東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

The role of IRF3 in immune responses...

Moore, Tyler C.

FindBook

Google Book

Amazon

博客來

The role of IRF3 in immune responses controlling virus infection and tumor growth.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The role of IRF3 in immune responses controlling virus infection and tumor growth./
作者:	Moore, Tyler C.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2014,
面頁冊數:	241 p.
附註:	Source: Dissertation Abstracts International, Volume: 75-08(E), Section: B.
Contained By:	Dissertation Abstracts International75-08B(E).
標題:	Immunology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3617430
ISBN:	9781303848469

The role of IRF3 in immune responses controlling virus infection and tumor growth.
Moore, Tyler C.

The role of IRF3 in immune responses controlling virus infection and tumor growth. - Ann Arbor : ProQuest Dissertations & Theses, 2014 - 241 p.

Source: Dissertation Abstracts International, Volume: 75-08(E), Section: B.

Thesis (Ph.D.)--The University of Nebraska - Lincoln, 2014.

This item is not available from ProQuest Dissertations & Theses.

Humans are frequently exposed to potentially chronic virus infections throughout their lifetime. In some cases these virus infections are cleared through innate and adaptive immune responses, while in other cases they persist and can lead to disease. Theiler's Murine Encephalomyelitis Virus (TMEV) is a potentially persistent virus that causes acute encephalitis in the central nervous system of C57B6 (B6) mice that is cleared by both innate and adaptive immune responses. As a consequence of this immune mediate clearance of TMEV B6 mice exhibit damaged hippocampal regions of the brain. In contrast, susceptible strains of mice fail to clear the virus, develop a persistent infection and chronic neurological disease. An understanding of immune-mediated mechanisms that prevent chronic infection and disease in B6 mice could aid in developing preventions and therapies for potentially persistent viruses in humans. In addition, it is possible that these immune-mediated interventions could also aid in the therapy of non-infectious diseases, such as cancer. The following chapters describe studies of the role of interferon regulatory factor 3 (IRF3) in immune responses against TMEV. In addition, these studies identify genetic differences in IRF3 between TMEV-susceptible and resistant mice that could confer differential function. The following studies also indicate that IRF3 deficiency impacts both innate and adaptive responses to TMEV and prevents clearance of TMEV from the CNS but protects from immune-mediated damage to the CNS. Furthermore, IRF3 deficiency accelerates the growth of malignant melanoma of mice. Altogether, these results indicate that IRF3 is an important factor for innate and adaptive immune responses against both viruses and cancer and that IRF3 could be an important target for future therapeutics in humans.

ISBN: 9781303848469Subjects--Topical Terms:

611031
Immunology.

The role of IRF3 in immune responses controlling virus infection and tumor growth.
LDR:02892nmm a2200313 4500 001 2117549
005 20170530090058.5
008 180830s2014 ||||||||||||||||| ||eng d
020 $a 9781303848469
035 $a (MiAaPQ)AAI3617430
035 $a AAI3617430
040 $a MiAaPQ $c MiAaPQ
100 1 $a Moore, Tyler C. $3 3279326
245 1 4 $a The role of IRF3 in immune responses controlling virus infection and tumor growth.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2014
300 $a 241 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-08(E), Section: B.
500 $a Advisers: Thomas M. Petro; Deborah M. Brown.
502 $a Thesis (Ph.D.)--The University of Nebraska - Lincoln, 2014.
506 $a This item is not available from ProQuest Dissertations & Theses.
520 $a Humans are frequently exposed to potentially chronic virus infections throughout their lifetime. In some cases these virus infections are cleared through innate and adaptive immune responses, while in other cases they persist and can lead to disease. Theiler's Murine Encephalomyelitis Virus (TMEV) is a potentially persistent virus that causes acute encephalitis in the central nervous system of C57B6 (B6) mice that is cleared by both innate and adaptive immune responses. As a consequence of this immune mediate clearance of TMEV B6 mice exhibit damaged hippocampal regions of the brain. In contrast, susceptible strains of mice fail to clear the virus, develop a persistent infection and chronic neurological disease. An understanding of immune-mediated mechanisms that prevent chronic infection and disease in B6 mice could aid in developing preventions and therapies for potentially persistent viruses in humans. In addition, it is possible that these immune-mediated interventions could also aid in the therapy of non-infectious diseases, such as cancer. The following chapters describe studies of the role of interferon regulatory factor 3 (IRF3) in immune responses against TMEV. In addition, these studies identify genetic differences in IRF3 between TMEV-susceptible and resistant mice that could confer differential function. The following studies also indicate that IRF3 deficiency impacts both innate and adaptive responses to TMEV and prevents clearance of TMEV from the CNS but protects from immune-mediated damage to the CNS. Furthermore, IRF3 deficiency accelerates the growth of malignant melanoma of mice. Altogether, these results indicate that IRF3 is an important factor for innate and adaptive immune responses against both viruses and cancer and that IRF3 could be an important target for future therapeutics in humans.
590 $a School code: 0138.
650 4 $a Immunology. $3 611031
650 4 $a Virology. $3 642304
650 4 $a Biology. $3 522710
690 $a 0982
690 $a 0720
690 $a 0306
710 2 $a The University of Nebraska - Lincoln. $b Biological Sciences. $3 1682282
773 0 $t Dissertation Abstracts International $g 75-08B(E).
790 $a 0138
791 $a Ph.D.
792 $a 2014
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3617430