkage between methanogenesis and protein synthesis in hydrogenotrophic archaea.
Oza, Javin Pradip.

A biochemical linkage between methanogenesis and protein synthesis in hydrogenotrophic archaea. - Ann Arbor : ProQuest Dissertations & Theses, 2012 - 214 p.

Source: Dissertation Abstracts International, Volume: 74-02(E), Section: B.

Thesis (Ph.D.)--University of California, Santa Barbara, 2012.

Hydrogenotrophic methanogens possessing the hydrogen-dependent dehydrogenase Hmd also encode paralogs of this protein whose function is poorly understood. Here we present biochemical evidence that the two inactive Hmd paralogs of Methanocaldococcus jannaschii, HmdII and HmdIII, form binary and ternary complexes with several components of the protein translation apparatus. HmdII and HmdIII, but not the active dehydrogenase Hmd, bind with micromolar binding affinities to a number of tRNAs and form ternary complexes with tRNA(Pro) and prolyl-tRNA synthetase (ProRS). Fluorescence spectroscopy experiments also suggest that binding of HmdII and ProRS involves distinct binding determinants on the tRNA. These biochemical data suggest the possibility of a regulatory link between energy production and protein translation pathways that may allow a rapid cellular response to altered environmental conditions.

ISBN: 9781267648686Subjects--Topical Terms:

518028
Biochemistry.

A biochemical linkage between methanogenesis and protein synthesis in hydrogenotrophic archaea.
LDR:01869nmm a2200301 4500 001 2121065
005 20170724102943.5
008 180830s2012 ||||||||||||||||| ||eng d
020 $a 9781267648686
035 $a (MiAaPQ)AAI3540206
035 $a AAI3540206
040 $a MiAaPQ $c MiAaPQ
100 1 $a Oza, Javin Pradip. $3 3283058
245 1 2 $a A biochemical linkage between methanogenesis and protein synthesis in hydrogenotrophic archaea.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2012
300 $a 214 p.
500 $a Source: Dissertation Abstracts International, Volume: 74-02(E), Section: B.
500 $a Adviser: John Perona.
502 $a Thesis (Ph.D.)--University of California, Santa Barbara, 2012.
520 $a Hydrogenotrophic methanogens possessing the hydrogen-dependent dehydrogenase Hmd also encode paralogs of this protein whose function is poorly understood. Here we present biochemical evidence that the two inactive Hmd paralogs of Methanocaldococcus jannaschii, HmdII and HmdIII, form binary and ternary complexes with several components of the protein translation apparatus. HmdII and HmdIII, but not the active dehydrogenase Hmd, bind with micromolar binding affinities to a number of tRNAs and form ternary complexes with tRNA(Pro) and prolyl-tRNA synthetase (ProRS). Fluorescence spectroscopy experiments also suggest that binding of HmdII and ProRS involves distinct binding determinants on the tRNA. These biochemical data suggest the possibility of a regulatory link between energy production and protein translation pathways that may allow a rapid cellular response to altered environmental conditions.
590 $a School code: 0035.
650 4 $a Biochemistry. $3 518028
650 4 $a Molecular biology. $3 517296
650 4 $a Biophysics. $3 518360
690 $a 0487
690 $a 0307
690 $a 0786
710 2 $a University of California, Santa Barbara. $b Biomolecular Science and Engineering. $3 2096303
773 0 $t Dissertation Abstracts International $g 74-02B(E).
790 $a 0035
791 $a Ph.D.
792 $a 2012
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3540206