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Insulin resistance, depression, and ...

Platt, Adrienne Milligan.

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Insulin resistance, depression, and the progression to type-2 diabetes in youth.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Insulin resistance, depression, and the progression to type-2 diabetes in youth./
Author:	Platt, Adrienne Milligan.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2014,
Description:	96 p.
Notes:	Source: Dissertation Abstracts International, Volume: 75-09(E), Section: B.
Contained By:	Dissertation Abstracts International75-09B(E).
Subject:	Nursing. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3622878
ISBN:	9781303949524

Insulin resistance, depression, and the progression to type-2 diabetes in youth.
Platt, Adrienne Milligan.

Insulin resistance, depression, and the progression to type-2 diabetes in youth. - Ann Arbor : ProQuest Dissertations & Theses, 2014 - 96 p.

Source: Dissertation Abstracts International, Volume: 75-09(E), Section: B.

Thesis (Ph.D.)--University of Kansas, 2014.

Childhood obesity has become epidemic in the United States. Coinciding with this rapid increase in obesity is the development of type-2 diabetes in youth. Little is known about the progression of insulin resistance to type-2 diabetes or association of depressive symptoms and impaired glucose metabolism in at-risk obese youth.

ISBN: 9781303949524Subjects--Topical Terms:

528444
Nursing.

Insulin resistance, depression, and the progression to type-2 diabetes in youth.
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100 1 $a Platt, Adrienne Milligan. $3 3279331
245 1 0 $a Insulin resistance, depression, and the progression to type-2 diabetes in youth.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2014
300 $a 96 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-09(E), Section: B.
500 $a Includes supplementary digital materials.
500 $a Advisers: Kelly Bosak; Carol Smith.
502 $a Thesis (Ph.D.)--University of Kansas, 2014.
520 $a Childhood obesity has become epidemic in the United States. Coinciding with this rapid increase in obesity is the development of type-2 diabetes in youth. Little is known about the progression of insulin resistance to type-2 diabetes or association of depressive symptoms and impaired glucose metabolism in at-risk obese youth.
520 $a A retrospective chart review and a secondary data analysis was done using a descriptive correlational design exploring the incidence of insulin resistance, hyperinsulinemia, impaired fasting glucose, impaired glucose tolerance, and progression to type-2 diabetes in a cohort of 78 high-risk obese youth age 11 to 17 years presenting to a pediatric endocrinology clinic from 2007 to 2009. Association between self-reported depressive symptom scores using the Center for Epidemiological Studies Depression Scale for Children (CES-DC) and measures above were also explored.
520 $a Of the 78 participants enrolled in the original study, 44 (56.4%) underwent oral glucose tolerance testing, and 4 (9.1%) were diagnosed with impaired glucose tolerance. None had a confirmed diagnosis of type-2 diabetes over the 6 year study period. Two hour oral glucose tolerance results significantly correlated with the initial HbA1c (r=.470, p=.007), the sum of insulin levels (r=.518, p=.001), and HOMA-IR (r=.429, p=.007). The insulin total correlated with HOMA-IR (r=.553, p=.001). The incidence of self-reported depressive symptoms was high in 35 (49 %) participants (n=71). None of the measures of impaired glucose metabolism correlated with depression scores.
520 $a These results indicate that even with a small sample of obese youth, 78 % met criteria for insulin resistance. The HbA1c correlated with 2-hour glucose tolerance test results. Glucose tolerance testing is used clinically for confirmatory diagnosis of impaired glucose tolerance and type-2 diabetes which support the use of HbA1c for screening youth. Despite lack of association between depressive symptoms and impaired glucose metabolism, 49% reported symptoms of depression with 11% moderate or severe. It would be prudent to screen all obese youth for depressive symptoms as this may impact their ability to implement lifestyle changes. Future research is needed with a larger prospective sample of high-risk obese youth to identify those more likely to develop type-2 diabetes and benefit from lifestyle interventions.
590 $a School code: 0099.
650 4 $a Nursing. $3 528444
650 4 $a Endocrinology. $3 610914
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710 2 $a University of Kansas. $b Nursing. $3 1679826
773 0 $t Dissertation Abstracts International $g 75-09B(E).
790 $a 0099
791 $a Ph.D.
792 $a 2014
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3622878