東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Computational Investigations on Enzy...

Simard, Daniel.

Linked to FindBook

Google Book

Amazon

博客來

Computational Investigations on Enzymatic Catalysis and Inhibition.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Computational Investigations on Enzymatic Catalysis and Inhibition./
Author:	Simard, Daniel.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2015,
Description:	131 p.
Notes:	Source: Masters Abstracts International, Volume: 55-02.
Contained By:	Masters Abstracts International55-02(E).
Subject:	Physical chemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1602959
ISBN:	9781339191324

Computational Investigations on Enzymatic Catalysis and Inhibition.
Simard, Daniel.

Computational Investigations on Enzymatic Catalysis and Inhibition. - Ann Arbor : ProQuest Dissertations & Theses, 2015 - 131 p.

Source: Masters Abstracts International, Volume: 55-02.

Thesis (M.Sc.)--University of Windsor (Canada), 2015.

Enzymes are the bimolecular "workhorses" of the cell due to their range of functions and their requirement for cellular success. The atomistic details of how they function can provide key insights into the fundamentals of catalysis and in turn, provide a blueprint for biotechnological advances. A wide range of contemporary computational techniques has been applied with the aim to characterize recently discovered intermediates or to provide insights into enzymatic mechanisms and inhibition. More specifically, an assessment of methods was conducted to evaluate the presence of the growing number 3-- and 4--coordinated sulfur intermediates in proteins/enzymes. Furthermore, two mechanisms have been investigated, the mu-OH mechanism of the hydrolysis of dimethylphosphate in Glycerophosphodiesterase (GpdQ) using five different homonuclear metal combinations Zn(II)/Zn(II), Co(II)/Co(II), Mn(II)/Mn(II), Cd(II)/Cd(II) and Ca(II)/Ca(II) as well as a preliminary study into the effectivness of boron as an inhibitor in the serine protease reaction of class A TEM-1 beta-lactamases.

ISBN: 9781339191324Subjects--Topical Terms:

1981412
Physical chemistry.

Computational Investigations on Enzymatic Catalysis and Inhibition.
LDR:01962nmm a2200289 4500 001 2119295
005 20170619080607.5
008 180830s2015 ||||||||||||||||| ||eng d
020 $a 9781339191324
035 $a (MiAaPQ)AAI1602959
035 $a AAI1602959
040 $a MiAaPQ $c MiAaPQ
100 1 $a Simard, Daniel. $3 3281165
245 1 0 $a Computational Investigations on Enzymatic Catalysis and Inhibition.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2015
300 $a 131 p.
500 $a Source: Masters Abstracts International, Volume: 55-02.
500 $a Adviser: James W. Gauld.
502 $a Thesis (M.Sc.)--University of Windsor (Canada), 2015.
520 $a Enzymes are the bimolecular "workhorses" of the cell due to their range of functions and their requirement for cellular success. The atomistic details of how they function can provide key insights into the fundamentals of catalysis and in turn, provide a blueprint for biotechnological advances. A wide range of contemporary computational techniques has been applied with the aim to characterize recently discovered intermediates or to provide insights into enzymatic mechanisms and inhibition. More specifically, an assessment of methods was conducted to evaluate the presence of the growing number 3-- and 4--coordinated sulfur intermediates in proteins/enzymes. Furthermore, two mechanisms have been investigated, the mu-OH mechanism of the hydrolysis of dimethylphosphate in Glycerophosphodiesterase (GpdQ) using five different homonuclear metal combinations Zn(II)/Zn(II), Co(II)/Co(II), Mn(II)/Mn(II), Cd(II)/Cd(II) and Ca(II)/Ca(II) as well as a preliminary study into the effectivness of boron as an inhibitor in the serine protease reaction of class A TEM-1 beta-lactamases.
590 $a School code: 0115.
650 4 $a Physical chemistry. $3 1981412
650 4 $a Condensed matter physics. $3 3173567
690 $a 0494
690 $a 0611
710 2 $a University of Windsor (Canada). $b Chemistry and Biochemistry. $3 3194115
773 0 $t Masters Abstracts International $g 55-02(E).
790 $a 0115
791 $a M.Sc.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1602959