東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Simulation Studies of Peptide Aggreg...

McGovern, Michael.

Linked to FindBook

Google Book

Amazon

博客來

Simulation Studies of Peptide Aggregation.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Simulation Studies of Peptide Aggregation./
Author:	McGovern, Michael.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2014,
Description:	80 p.
Notes:	Source: Dissertation Abstracts International, Volume: 76-11(E), Section: B.
Contained By:	Dissertation Abstracts International76-11B(E).
Subject:	Chemical engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3707870
ISBN:	9781321827279

Simulation Studies of Peptide Aggregation.
McGovern, Michael.

Simulation Studies of Peptide Aggregation. - Ann Arbor : ProQuest Dissertations & Theses, 2014 - 80 p.

Source: Dissertation Abstracts International, Volume: 76-11(E), Section: B.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2014.

An improved free energy calculation method for molecular simulations is presented which allows for accurate calculation of free energy as a function of multiple variables simultaneously without the systematic boundary errors that have plagued similar methods in the past. Molecular simulations are applied to study the aggregation behavior of beta-peptides, a class of synthetic protein-like molecules in order to learn about how molecular level properties lead to large scale self-assembly properties. Finally, simulations are used to examine the structure of human islet amyloid polypeptide, a peptide hormone whose aggregation is associated with diabetes, in a variety of experimental conditions in order to learn about how the solvent environment effects aggregation.

ISBN: 9781321827279Subjects--Topical Terms:

560457
Chemical engineering.

Simulation Studies of Peptide Aggregation.
LDR:01677nmm a2200301 4500 001 2117598
005 20170530090103.5
008 180830s2014 ||||||||||||||||| ||eng d
020 $a 9781321827279
035 $a (MiAaPQ)AAI3707870
035 $a AAI3707870
040 $a MiAaPQ $c MiAaPQ
100 1 $a McGovern, Michael. $3 3279378
245 1 0 $a Simulation Studies of Peptide Aggregation.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2014
300 $a 80 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-11(E), Section: B.
500 $a Adviser: Juan de Pablo.
502 $a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2014.
520 $a An improved free energy calculation method for molecular simulations is presented which allows for accurate calculation of free energy as a function of multiple variables simultaneously without the systematic boundary errors that have plagued similar methods in the past. Molecular simulations are applied to study the aggregation behavior of beta-peptides, a class of synthetic protein-like molecules in order to learn about how molecular level properties lead to large scale self-assembly properties. Finally, simulations are used to examine the structure of human islet amyloid polypeptide, a peptide hormone whose aggregation is associated with diabetes, in a variety of experimental conditions in order to learn about how the solvent environment effects aggregation.
590 $a School code: 0262.
650 4 $a Chemical engineering. $3 560457
650 4 $a Chemistry. $3 516420
650 4 $a Molecular chemistry. $3 1071612
690 $a 0542
690 $a 0485
690 $a 0431
710 2 $a The University of Wisconsin - Madison. $b Chemical Engineering. $3 2094015
773 0 $t Dissertation Abstracts International $g 76-11B(E).
790 $a 0262
791 $a Ph.D.
792 $a 2014
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3707870