語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Palladium-catalyzed difunctionalizat...
~
McCammant, Matthew Scott.
FindBook
Google Book
Amazon
博客來
Palladium-catalyzed difunctionalization reactions of 1,3-dienes and terminal alkenes via pi-allyl stabilized intermediates.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Palladium-catalyzed difunctionalization reactions of 1,3-dienes and terminal alkenes via pi-allyl stabilized intermediates./
作者:
McCammant, Matthew Scott.
出版者:
Ann Arbor : ProQuest Dissertations & Theses, : 2016,
面頁冊數:
203 p.
附註:
Source: Dissertation Abstracts International, Volume: 77-10(E), Section: B.
Contained By:
Dissertation Abstracts International77-10B(E).
標題:
Analytical chemistry. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10118943
ISBN:
9781339802602
Palladium-catalyzed difunctionalization reactions of 1,3-dienes and terminal alkenes via pi-allyl stabilized intermediates.
McCammant, Matthew Scott.
Palladium-catalyzed difunctionalization reactions of 1,3-dienes and terminal alkenes via pi-allyl stabilized intermediates.
- Ann Arbor : ProQuest Dissertations & Theses, 2016 - 203 p.
Source: Dissertation Abstracts International, Volume: 77-10(E), Section: B.
Thesis (Ph.D.)--The University of Utah, 2016.
Palladium-catalyzed alkene difunctionalization reactions represent a powerful methodology for the construction of diverse carbon--carbon and carbon--heteroatom bonds. The success of these transformations requires the effective stabilization of alkyl--Pd intermediates generated following migratory insertion of an alkene. Stabilization of Pd-intermediates helps to prevent side reactions, thus enabling the formation of desired difunctionalization products in high selectivity. Chapter 1 examines distinctive methods used for the interception of alkyl--Pd intermediates and the strategies associated with minimizing byproduct formation.
ISBN: 9781339802602Subjects--Topical Terms:
3168300
Analytical chemistry.
Palladium-catalyzed difunctionalization reactions of 1,3-dienes and terminal alkenes via pi-allyl stabilized intermediates.
LDR
:03725nmm a2200337 4500
001
2119182
005
20170619080558.5
008
180830s2016 ||||||||||||||||| ||eng d
020
$a
9781339802602
035
$a
(MiAaPQ)AAI10118943
035
$a
AAI10118943
040
$a
MiAaPQ
$c
MiAaPQ
100
1
$a
McCammant, Matthew Scott.
$3
3281038
245
1 0
$a
Palladium-catalyzed difunctionalization reactions of 1,3-dienes and terminal alkenes via pi-allyl stabilized intermediates.
260
1
$a
Ann Arbor :
$b
ProQuest Dissertations & Theses,
$c
2016
300
$a
203 p.
500
$a
Source: Dissertation Abstracts International, Volume: 77-10(E), Section: B.
500
$a
Includes supplementary digital materials.
500
$a
Adviser: Matthew S. Sigman.
502
$a
Thesis (Ph.D.)--The University of Utah, 2016.
520
$a
Palladium-catalyzed alkene difunctionalization reactions represent a powerful methodology for the construction of diverse carbon--carbon and carbon--heteroatom bonds. The success of these transformations requires the effective stabilization of alkyl--Pd intermediates generated following migratory insertion of an alkene. Stabilization of Pd-intermediates helps to prevent side reactions, thus enabling the formation of desired difunctionalization products in high selectivity. Chapter 1 examines distinctive methods used for the interception of alkyl--Pd intermediates and the strategies associated with minimizing byproduct formation.
520
$a
The Sigman laboratory has been interested in alkene difunctionalization reactions that take advantage of the unique reactivity of pi-allyl/benzyl stabilized intermediates in order to generate significant molecular complexity from simple starting materials. Chapter 2 details the development of the Pd-catalyzed 1,4-difunctionalization of the commodity chemical 1,3-butadiene, which affords difficult to access skipped polyene products. This transformation regioselectively functionalizes the two terminal alkenes of 1,3-butadiene by means of a sigma → pi → sigma isomerization of cationic Pd-intermediates. The utility of the 1,4-difunctionalization of 1,3-butadiene is highlighted by the synthesis of a highly functionalized skipped triene-containing fragment of ripostatin A.
520
$a
Chapter 3 describes an advancement of the 1,4-difunctionalization reaction, namely using isoprene as the 1,3-diene substrate to generate skipped diene-containing terpenoid products. This method presents an added challenge resulting from the use of a 1,3-diene with two inequivalent alkenes that can contribute to complex isomeric product mixtures as the result of unselective alkene insertion. Through the use of pyridine-oxazoline-type ligands, good site selectivity of alkene insertion has been achieved. Mechanistic studies that combine design of experiments with systematic multiparameter ligand modulation ultimately suggest that the electronic asymmetry and steric properties of the ligand are critical to the observed enhancement in site selectivity of alkene insertion.
520
$a
The development of a 1,3-difunctionalization of terminal alkenes using 1,1-disubstituted vinyl triflates and boronic acids is discussed in Chapter 4. This transformation is realized using a novel difunctionalization strategy, and generates a new C(sp2)--C(sp2) double bond as well as a C(sp3)--C(sp2) bond. Dependent on the boronic acid coupling partner, the reaction affords skipped diene or allylic arene products stereo- and regioselectively.
590
$a
School code: 0240.
650
4
$a
Analytical chemistry.
$3
3168300
650
4
$a
Organic chemistry.
$3
523952
690
$a
0486
690
$a
0490
710
2
$a
The University of Utah.
$b
Chemistry.
$3
2103671
773
0
$t
Dissertation Abstracts International
$g
77-10B(E).
790
$a
0240
791
$a
Ph.D.
792
$a
2016
793
$a
English
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10118943
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9329800
電子資源
01.外借(書)_YB
電子書
EB
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入