語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
The population level impact of HIV t...
~
Lesko, Catherine R.
FindBook
Google Book
Amazon
博客來
The population level impact of HIV treatment in the test-and-treat era.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
The population level impact of HIV treatment in the test-and-treat era./
作者:
Lesko, Catherine R.
面頁冊數:
110 p.
附註:
Source: Dissertation Abstracts International, Volume: 76-09(E), Section: B.
Contained By:
Dissertation Abstracts International76-09B(E).
標題:
Epidemiology. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3703843
ISBN:
9781321759044
The population level impact of HIV treatment in the test-and-treat era.
Lesko, Catherine R.
The population level impact of HIV treatment in the test-and-treat era.
- 110 p.
Source: Dissertation Abstracts International, Volume: 76-09(E), Section: B.
Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2015.
Antiretroviral therapy (ART) reduces mortality and prevents secondary transmission of HIV. Treatment guidelines now recommend initiating ART immediately following HIV diagnosis. The impact of this test-and-treat strategy on survival among HIV-infected persons in the United States (US) is unknown. First, published estimates of the effect of ART have been based on cohorts that are not representative of this target population. Second, evidence as to whether racial/ethnic/sex disparities in survival persist following ART initiation is mixed.
ISBN: 9781321759044Subjects--Topical Terms:
568544
Epidemiology.
The population level impact of HIV treatment in the test-and-treat era.
LDR
:03293nmm a2200325 4500
001
2115061
005
20161114124748.5
008
180830s2015 ||||||||||||||||| ||eng d
020
$a
9781321759044
035
$a
(MiAaPQ)AAI3703843
035
$a
AAI3703843
040
$a
MiAaPQ
$c
MiAaPQ
100
1
$a
Lesko, Catherine R.
$3
3276690
245
1 4
$a
The population level impact of HIV treatment in the test-and-treat era.
300
$a
110 p.
500
$a
Source: Dissertation Abstracts International, Volume: 76-09(E), Section: B.
500
$a
Adviser: Stephen R. Cole.
502
$a
Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2015.
520
$a
Antiretroviral therapy (ART) reduces mortality and prevents secondary transmission of HIV. Treatment guidelines now recommend initiating ART immediately following HIV diagnosis. The impact of this test-and-treat strategy on survival among HIV-infected persons in the United States (US) is unknown. First, published estimates of the effect of ART have been based on cohorts that are not representative of this target population. Second, evidence as to whether racial/ethnic/sex disparities in survival persist following ART initiation is mixed.
520
$a
In this dissertation, I estimated 5-year mortality risks for ART initiators versus non-initiators among 12,547 patients in the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) using the complement of weighted Kaplan-Meier survival functions. I subsequently standardized estimates to persons diagnosed with HIV in the US between 2009 and 2011, enumerated using national surveillance data from the Centers for Disease Control and Prevention. Furthermore, I calculated the 10-year all-cause mortality risk among 10,017 ART initiators, stratified by race/ethnicity and sex, from weighted Kaplan-Meier survival functions.
520
$a
The 5-year mortality among ART initiators in the CNICS was 10.6% (95% CI: 9.3%, 11.9%) compared to 28.3% (95% CI: 19.1%, 37.5%) among non-initiators. ART initiation lowered 5-year mortality by -19.1% (95% CI: -30.5%, -7.8%) among recently HIV-diagnosed persons in the US. This effect was similar to the effect of ART estimated in the CNICS (risk difference: -17.7%, 95% CI: -27.0%, -8.4%). The overall 10-year mortality risk among ART initiators was 20.2% (95% confidence interval (CI): 19.2%, 21.3%). Black men and women experienced standardized 10-year all-cause mortality risks that were 7.2% (95% CI: 4.3%, 10.1%) and 7.9% (95% CI: 3.9%, 12.0%) larger than white men. White women, Hispanic men, and Hispanic women all had lower 10-year mortality than white men.
520
$a
ART initiation substantially lowers mortality among persons in the CNICS and this benefit is expected to be similar among persons recently diagnosed with HIV in the US. However, survival following ART initiation differs by race/ethnicity. Effective interventions are needed to ensure that the goal of the National HIV/AIDS Strategy to overcome health disparities becomes a reality.
590
$a
School code: 0153.
650
4
$a
Epidemiology.
$3
568544
650
4
$a
Public health.
$3
534748
650
4
$a
Ethnic studies.
$2
bicssc
$3
1556779
690
$a
0766
690
$a
0573
690
$a
0631
710
2
$a
The University of North Carolina at Chapel Hill.
$b
Epidemiology.
$3
1269376
773
0
$t
Dissertation Abstracts International
$g
76-09B(E).
790
$a
0153
791
$a
Ph.D.
792
$a
2015
793
$a
English
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3703843
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9325682
電子資源
01.外借(書)_YB
電子書
EB
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入