東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Participation of retinal glucagonerg...

Nava, Diane Rachel.

Linked to FindBook

Google Book

Amazon

博客來

Participation of retinal glucagonergic amacrine cells in the regulation of eye growth and refractive error: Evidence from neurotoxins and in vivo immunolesioning.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Participation of retinal glucagonergic amacrine cells in the regulation of eye growth and refractive error: Evidence from neurotoxins and in vivo immunolesioning./
Author:	Nava, Diane Rachel.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2016,
Description:	160 p.
Notes:	Source: Dissertation Abstracts International, Volume: 78-01(E), Section: B.
Contained By:	Dissertation Abstracts International78-01B(E).
Subject:	Ophthalmology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10150995
ISBN:	9781369057591

Participation of retinal glucagonergic amacrine cells in the regulation of eye growth and refractive error: Evidence from neurotoxins and in vivo immunolesioning.
Nava, Diane Rachel.

Participation of retinal glucagonergic amacrine cells in the regulation of eye growth and refractive error: Evidence from neurotoxins and in vivo immunolesioning. - Ann Arbor : ProQuest Dissertations & Theses, 2016 - 160 p.

Source: Dissertation Abstracts International, Volume: 78-01(E), Section: B.

Thesis (Ph.D.)--University of California, Berkeley, 2016.

Growth is one of the fundamental characteristics of biological systems. The study of eye growth regulation presents an interesting window that allows for the investigation of the role of the visual environment on internal processes. We now know that there is an intricate circuitry within the eye, independent of higher brain processes, that controls the growth of the eye but more needs to be elucidated about these local regulatory circuits. An improved understanding of this circuitry is critical to developing new therapies for abnormalities in eye growth regulation such as myopia, which is impacting more and more individuals around the world each day and in its more severe from, is linked to potentially blinding ocular complications.

ISBN: 9781369057591Subjects--Topical Terms:

862704
Ophthalmology.

Participation of retinal glucagonergic amacrine cells in the regulation of eye growth and refractive error: Evidence from neurotoxins and in vivo immunolesioning.
LDR:03751nmm a2200337 4500 001 2118877
005 20170614101409.5
008 180830s2016 ||||||||||||||||| ||eng d
020 $a 9781369057591
035 $a (MiAaPQ)AAI10150995
035 $a AAI10150995
040 $a MiAaPQ $c MiAaPQ
100 1 $a Nava, Diane Rachel. $3 3280719
245 1 0 $a Participation of retinal glucagonergic amacrine cells in the regulation of eye growth and refractive error: Evidence from neurotoxins and in vivo immunolesioning.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2016
300 $a 160 p.
500 $a Source: Dissertation Abstracts International, Volume: 78-01(E), Section: B.
500 $a Adviser: Christine F. Wildsoet.
502 $a Thesis (Ph.D.)--University of California, Berkeley, 2016.
520 $a Growth is one of the fundamental characteristics of biological systems. The study of eye growth regulation presents an interesting window that allows for the investigation of the role of the visual environment on internal processes. We now know that there is an intricate circuitry within the eye, independent of higher brain processes, that controls the growth of the eye but more needs to be elucidated about these local regulatory circuits. An improved understanding of this circuitry is critical to developing new therapies for abnormalities in eye growth regulation such as myopia, which is impacting more and more individuals around the world each day and in its more severe from, is linked to potentially blinding ocular complications.
520 $a The role of retinal glucagon, a neuropeptide, in the regulation of eye growth and refractive error has attracted the interest of researchers over the past 15 years yet there remain many unresolved questions. The research described in this dissertation aimed to elucidate the respective roles in eye growth regulation of specific subpopulations of retinal glucagonergic amacrine cells, which have been the subject of much speculation as the source of inhibitory growth signals, i.e. stop signals, yet not thoroughly investigated.
520 $a The approach taken to investigate this problem is to ablate glucagonergic amacrine cells in vivo using different neurotoxins, and to examine how this affects the sign-dependent circuitry of eye growth regulation. In addition, with the advent of advancements in high resolution imaging and electrophysiology, we were able to characterize the effects of these neurotoxins on the region-specific and time-sensitive changes in the structure and function of the living retina.
520 $a That the inhibitory response induced by imposed myopic defocus remains intact, in spite of total ablation of glucagon cells (Chapter 5) or elimination of the peripheral glucagon cells (Chapter 3) and other unintended adverse retina effects, compared to findings from previous studies involving QUIS (Chapter 2) of this thesis, is a novel finding. These results point to the same conclusion that glucagon cells themselves are not responsible for the decoding of the sign of optical defocus, but appear to have a role in fine-tuning of compensatory growth responses. The results of our experiments also suggest that the choroid may serve as an intermediate relay, and the altered anterior chamber development raise the further possibility that retina-derived growth modulatory factors also regulate the anterior segment, perhaps reaching this more remote site by diffusion forward through the vitreous chamber or via the uvea.
590 $a School code: 0028.
650 4 $a Ophthalmology. $3 862704
650 4 $a Cellular biology. $3 3172791
650 4 $a Neurosciences. $3 588700
690 $a 0381
690 $a 0379
690 $a 0317
710 2 $a University of California, Berkeley. $b Vision Science. $3 3184364
773 0 $t Dissertation Abstracts International $g 78-01B(E).
790 $a 0028
791 $a Ph.D.
792 $a 2016
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10150995