東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Oocyte quality: Molecular constituen...

Cox, Lindsay.

Linked to FindBook

Google Book

Amazon

博客來

Oocyte quality: Molecular constituents altered in the oocyte due to various environmental factors.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Oocyte quality: Molecular constituents altered in the oocyte due to various environmental factors./
Author:	Cox, Lindsay.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2016,
Description:	280 p.
Notes:	Source: Dissertation Abstracts International, Volume: 78-04(E), Section: B.
Contained By:	Dissertation Abstracts International78-04B(E).
Subject:	Animal sciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10168620
ISBN:	9781369228977

Oocyte quality: Molecular constituents altered in the oocyte due to various environmental factors.
Cox, Lindsay.

Oocyte quality: Molecular constituents altered in the oocyte due to various environmental factors. - Ann Arbor : ProQuest Dissertations & Theses, 2016 - 280 p.

Source: Dissertation Abstracts International, Volume: 78-04(E), Section: B.

Thesis (Ph.D.)--Utah State University, 2016.

An estimated 1.6 million American couples struggle with infertility. Some causes for poor fertility can be clearly defined but in many instances, subfertility is unexplained. Poor oocyte quality is now considered to be a main contributing factor for many causes of infertility. Good oocyte quality is crucial for many processes including embryo development and maintaining pregnancy. There is a possibility that any alterations to the oocyte can have long lasting effects on embryo development and the health of the offspring. The oocyte is very sensitive to any perturbations to its surrounding environment. Transcripts for apoptosis inhibitors and epigenetic modifiers were found to be significantly more abundant in in vivo-matured oocytes compared to oocytes that were matured in vitro. RNA degradation and chromatin remodeling pathways may also be perturbed in in vitro- matured oocytes. While examining the effects of maternal age on the oocyte, there are age-related differences in gene expression in equine cumulus-oocyte complexes. Differences in gene expression may lead to a decrease in oocyte developmental competence. Age related alterations to gene expression in the equine cumulus-oocyte complexes might be caused by increased rates of oxidative stress and subsequent DNA damage. These alterations could directly impact many processes within the oocyte. Higher incidences of apoptosis may be possible in the cumulus cells from aged mares, which would directly impact the developmental competence of the oocyte. Lastly, oocyte quality may be impacted by western dietary consumption patterns, which could lead to many genes being differentially expressed in oocytes. Alterations to the abundance of these genes have been shown to lead to effects that are commonly seen with metabolic syndrome, such as glucose intolerance, insulin resistance, obesity and diabetes. The results of this work will ultimately provide insight into the effects environmental influences have on the oocyte at the molecular level.

ISBN: 9781369228977Subjects--Topical Terms:

3174829
Animal sciences.

Oocyte quality: Molecular constituents altered in the oocyte due to various environmental factors.
LDR:02944nmm a2200289 4500 001 2120980
005 20170724102934.5
008 180830s2016 ||||||||||||||||| ||eng d
020 $a 9781369228977
035 $a (MiAaPQ)AAI10168620
035 $a AAI10168620
040 $a MiAaPQ $c MiAaPQ
100 1 $a Cox, Lindsay. $3 3282959
245 1 0 $a Oocyte quality: Molecular constituents altered in the oocyte due to various environmental factors.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2016
300 $a 280 p.
500 $a Source: Dissertation Abstracts International, Volume: 78-04(E), Section: B.
500 $a Adviser: Clay Isom.
502 $a Thesis (Ph.D.)--Utah State University, 2016.
520 $a An estimated 1.6 million American couples struggle with infertility. Some causes for poor fertility can be clearly defined but in many instances, subfertility is unexplained. Poor oocyte quality is now considered to be a main contributing factor for many causes of infertility. Good oocyte quality is crucial for many processes including embryo development and maintaining pregnancy. There is a possibility that any alterations to the oocyte can have long lasting effects on embryo development and the health of the offspring. The oocyte is very sensitive to any perturbations to its surrounding environment. Transcripts for apoptosis inhibitors and epigenetic modifiers were found to be significantly more abundant in in vivo-matured oocytes compared to oocytes that were matured in vitro. RNA degradation and chromatin remodeling pathways may also be perturbed in in vitro- matured oocytes. While examining the effects of maternal age on the oocyte, there are age-related differences in gene expression in equine cumulus-oocyte complexes. Differences in gene expression may lead to a decrease in oocyte developmental competence. Age related alterations to gene expression in the equine cumulus-oocyte complexes might be caused by increased rates of oxidative stress and subsequent DNA damage. These alterations could directly impact many processes within the oocyte. Higher incidences of apoptosis may be possible in the cumulus cells from aged mares, which would directly impact the developmental competence of the oocyte. Lastly, oocyte quality may be impacted by western dietary consumption patterns, which could lead to many genes being differentially expressed in oocytes. Alterations to the abundance of these genes have been shown to lead to effects that are commonly seen with metabolic syndrome, such as glucose intolerance, insulin resistance, obesity and diabetes. The results of this work will ultimately provide insight into the effects environmental influences have on the oocyte at the molecular level.
590 $a School code: 0241.
650 4 $a Animal sciences. $3 3174829
650 4 $a Developmental biology. $3 592588
690 $a 0475
690 $a 0758
710 2 $a Utah State University. $b Animal, Dairy and Veterinary Sciences. $3 3194303
773 0 $t Dissertation Abstracts International $g 78-04B(E).
790 $a 0241
791 $a Ph.D.
792 $a 2016
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10168620