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Detection and drug delivery from sup...

Falde, Eric John.

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Detection and drug delivery from superhydrophobic materials.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Detection and drug delivery from superhydrophobic materials./
Author:	Falde, Eric John.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2016,
Description:	140 p.
Notes:	Source: Dissertation Abstracts International, Volume: 77-07(E), Section: B.
Contained By:	Dissertation Abstracts International77-07B(E).
Subject:	Biomedical engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10016993
ISBN:	9781339499369

Detection and drug delivery from superhydrophobic materials.
Falde, Eric John.

Detection and drug delivery from superhydrophobic materials. - Ann Arbor : ProQuest Dissertations & Theses, 2016 - 140 p.

Source: Dissertation Abstracts International, Volume: 77-07(E), Section: B.

Thesis (Ph.D.)--Boston University, 2016.

The wetting of a rough material is controlled by surface chemistry and morphology, the liquid phase, solutes, and surfactants that affect the surface tension with the gas phase, and environmental conditions such as temperature and pressure. Materials with high (>150°) apparent contact angles are known as superhydrophobic and are very resistant to wetting. However, in complex biological mixtures eventually protein adsorbs, fouling the surface and facilitating wetting on time scales from seconds to months. The work here uses the partially-wetted (Cassie-Baxter) to fully-wetted (Wenzel) state transition to control drug delivery and to perform surfactant detection via surface tension using hydrophobic and superhydrophobic materials. First there is an overview of the physics of the non-wetting state and the transition to wetting. Then there is a review of how wetting can be controlled by outside stimuli and applications of these materials. Next there is work presented on controlling drug release using superhydrophobic materials with controlled wetting rates, with both in vitro and in vivo results. Then there is work on developing a sensor based on this wetting state transition and its applications toward detecting solute levels in biological fluids for point-of-care diagnosis. Finally, there is work presented on using these sensors for detecting the alcohol content in wine and spirits.

ISBN: 9781339499369Subjects--Topical Terms:

535387
Biomedical engineering.

Detection and drug delivery from superhydrophobic materials.
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035 $a (MiAaPQ)AAI10016993
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100 1 $a Falde, Eric John. $3 3282316
245 1 0 $a Detection and drug delivery from superhydrophobic materials.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2016
300 $a 140 p.
500 $a Source: Dissertation Abstracts International, Volume: 77-07(E), Section: B.
500 $a Adviser: Mark W. Grinstaff.
502 $a Thesis (Ph.D.)--Boston University, 2016.
520 $a The wetting of a rough material is controlled by surface chemistry and morphology, the liquid phase, solutes, and surfactants that affect the surface tension with the gas phase, and environmental conditions such as temperature and pressure. Materials with high (>150°) apparent contact angles are known as superhydrophobic and are very resistant to wetting. However, in complex biological mixtures eventually protein adsorbs, fouling the surface and facilitating wetting on time scales from seconds to months. The work here uses the partially-wetted (Cassie-Baxter) to fully-wetted (Wenzel) state transition to control drug delivery and to perform surfactant detection via surface tension using hydrophobic and superhydrophobic materials. First there is an overview of the physics of the non-wetting state and the transition to wetting. Then there is a review of how wetting can be controlled by outside stimuli and applications of these materials. Next there is work presented on controlling drug release using superhydrophobic materials with controlled wetting rates, with both in vitro and in vivo results. Then there is work on developing a sensor based on this wetting state transition and its applications toward detecting solute levels in biological fluids for point-of-care diagnosis. Finally, there is work presented on using these sensors for detecting the alcohol content in wine and spirits.
590 $a School code: 0017.
650 4 $a Biomedical engineering. $3 535387
650 4 $a Materials science. $3 543314
650 4 $a Pharmaceutical sciences. $3 3173021
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710 2 $a Boston University. $b Biomedical Engineering. $3 2095119
773 0 $t Dissertation Abstracts International $g 77-07B(E).
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793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10016993