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At the intersection of X-ray diffrac...

Newman, Justin A.

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At the intersection of X-ray diffraction and nonlinear optics.

Record Type:	Electronic resources : Monograph/item
Title/Author:	At the intersection of X-ray diffraction and nonlinear optics./
Author:	Newman, Justin A.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2016,
Description:	186 p.
Notes:	Source: Dissertation Abstracts International, Volume: 78-03(E), Section: B.
Contained By:	Dissertation Abstracts International78-03B(E).
Subject:	Analytical chemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10150118
ISBN:	9781369051599

At the intersection of X-ray diffraction and nonlinear optics.
Newman, Justin A.

At the intersection of X-ray diffraction and nonlinear optics. - Ann Arbor : ProQuest Dissertations & Theses, 2016 - 186 p.

Source: Dissertation Abstracts International, Volume: 78-03(E), Section: B.

Thesis (Ph.D.)--Purdue University, 2016.

The high brilliance of synchrotron facilities have led synchrotron X-ray diffraction to become an indispensable tool for crystallographers to determine both high resolution structures of proteins, as well as, to detect trace crystallinity of active pharmaceutical ingredients (APIs) within amorphous mixtures. However, as demand increases for time on synchrotron beamlines around the world, so to has arisen a need for high throughput, crystal specific methods for finding and locating the crystals within the synchrotron beam for structural analysis. Nonlinear optical (NLO) methods, such as second harmonic generation (SHG) and two-photon ultraviolet fluorescence (TPE-UVF) have emerged as rapid and reliable methods for finding protein crystals and APIs. Recently a multimodal NLO microscope was designed and installed at a synchrotron facility and is capable of detecting protein crystals and locating them in the center of the synchrotron beam for further structural analysis. This microscope was also used to monitor the damaging effects of synchrotron beam on the sample by SHG imaging. The limit of detection for powder X-ray diffraction (PXRD) of trace API crystallites within an amorphous powder was extended into the ppm range using the integrated NLO microscope for SHG guided PXRD.

ISBN: 9781369051599Subjects--Topical Terms:

3168300
Analytical chemistry.

At the intersection of X-ray diffraction and nonlinear optics.
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035 $a (MiAaPQ)AAI10150118
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100 1 $a Newman, Justin A. $3 3281834
245 1 0 $a At the intersection of X-ray diffraction and nonlinear optics.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2016
300 $a 186 p.
500 $a Source: Dissertation Abstracts International, Volume: 78-03(E), Section: B.
500 $a Adviser: Garth Simpson.
502 $a Thesis (Ph.D.)--Purdue University, 2016.
520 $a The high brilliance of synchrotron facilities have led synchrotron X-ray diffraction to become an indispensable tool for crystallographers to determine both high resolution structures of proteins, as well as, to detect trace crystallinity of active pharmaceutical ingredients (APIs) within amorphous mixtures. However, as demand increases for time on synchrotron beamlines around the world, so to has arisen a need for high throughput, crystal specific methods for finding and locating the crystals within the synchrotron beam for structural analysis. Nonlinear optical (NLO) methods, such as second harmonic generation (SHG) and two-photon ultraviolet fluorescence (TPE-UVF) have emerged as rapid and reliable methods for finding protein crystals and APIs. Recently a multimodal NLO microscope was designed and installed at a synchrotron facility and is capable of detecting protein crystals and locating them in the center of the synchrotron beam for further structural analysis. This microscope was also used to monitor the damaging effects of synchrotron beam on the sample by SHG imaging. The limit of detection for powder X-ray diffraction (PXRD) of trace API crystallites within an amorphous powder was extended into the ppm range using the integrated NLO microscope for SHG guided PXRD.
590 $a School code: 0183.
650 4 $a Analytical chemistry. $3 3168300
690 $a 0486
710 2 $a Purdue University. $b Chemistry. $3 1019176
773 0 $t Dissertation Abstracts International $g 78-03B(E).
790 $a 0183
791 $a Ph.D.
792 $a 2016
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10150118