語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Early intervention in a mouse model ...
~
Lerea, Jaclyn S.
FindBook
Google Book
Amazon
博客來
Early intervention in a mouse model of childhood obesity: effects on brown adipose tissue function.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Early intervention in a mouse model of childhood obesity: effects on brown adipose tissue function./
作者:
Lerea, Jaclyn S.
面頁冊數:
205 p.
附註:
Source: Dissertation Abstracts International, Volume: 77-10(E), Section: B.
Contained By:
Dissertation Abstracts International77-10B(E).
標題:
Nutrition. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10118961
ISBN:
9781339802787
Early intervention in a mouse model of childhood obesity: effects on brown adipose tissue function.
Lerea, Jaclyn S.
Early intervention in a mouse model of childhood obesity: effects on brown adipose tissue function.
- 205 p.
Source: Dissertation Abstracts International, Volume: 77-10(E), Section: B.
Thesis (Ph.D.)--Columbia University, 2016.
Due to the high childhood obesity rates within the United States, it is necessary to develop efficacious strategies to combat childhood obesity. To explore whether early intervention can produce lasting metabolic improvements, we used a mouse model of genetically-induced hypothalamic leptin resistance (LeprNkx2.1knockout, hereby known as KO) that exhibits early-onset hyperphagia and obesity. We found that KO mice exhibit reduced capacity of the brown adipose tissue (as seen by disorganized mitochondrial structure). Brown adipose tissue capacity can be restored by paired-feeding in the peri-weaning period, leading to persistent improvements in later adiposity even after restriction ends. These studies lead us to investigate the maturation process of brown adipose tissue in the peri-weaning period. We found that brown adipose tissue expansion between 2 to 3 weeks of age is accompanied by a reduced thermogenic capacity in control mice, as determined by protein levels of uncoupling protein 1 and disorganization of the mitochondrial cristae. Thermogenic function was restored by 5 weeks of age, as demonstrated by a peak of uncoupling protein 1, in control mice but not KO mice. Paired-feeding of KO mice in the peri-weaning period rescued this peak at 5 weeks of age. These studies elucidate a critical period when brown adipose tissue expansion is followed by activation. The magnitude of brown adipose tissue activation at this time might be predictive of future obesity and metabolic rate, highlighting a potential therapeutic time window in which to intervene in pediatric obesity.
ISBN: 9781339802787Subjects--Topical Terms:
517777
Nutrition.
Early intervention in a mouse model of childhood obesity: effects on brown adipose tissue function.
LDR
:02501nmm a2200277 4500
001
2114987
005
20161114124734.5
008
180830s2016 ||||||||||||||||| ||eng d
020
$a
9781339802787
035
$a
(MiAaPQ)AAI10118961
035
$a
AAI10118961
040
$a
MiAaPQ
$c
MiAaPQ
100
1
$a
Lerea, Jaclyn S.
$3
3276607
245
1 0
$a
Early intervention in a mouse model of childhood obesity: effects on brown adipose tissue function.
300
$a
205 p.
500
$a
Source: Dissertation Abstracts International, Volume: 77-10(E), Section: B.
500
$a
Adviser: Lori M. Zeltser.
502
$a
Thesis (Ph.D.)--Columbia University, 2016.
520
$a
Due to the high childhood obesity rates within the United States, it is necessary to develop efficacious strategies to combat childhood obesity. To explore whether early intervention can produce lasting metabolic improvements, we used a mouse model of genetically-induced hypothalamic leptin resistance (LeprNkx2.1knockout, hereby known as KO) that exhibits early-onset hyperphagia and obesity. We found that KO mice exhibit reduced capacity of the brown adipose tissue (as seen by disorganized mitochondrial structure). Brown adipose tissue capacity can be restored by paired-feeding in the peri-weaning period, leading to persistent improvements in later adiposity even after restriction ends. These studies lead us to investigate the maturation process of brown adipose tissue in the peri-weaning period. We found that brown adipose tissue expansion between 2 to 3 weeks of age is accompanied by a reduced thermogenic capacity in control mice, as determined by protein levels of uncoupling protein 1 and disorganization of the mitochondrial cristae. Thermogenic function was restored by 5 weeks of age, as demonstrated by a peak of uncoupling protein 1, in control mice but not KO mice. Paired-feeding of KO mice in the peri-weaning period rescued this peak at 5 weeks of age. These studies elucidate a critical period when brown adipose tissue expansion is followed by activation. The magnitude of brown adipose tissue activation at this time might be predictive of future obesity and metabolic rate, highlighting a potential therapeutic time window in which to intervene in pediatric obesity.
590
$a
School code: 0054.
650
4
$a
Nutrition.
$3
517777
650
4
$a
Morphology.
$3
591167
690
$a
0570
690
$a
0287
710
2
$a
Columbia University.
$b
Nutritional and Metabolic Biology.
$3
1684898
773
0
$t
Dissertation Abstracts International
$g
77-10B(E).
790
$a
0054
791
$a
Ph.D.
792
$a
2016
793
$a
English
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10118961
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9325608
電子資源
01.外借(書)_YB
電子書
EB
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入