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Development of a canine coccidiosis ...

Mitchell, Sheila.

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Development of a canine coccidiosis model and the anticoccidial effects of a new chemotherapeutic agent.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Development of a canine coccidiosis model and the anticoccidial effects of a new chemotherapeutic agent./
Author:	Mitchell, Sheila.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2008,
Description:	193 p.
Notes:	Source: Dissertation Abstracts International, Volume: 73-10(E), Section: B.
Contained By:	Dissertation Abstracts International73-10B(E).
Subject:	Veterinary science. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=DP20025

Development of a canine coccidiosis model and the anticoccidial effects of a new chemotherapeutic agent.
Mitchell, Sheila.

Development of a canine coccidiosis model and the anticoccidial effects of a new chemotherapeutic agent. - Ann Arbor : ProQuest Dissertations & Theses, 2008 - 193 p.

Source: Dissertation Abstracts International, Volume: 73-10(E), Section: B.

Thesis (Ph.D.)--Virginia Polytechnic Institute and State University, 2008.

Coccidia are obligate intracellular parasites belonging to the phylum Apicomplexa. Many coccidia are of medical and veterinary importance such as Cystoisospora species and Toxoplasma gondii. The need to discover new anticoccidial therapies has increased due to development of resistance by the parasite or toxicity issues in the patient. The goals of this work were to develop a model for canine coccidiosis while proving that Cystoisospora canis is a true primary pathogen in dogs and to determine the efficacy of a new anticoccidial agent. A canine coccidiosis model would be useful in evaluating new anticoccidial treatments. Oral infections with 5 X 104 (n=2) and 1 X 105 (n=20) sporulated C. canis oocysts were attempted in 22 purpose bred beagle puppies. Clinical signs associated with disease were observed in all dogs. Bacterial and viral pathogens were ruled out by transmission electron microscopy (TEM) and bacterial growth assays. Development of C. canis in cell culture was also evaluated.Subjects--Topical Terms:

3172798
Veterinary science.

Development of a canine coccidiosis model and the anticoccidial effects of a new chemotherapeutic agent.
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035 $a (MiAaPQ)AAIDP20025
035 $a AAIDP20025
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100 1 $a Mitchell, Sheila. $3 3278722
245 1 0 $a Development of a canine coccidiosis model and the anticoccidial effects of a new chemotherapeutic agent.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2008
300 $a 193 p.
500 $a Source: Dissertation Abstracts International, Volume: 73-10(E), Section: B.
500 $a Adviser: David S. Lindsay.
502 $a Thesis (Ph.D.)--Virginia Polytechnic Institute and State University, 2008.
520 $a Coccidia are obligate intracellular parasites belonging to the phylum Apicomplexa. Many coccidia are of medical and veterinary importance such as Cystoisospora species and Toxoplasma gondii. The need to discover new anticoccidial therapies has increased due to development of resistance by the parasite or toxicity issues in the patient. The goals of this work were to develop a model for canine coccidiosis while proving that Cystoisospora canis is a true primary pathogen in dogs and to determine the efficacy of a new anticoccidial agent. A canine coccidiosis model would be useful in evaluating new anticoccidial treatments. Oral infections with 5 X 104 (n=2) and 1 X 105 (n=20) sporulated C. canis oocysts were attempted in 22 purpose bred beagle puppies. Clinical signs associated with disease were observed in all dogs. Bacterial and viral pathogens were ruled out by transmission electron microscopy (TEM) and bacterial growth assays. Development of C. canis in cell culture was also evaluated.
520 $a The efficacy of ponazuril, a new anticoccidial drug, was examined in T. gondii. In vitro studies were conducted to determine the activity of ponazuril on tachyzoites and how this agent affects development of apicomplexcan parasites. The tachyzoite production assay was conducted. Ponazuril at a dose of 1.0 mug/ml had a significant affect on tachyzoite reproduction. Comparisons were made on how ponazuril affects T. gondii and Neospora caninum. Inhibition of T. gondii tachyzoites occurred after the second round of replication and with N. caninum tachyzoites after 4 rounds of replication. Results of TEM revealed ponazuril affects replication of T. gondii and N. caninum differently.
520 $a The efficacy of ponazuril to prevent and treat acute and chronic toxoplasmosis was investigated. Mice treated prophylactically with ponazuril were completely protected from developing an acute T. gondii infection. Fatal toxoplasmosis was prevented in mice starting treatment 3 and 6 days post infection at a dose of 20 mg/kg. Immunohistochemistry was used to evaluate ponazuril's effect on chronic toxoplasmosis. Sections of brain were scored according to the number of tissue cysts present. Ponazuril also proved to be highly active against toxoplasmic encephalitis in an interferon-gamma knockout mouse model.
590 $a School code: 0247.
650 4 $a Veterinary science. $3 3172798
690 $a 0778
710 2 $a Virginia Polytechnic Institute and State University. $3 1017496
773 0 $t Dissertation Abstracts International $g 73-10B(E).
790 $a 0247
791 $a Ph.D.
792 $a 2008
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=DP20025